Behçet syndrome: from pathogenesis to novel therapies

Gianluigi Mazzoccoli, Angela Matarangolo, Rosa Rubino, Michele Inglese, Angelo De Cata

Research output: Contribution to journalArticlepeer-review


Behçet syndrome is a chronic disease hallmarked by inflammation of the blood vessels that is related to an autoimmune reaction caused by inherited susceptibility due to specific genes and environmental factors, probably components of infectious microorganisms, which turn on or get going the disease in genetically susceptible subjects. The more common clinical expression of the disease is represented by a triple-symptom complex of recurrent oral aphthous ulcers, genital ulcers, and uveitis, sometimes associated with inflammatory arthritis, phlebitis, iritis, as well as inflammation of the digestive tract, brain, and spinal cord. The treatment strategies used to manage the manifestations of Behçet syndrome have gradually progressed, and a number of new therapeutic resources have been implemented in recent years, allowing better control of pathogenic mechanisms, reducing symptoms and suffering, and ameliorating patient’s outcome.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalClinical and Experimental Medicine
Issue number1
Publication statusPublished - Feb 1 2016


  • Aphthae
  • Arthritis
  • Behçet
  • Immunosuppression
  • Uveitis
  • Vasculitis

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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