Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis

Andrey Maryandyshev, Emanuele Pontali, Simon Tiberi, Onno Akkerman, Shashank Ganatra, Tsetan Dorji Sadutshang, Jan-Willem Alffenaar, Rohit Amale, Jai Mullerpattan, Sonam Topgyal, Zarir Farokh Udwadia, Rosella Centis, Lia D'Ambrosio, Giovanni Sotgiu, Giovanni Battista Migliori

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Abstract

We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options.

Original languageEnglish
JournalEmerging Infectious Diseases
Volume23
Issue number10
DOIs
Publication statusPublished - Oct 2017

Keywords

  • Journal Article

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    Maryandyshev, A., Pontali, E., Tiberi, S., Akkerman, O., Ganatra, S., Sadutshang, T. D., Alffenaar, J-W., Amale, R., Mullerpattan, J., Topgyal, S., Udwadia, Z. F., Centis, R., D'Ambrosio, L., Sotgiu, G., & Migliori, G. B. (2017). Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis. Emerging Infectious Diseases, 23(10). https://doi.org/10.3201/eid2310.170834