Behavior of non-classical soluble HLA class G antigens in human immunodeficiency virus 1-infected patients before and after HAART: Comparison with classical soluble HLA-A, -B, -C antigens and potential role in immune-reconstitution

Giuseppe Murdaca, Paola Contini, Maurizio Setti, Paola Cagnati, Francesca Lantieri, Francesco Indiveri, Francesco Puppo

Research output: Contribution to journalArticlepeer-review

Abstract

We have reported that serum level of soluble HLA-A, -B, -C (sHLA-A,-B,-C) antigens is elevated in HIV-infected subjects and decreases after antiretroviral therapy (HAART). In this study, we measured the levels of soluble HLA-G (sHLA-G) antigens in a cohort of HIV-infected patients before and during HAART. sHLA-G and sHLA-A, -B, -C levels were significantly elevated in HIV-infected subjects as compared with controls before antiretroviral treatment and significantly decreased after 36 months of HAART. sHLA-G levels were correlated with sHLA-A, -B, -C levels, the decrease of plasma HIV-RNA level, the increase of CD4+ T-lymphocyte number and the decrease of CD8+ T-lymphocyte number. These results suggest that the measurement of sHLA-G and sHLA-A, -B, -C antigen serum levels might represent a useful surrogate marker to monitor virological response and immune reconstitution in HIV-positive subjects undergoing HAART treatment.

Original languageEnglish
Pages (from-to)238-244
Number of pages7
JournalClinical Immunology
Volume133
Issue number2
DOIs
Publication statusPublished - Nov 2009

Keywords

  • AIDS
  • HAART
  • HIV
  • Soluble HLA class I molecules
  • Soluble HLA-G molecules

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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