Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis

Andrey Maryandyshev; Emanuele Pontali; Simon Tiberi; Onno Akkerman; Shashank Ganatra; Tsetan Dorji Sadutshang; Jan-Willem Alffenaar; Rohit Amale; Jai Mullerpattan; Sonam Topgyal; Zarir Farokh Udwadia; Rosella Centis; Lia D'Ambrosio; Giovanni Sotgiu; Giovanni Battista Migliori

doi:10.3201/eid2310.170834

Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis

Andrey Maryandyshev, Emanuele Pontali, Simon Tiberi, Onno Akkerman, Shashank Ganatra, Tsetan Dorji Sadutshang, Jan-Willem Alffenaar, Rohit Amale, Jai Mullerpattan, Sonam Topgyal, Zarir Farokh Udwadia, Rosella Centis, Lia D'Ambrosio, Giovanni Sotgiu, Giovanni Battista Migliori

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options.

Original language	English
Journal	Emerging Infectious Diseases
Volume	23
Issue number	10
DOIs	https://doi.org/10.3201/eid2310.170834
Publication status	Published - Oct 2017

Keywords

Journal Article

Access to Document

10.3201/eid2310.170834

Fingerprint Dive into the research topics of 'Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis'. Together they form a unique fingerprint.

Cite this

Maryandyshev, A., Pontali, E., Tiberi, S., Akkerman, O., Ganatra, S., Sadutshang, T. D., Alffenaar, J-W., Amale, R., Mullerpattan, J., Topgyal, S., Udwadia, Z. F., Centis, R., D'Ambrosio, L., Sotgiu, G., & Migliori, G. B. (2017). Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis. Emerging Infectious Diseases, 23(10). https://doi.org/10.3201/eid2310.170834

Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis. / Maryandyshev, Andrey; Pontali, Emanuele; Tiberi, Simon; Akkerman, Onno; Ganatra, Shashank; Sadutshang, Tsetan Dorji; Alffenaar, Jan-Willem; Amale, Rohit; Mullerpattan, Jai; Topgyal, Sonam; Udwadia, Zarir Farokh; Centis, Rosella; D'Ambrosio, Lia; Sotgiu, Giovanni; Migliori, Giovanni Battista.

In: Emerging Infectious Diseases, Vol. 23, No. 10, 10.2017.

Research output: Contribution to journal › Article › peer-review

Maryandyshev, A, Pontali, E, Tiberi, S, Akkerman, O, Ganatra, S, Sadutshang, TD, Alffenaar, J-W, Amale, R, Mullerpattan, J, Topgyal, S, Udwadia, ZF, Centis, R, D'Ambrosio, L, Sotgiu, G & Migliori, GB 2017, 'Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis', Emerging Infectious Diseases, vol. 23, no. 10. https://doi.org/10.3201/eid2310.170834

Maryandyshev, Andrey ; Pontali, Emanuele ; Tiberi, Simon ; Akkerman, Onno ; Ganatra, Shashank ; Sadutshang, Tsetan Dorji ; Alffenaar, Jan-Willem ; Amale, Rohit ; Mullerpattan, Jai ; Topgyal, Sonam ; Udwadia, Zarir Farokh ; Centis, Rosella ; D'Ambrosio, Lia ; Sotgiu, Giovanni ; Migliori, Giovanni Battista. / Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis. In: Emerging Infectious Diseases. 2017 ; Vol. 23, No. 10.

@article{f1df3b402d9547018d44dcaaf8f4892c,

title = "Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis",

abstract = "We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options.",

keywords = "Journal Article",

author = "Andrey Maryandyshev and Emanuele Pontali and Simon Tiberi and Onno Akkerman and Shashank Ganatra and Sadutshang, {Tsetan Dorji} and Jan-Willem Alffenaar and Rohit Amale and Jai Mullerpattan and Sonam Topgyal and Udwadia, {Zarir Farokh} and Rosella Centis and Lia D'Ambrosio and Giovanni Sotgiu and Migliori, {Giovanni Battista}",

year = "2017",

month = oct,

doi = "10.3201/eid2310.170834",

language = "English",

volume = "23",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "10",

}

TY - JOUR

T1 - Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis

AU - Maryandyshev, Andrey

AU - Pontali, Emanuele

AU - Tiberi, Simon

AU - Akkerman, Onno

AU - Ganatra, Shashank

AU - Sadutshang, Tsetan Dorji

AU - Alffenaar, Jan-Willem

AU - Amale, Rohit

AU - Mullerpattan, Jai

AU - Topgyal, Sonam

AU - Udwadia, Zarir Farokh

AU - Centis, Rosella

AU - D'Ambrosio, Lia

AU - Sotgiu, Giovanni

AU - Migliori, Giovanni Battista

PY - 2017/10

Y1 - 2017/10

N2 - We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options.

AB - We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options.

KW - Journal Article

U2 - 10.3201/eid2310.170834

DO - 10.3201/eid2310.170834

M3 - Article

C2 - 28758888

VL - 23

JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

SN - 1080-6040

IS - 10

ER -