Behavioral and personality features in patients with lateralized Parkinson's disease

S. Piacentini, R. Versaci, L. Romito, F. Ferré, A. Albanese

Research output: Contribution to journalArticle


Background: Dopamine neurotransmission plays a key role in several brain activities, including motor, cognitive, and behavioral functions. Parkinson's disease (PD) typically begins with asymmetrical motor features related to asymmetrical dopamine denervation. This study was designed to examine whether distinct cognitive, behavioral, and personality features are related to this asymmetry. Methods: Fifty-six patients with mild PD and lateralized motor features were grouped according to dominant side of motor features and evaluated using a neuropsychological assessment focused on attention and executive functions, impulse control disorders, and personality inventory. Results: There were no differences in neuropsychological functions between patients with right and left lateralized PD, but differences occurred in personality features. Patients with motor impairment predominant on the left-hand side had prevalence of hypomania and conversion profile. Conclusions: This study suggests that side dominance of dopaminergic denervation may be related to personality features in patients with PD that could influence behavioral aspects.

Original languageEnglish
Pages (from-to)772-777
Number of pages6
JournalEuropean Journal of Neurology
Issue number5
Publication statusPublished - May 2011


  • Conversion disorder
  • Drug effects
  • Functional laterality
  • Impulsive behavior
  • Mood disorders
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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