Behavioral effects of morphine in mice: Role of experimental housing

Francesca R. D'Amato, Claudio Castellano

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Behavioral effects of morphine were assessed in isolated-timid Swiss mice, and were compared with those observed following morphine administration in nonaggressive-grouped subjects. For this purpose saline- and morphine- (0.5, 1.0, 2.5, and 5.0 mg/kg, IP) injected isolated-timid and nonaggressive-grouped mice interacting with a social partner were observed during a 4-min test. Three main points emerged from the results: a) in basal conditions, compared with social mice, in timid mice the offensive ambivalent behaviors were significantly less pronounced, while the defensive ambivalent behaviors (and all flight behaviors) were significantly more evident;b) 2.5 mg/kg of morphine increased offensive and decreased defensive ambivalent behaviors in timid mice;c) in social morphine (2.5 mg/kg) treatment increased defensive ambivalent behaviors and time spent in crouch. The results, which show that the behavioral effects of morphine depend on the state of the individual, are interpreted on the basis of the antiemotional properties of this opiate.

Original languageEnglish
Pages (from-to)361-365
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume34
Issue number2
DOIs
Publication statusPublished - 1989

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Morphine
Opiate Alkaloids

Keywords

  • Ambivalent behaviors
  • Emotionality
  • Isolation-induced timidity
  • Mice
  • Morphine

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Behavioral effects of morphine in mice : Role of experimental housing. / D'Amato, Francesca R.; Castellano, Claudio.

In: Pharmacology, Biochemistry and Behavior, Vol. 34, No. 2, 1989, p. 361-365.

Research output: Contribution to journalArticle

D'Amato, Francesca R. ; Castellano, Claudio. / Behavioral effects of morphine in mice : Role of experimental housing. In: Pharmacology, Biochemistry and Behavior. 1989 ; Vol. 34, No. 2. pp. 361-365.
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