Behavior of serum human major histocompatibility complex class I antigen levels in human immunodeficiency virus-infected patients during antiretroviral therapy: Correlation with clinical outcome

Giuseppe Murdaca, Paola Contini, Maurizio Setti, Paola Cagnati, Roberto Villa, Francesca Lantieri, Francesco Indiveri, Francesco Puppo

Research output: Contribution to journalArticlepeer-review

Abstract

Human major histocompatibility complex class I antigens (HLA-A, -B, and -C) are heterodimeric molecules composed of a α heavy chain noncovalently associated with an invariant protein known as β2-microglobulin. Beside being expressed on the membrane of the large majority of nucleated cells, HLA class I antigens are evident in serum (sHLA-I). We have previously detected a significant increase in the serum level of β2-microglobulin-associated HLA-I antigens in human immunodeficiency virus (HIV)-infected patients compared with HIV-negative controls. The introduction of highly active antiretroviral therapy (HAART) modified the clinical course of the disease and decreased the acquired immunodeficiency syndrome-related morbidity and mortality. Therefore, we measured the levels of sHLA-I antigens in 64 HIV-infected patients before and during HAART treatment and correlated them with the imunological and virological response to antiretroviral treatment. Serum sHLA-I antigen level was elevated in all HIV-infected patients before and significantly decreased after 36 months of HAART treatment, correlating with the decrease of plasma HIV-RNA level and with the increase of CD4+ T-lymphocyte number. These results suggest that the measurement of sHLA-I antigens serum level might represent a useful surrogate marker to monitor HIV-positive patients undergoing HAART treatment.

Original languageEnglish
Pages (from-to)894-900
Number of pages7
JournalHuman Immunology
Volume68
Issue number11
DOIs
Publication statusPublished - Nov 2007

Keywords

  • AIDS
  • HAART
  • HIV
  • Soluble HLA molecules

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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