TY - JOUR
T1 - Behavioral assessment of activity-based-anorexia
T2 - how cognition can become the drive wheel
AU - Lamanna, Jacopo
AU - Sulpizio, Simone
AU - Ferro, Mattia
AU - Martoni, Riccardo
AU - Abutalebi, Jubin
AU - Malgaroli, Antonio
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Anorexia Nervosa (AN) is a disorder with a dramatic impact on both the individual and society. Besides severe weight loss, excessive physical exercise and cognitive disturbances can be present in patients with AN as primary symptoms of the pathology or as secondary effects induced by physical and metabolic alterations. Mechanistic research in this field has taken advantage of a well characterized animal model, the activity-based anorexia model (ABA). ABA rodents and subjects with AN show clear behavioral and physiological similarities, but a throughout neurocognitive assessment of the model is still missing. Here, we review the available literature in the ABA field, highlighting similarities between ABA and AN at the behavioral, neurophysiological and cognitive level. Furthermore, based on availability, feasibility and adaptability of rodent behavioral protocols, we propose a set of neurocognitive assays that can be performed on the ABA. The proposed assessment represents an important step forward in the validation and extension of the ABA model, opening several routes of investigation related to AN and other eating disorders.
AB - Anorexia Nervosa (AN) is a disorder with a dramatic impact on both the individual and society. Besides severe weight loss, excessive physical exercise and cognitive disturbances can be present in patients with AN as primary symptoms of the pathology or as secondary effects induced by physical and metabolic alterations. Mechanistic research in this field has taken advantage of a well characterized animal model, the activity-based anorexia model (ABA). ABA rodents and subjects with AN show clear behavioral and physiological similarities, but a throughout neurocognitive assessment of the model is still missing. Here, we review the available literature in the ABA field, highlighting similarities between ABA and AN at the behavioral, neurophysiological and cognitive level. Furthermore, based on availability, feasibility and adaptability of rodent behavioral protocols, we propose a set of neurocognitive assays that can be performed on the ABA. The proposed assessment represents an important step forward in the validation and extension of the ABA model, opening several routes of investigation related to AN and other eating disorders.
KW - ABA
KW - Animal model
KW - Anorexia nervosa
KW - Cognitive functions
KW - Eating disorders
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U2 - 10.1016/j.physbeh.2019.01.016
DO - 10.1016/j.physbeh.2019.01.016
M3 - Review article
C2 - 30682332
AN - SCOPUS:85060636072
VL - 202
SP - 1
EP - 7
JO - Physiology and Behavior
JF - Physiology and Behavior
SN - 0031-9384
ER -