Behavior of frozen serum pools and lyophilized sera in an external quality-assessment scheme

C. A. Ferrero, A. Carobene, F. Ceriotti, A. Modenese, C. Arcelloni

Research output: Contribution to journalArticlepeer-review


To further improve analytical accuracy in clinical chemistry, proficiency testing needs amelioration in the quality of materials tested and in target value assignment. To obtain information on the actual state-of-the-art in the Lombardy region of Italy, and to examine the behavior of different types of control materials (fresh-frozen human sera and lyophilized materials), we developed the following experimental design. Two human serum pools and two lyophilized sera were distributed to 32 laboratories for determination of glucose, creatinine, cholesterol, sodium, potassium, and γ- glutamyltransferase (γ-GT). Each analyte was measured in triplicate on each of 3 days. Target values for the controls were obtained with Reference Methods. The results show a good intralaboratory precision for every component but some accuracy problems for glucose, creatinine, cholesterol, and γ-GT. Lyophilized materials showed some commutability problems for glucose, electrolytes, and γ-GT, mainly with dry chemistry technology.

Original languageEnglish
Pages (from-to)575-580
Number of pages6
JournalClinical Chemistry
Issue number4
Publication statusPublished - 1995


  • control materials
  • quality control
  • Reference Methods
  • variation, source of

ASJC Scopus subject areas

  • Clinical Biochemistry


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