Behavior of prealbumin in the acute phase of polymyalgia rheumatica treated with 6-methylprednisolone

Luca Puccetti, Amalia Lucchetti, Paola Barbieri, Daniela Melchiorre, Mauro Zuccotti, Gabriella Petrini, Giorgio Marotta, Elisabetta Remorini, Maria Laura Ciompi

Research output: Contribution to journalArticlepeer-review

Abstract

Serum levels of prealbumin, fibronectin, fibrinogen, α1-acid glycoprotein, C-reactive protein, immunoglobulins, and white blood cell count were prospectively studied in 33 patients affected by polymyalgia rheumatica during the first 45 days of treatment with 6-methylprednisolone. Almost all parameters considered, except for fibronectin and IgM, settled within the normal range fairly quickly, while prealbumin showed a specular course compared with the other reactants. This behavior reflected the improvement of clinical symptoms registered in all patients after steroid treatment. Finally, the genesis of the low baseline prealbumin levels found in polymyalgia rheumatica/giant cell arteritis and their behavior during treatment are discussed.

Original languageEnglish
Pages (from-to)251-258
Number of pages8
JournalLa Ricerca in Clinica e in Laboratorio
Volume19
Issue number1
DOIs
Publication statusPublished - Dec 1989

Keywords

  • Acute phase proteins
  • Polymyalgia rheumatica
  • Prealbumin
  • Protein energy malnutrition
  • Steroid treatment

ASJC Scopus subject areas

  • Clinical Biochemistry

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