Becker's Nevus Syndrome

Maria Elena Cucuzza, Sara Paternò, Daniele Attardo, Andrea D. Praticò, Stefano Catanzaro, Agata Polizzi, Carmelo Schepis, Francesco Lacarrubba, Giuseppe Micali, Anna Elisa Verzì, Concetta Pirrone, Elena Commodari, Antonio Zanghì, Stefania Salafia, Elena R. Praticò, Ignacio Pascual-Castroviejo, Martino Ruggieri

Research output: Contribution to journalReview article

Abstract

The simultaneous occurrence of a patch of light or dark brown hyperpigmentation with hypertrichosis (Becker's nevus) together with (usually ipsilateral) soft tissues hypoplasia (especially breast, in women) and underlying skeletal anomalies (i.e., vertebral hypoplasia, scoliosis, pectus carinatum or excavatum) represents the Becker's nevus syndrome (BNS) phenotype. It was first described (as a single cutaneous lesion) by Becker in 1949 and then associated with the surrounding musculoskeletal disorders. The syndrome has also been reported as pigmentary hairy epidermal nevus syndrome. Less than 100 cases have been reported in the literature, with a slightly higher incidence in females and only few familiar cases: paradominant postzygotic mutations and/or an androgen-dependent hyperactivation have been reported as the causes of the diseases. The extracutaneous lesions are congenital and nonprogressive, and the natural history of the Becker's nevus is the same as that of isolated nevi: in prepubertal boys, the pigmentation may be less intense and the hairiness may be absent or mild, as occurs in women, whereas in men, there is an increase of hairiness after puberty. The treatment is essentially cosmetic, and potential therapeutic options include electrolysis, waxing, makeup, or laser.

Original languageEnglish
Pages (from-to)352-361
Number of pages10
JournalJournal of Pediatric Neurology
Volume16
Issue number5
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Nevus
Hypertrichosis
Funnel Chest
Electrolysis
Hyperpigmentation
Pigmentation
Scoliosis
Puberty
Natural History
Cosmetics
Androgens
Breast
Lasers
Phenotype
Light
Skin
Mutation
Incidence
Therapeutics
Becker Nevus Syndrome

Keywords

  • Becker's nevus
  • hyperpigmentation
  • hypertrichosis
  • skeletal abnormalities
  • soft tissues hypoplasia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Cucuzza, M. E., Paternò, S., Attardo, D., Praticò, A. D., Catanzaro, S., Polizzi, A., ... Ruggieri, M. (2018). Becker's Nevus Syndrome. Journal of Pediatric Neurology, 16(5), 352-361. https://doi.org/10.1055/s-0038-1667168

Becker's Nevus Syndrome. / Cucuzza, Maria Elena; Paternò, Sara; Attardo, Daniele; Praticò, Andrea D.; Catanzaro, Stefano; Polizzi, Agata; Schepis, Carmelo; Lacarrubba, Francesco; Micali, Giuseppe; Verzì, Anna Elisa; Pirrone, Concetta; Commodari, Elena; Zanghì, Antonio; Salafia, Stefania; Praticò, Elena R.; Pascual-Castroviejo, Ignacio; Ruggieri, Martino.

In: Journal of Pediatric Neurology, Vol. 16, No. 5, 01.01.2018, p. 352-361.

Research output: Contribution to journalReview article

Cucuzza, ME, Paternò, S, Attardo, D, Praticò, AD, Catanzaro, S, Polizzi, A, Schepis, C, Lacarrubba, F, Micali, G, Verzì, AE, Pirrone, C, Commodari, E, Zanghì, A, Salafia, S, Praticò, ER, Pascual-Castroviejo, I & Ruggieri, M 2018, 'Becker's Nevus Syndrome', Journal of Pediatric Neurology, vol. 16, no. 5, pp. 352-361. https://doi.org/10.1055/s-0038-1667168
Cucuzza ME, Paternò S, Attardo D, Praticò AD, Catanzaro S, Polizzi A et al. Becker's Nevus Syndrome. Journal of Pediatric Neurology. 2018 Jan 1;16(5):352-361. https://doi.org/10.1055/s-0038-1667168
Cucuzza, Maria Elena ; Paternò, Sara ; Attardo, Daniele ; Praticò, Andrea D. ; Catanzaro, Stefano ; Polizzi, Agata ; Schepis, Carmelo ; Lacarrubba, Francesco ; Micali, Giuseppe ; Verzì, Anna Elisa ; Pirrone, Concetta ; Commodari, Elena ; Zanghì, Antonio ; Salafia, Stefania ; Praticò, Elena R. ; Pascual-Castroviejo, Ignacio ; Ruggieri, Martino. / Becker's Nevus Syndrome. In: Journal of Pediatric Neurology. 2018 ; Vol. 16, No. 5. pp. 352-361.
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