Behavior of gangliosides on dialysis

R. Ghidoni, S. Sonnino, G. Tettamanti

Research output: Contribution to journalArticlepeer-review

Abstract

Mixed brain gangliosides or individual ganglioside GM1 were dissolved in one of the following solvents: (a) water, (b) 0.1 M aqueous KC1, or (c) methanol-aqueous 0.1 M KC1 at concentrations ranging from 10-8 to 10-3 M, and were submitted to dialysis against distilled water for up to 4 days. No significant loss of gangliosides on dialysis was observed when gangliosides were dissolved in water or 0.1 M aqueous KC1, but a loss occurred when the ganglioside solution contained methanol; the loss was greater at the lowest ganglioside concentration. However, losses ceased to occur after 1 day when methanol was removed from the dialysis sac.

Original languageEnglish
Pages (from-to)820-822
Number of pages3
JournalLipids
Volume13
Issue number11
DOIs
Publication statusPublished - Nov 1978

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Food Science

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