Behavioral and EEG effects of synthetic enkephalin analogue (FK 33-824)

P. Bo; M. Maurelli; G. Nappi; F. Savoldi

Behavioral and EEG effects of synthetic enkephalin analogue (FK 33-824)

P. Bo, M. Maurelli, G. Nappi, F. Savoldi

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The behavioral and EEG changes induced by i.c.v. administration of FK 33-824, an active synthetic met-enkephalin analogue, were studied. The Monnier and Gangloff stereotaxic method was used in order to record cortical and deep structures. The effects of an opiate antagonist (naloxone) were examined. The aim of this research was to verify two hypotheses: whether or not there were any relationships between sedation state and EEG findings, and if any interactions could be detected between FK 33-824 and serotoninergic mechanisms.

Original language	English
Title of host publication	Farmaco, Edizione Scientifica
Pages	924-932
Number of pages	9
Volume	35
Edition	11
Publication status	Published - 1980

ASJC Scopus subject areas

Molecular Medicine

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