Behavioral disorders as unusual presentation of pediatric extraventricular neurocytoma: Report on two cases and review of the literature

Raffaella Messina, Maria Giuseppina Cefalo, Domitilla Elena Secco, Simona Cappelletti, Erika Rebessi, Andrea Carai, Giovanna Stefania Colafati, Francesca Diomedi Camassei, Antonella Cacchione, Carlo Efisio Marras, Angela Mastronuzzi

Research output: Contribution to journalArticle

Abstract

Background: Extraventricular neurocytomas (EVNs) are rare parenchymal brain tumors, distinct from central neurocytomas that are typically located within the supratentorial ventricular system. Seizures and headache represent the most common symptoms of extraventricular neurocytomas in the cerebral hemisphere both in adult and pediatric population. Case presentation: We describe two cases of pediatric EVN with clinical onset characterized by behavioral and attention deficit/ hyperactivity disorders. The association between behavioral/attention disorders in childhood and the presence of a frontal neurocytoma has never been described before. Furthermore, inappropriate levels of inattention, hyperactivity and impulsivity are common among the neurobehavioral and developmental disorders in childhood. We reviewed 43 pediatric cases of extraventricular neurocytoma included in the PubMed database and their clinical presentation, and we never found this unusual relationship. Conclusion: In childhood, the attention/hyperactivity disorders seem to be often over-diagnosed. When these deficits are more subtle and do not well-fit in a specific neurocognitive disorder, the clinicians should have a suspicion that they might mask the clinical features of a frontal lesion. This paper is focused on the clinical presentation of the extraventricular neurocytoma and the possible organic etiology of an attention and hyperactivity deficit.

Original languageEnglish
Article number242
JournalBMC Neurology
Volume14
Issue number1
DOIs
Publication statusPublished - Dec 19 2014

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Neurocytoma
Pediatrics
Impulsive Behavior
Cerebrum
Attention Deficit Disorder with Hyperactivity
Masks
PubMed
Brain Neoplasms
Headache
Seizures
Databases

Keywords

  • Attention deficit/hyperactivity disorders
  • Behavioral disorder
  • Extraventricular neurocytoma
  • Pediatric brain tumors

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Behavioral disorders as unusual presentation of pediatric extraventricular neurocytoma : Report on two cases and review of the literature. / Messina, Raffaella; Cefalo, Maria Giuseppina; Secco, Domitilla Elena; Cappelletti, Simona; Rebessi, Erika; Carai, Andrea; Colafati, Giovanna Stefania; Diomedi Camassei, Francesca; Cacchione, Antonella; Marras, Carlo Efisio; Mastronuzzi, Angela.

In: BMC Neurology, Vol. 14, No. 1, 242, 19.12.2014.

Research output: Contribution to journalArticle

Messina, Raffaella ; Cefalo, Maria Giuseppina ; Secco, Domitilla Elena ; Cappelletti, Simona ; Rebessi, Erika ; Carai, Andrea ; Colafati, Giovanna Stefania ; Diomedi Camassei, Francesca ; Cacchione, Antonella ; Marras, Carlo Efisio ; Mastronuzzi, Angela. / Behavioral disorders as unusual presentation of pediatric extraventricular neurocytoma : Report on two cases and review of the literature. In: BMC Neurology. 2014 ; Vol. 14, No. 1.
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