Behavioral disturbances in dementia and beyond: Time for a new conceptual frame?

Federico Ambrogio, Lucia Anna Martella, Patrizio Odetti, Fiammetta Monacelli

Research output: Contribution to journalReview articlepeer-review


Alzheimer’s disease and vascular dementia are estimated to be the most common causes of dementia, although mixed dementia could represent the most prevalent form of dementia in older adults aged more than 80 years. Behavioral disturbances are common in the natural history of dementia. However, so far, there is a paucity of studies that investigated the causal association between behavioral psychological symptoms of dementia and dementia sub-types, due to the high heterogeneity of methodology, study design and type of clinical assessment. To understand the scant evidence on such a relevant clinical issue, it could be hypothesized that a new shifting paradigm could result in a better identification of the relationship between behavioral disturbances and dementia. This narrative review provides an update of evidence on the behavioral patterns associated with different dementia sub-types and offers a potential future perspective as common ground for the development of new translational studies in the field of behavioral disturbances in dementia and the appropriateness of psychoactive treatments.

Original languageEnglish
Article number3647
JournalInternational Journal of Molecular Sciences
Issue number15
Publication statusPublished - Aug 1 2019


  • Alzheimer’s disease
  • Antipsychotics
  • Behavioral disturbances clusters
  • Mixed dementia
  • Vascular dementia

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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