Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis

Andrey Maryandyshev; Emanuele Pontali; Simon Tiberi; Onno Akkerman; Shashank Ganatra; Tsetan Dorji Sadutshang; Jan-Willem Alffenaar; Rohit Amale; Jai Mullerpattan; Sonam Topgyal; Zarir Farokh Udwadia; Rosella Centis; Lia D'Ambrosio; Giovanni Sotgiu; Giovanni Battista Migliori

doi:10.3201/eid2310.170834

Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis

Andrey Maryandyshev, Emanuele Pontali, Simon Tiberi, Onno Akkerman, Shashank Ganatra, Tsetan Dorji Sadutshang, Jan-Willem Alffenaar, Rohit Amale, Jai Mullerpattan, Sonam Topgyal, Zarir Farokh Udwadia, Rosella Centis, Lia D'Ambrosio, Giovanni Sotgiu, Giovanni Battista Migliori

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article

Abstract

We report the experiences of 5 patients taking bedaquiline with delamanid in combination: 1 patient was cured; 3 culture converted, with 2 continuing and 1 changing therapy; and 1 died from respiratory insufficiency. For 2 patients, QT-interval prolongation but no arrhythmias occurred. Use of this therapy is justified for patients with limited options.

Original language	English
Journal	Emerging Infectious Diseases
Volume	23
Issue number	10
DOIs	https://doi.org/10.3201/eid2310.170834
Publication status	Published - Oct 2017

Keywords

Journal Article

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Maryandyshev, A., Pontali, E., Tiberi, S., Akkerman, O., Ganatra, S., Sadutshang, T. D., Alffenaar, J-W., Amale, R., Mullerpattan, J., Topgyal, S., Udwadia, Z. F., Centis, R., D'Ambrosio, L., Sotgiu, G., & Migliori, G. B. (2017). Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis. Emerging Infectious Diseases, 23(10). https://doi.org/10.3201/eid2310.170834

Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis. / Maryandyshev, Andrey; Pontali, Emanuele; Tiberi, Simon; Akkerman, Onno; Ganatra, Shashank; Sadutshang, Tsetan Dorji; Alffenaar, Jan-Willem; Amale, Rohit; Mullerpattan, Jai; Topgyal, Sonam; Udwadia, Zarir Farokh; Centis, Rosella; D'Ambrosio, Lia; Sotgiu, Giovanni; Migliori, Giovanni Battista.

In: Emerging Infectious Diseases, Vol. 23, No. 10, 10.2017.

Research output: Contribution to journal › Article

Maryandyshev, A, Pontali, E, Tiberi, S, Akkerman, O, Ganatra, S, Sadutshang, TD, Alffenaar, J-W, Amale, R, Mullerpattan, J, Topgyal, S, Udwadia, ZF, Centis, R, D'Ambrosio, L, Sotgiu, G & Migliori, GB 2017, 'Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis', Emerging Infectious Diseases, vol. 23, no. 10. https://doi.org/10.3201/eid2310.170834

Maryandyshev, Andrey ; Pontali, Emanuele ; Tiberi, Simon ; Akkerman, Onno ; Ganatra, Shashank ; Sadutshang, Tsetan Dorji ; Alffenaar, Jan-Willem ; Amale, Rohit ; Mullerpattan, Jai ; Topgyal, Sonam ; Udwadia, Zarir Farokh ; Centis, Rosella ; D'Ambrosio, Lia ; Sotgiu, Giovanni ; Migliori, Giovanni Battista. / Bedaquiline and Delamanid Combination Treatment of 5 Patients with Pulmonary Extensively Drug-Resistant Tuberculosis. In: Emerging Infectious Diseases. 2017 ; Vol. 23, No. 10.

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