Behavioral sensitization to heroin by cannabinoid pretreatment in the rat

Francesco E. Pontieri, Paola Monnazzi, Alessandra Scontrini, Francesca R. Buttarelli, Francesca R. Patacchioli

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The behavioral consequences of acute heroin challenge (0.5 mg/kg, s.c.) were measured in rats previously submitted to repeated administration of increasing doses of the synthetic cannabinoid receptor agonist, R( + )-[2,3-dihydro-5-methyl-3-[(morpholinyl)methyl]pyrrolo-[1,2,3-de]-1, 4-benzoxazinyl]-(1-naphthalenyl) methanone mesylate (WIN55212.2) (first day 2 mg/kg, second day 4 mg/kg, third day 8 mg/kg) or vehicle. Heroin administration to rats pretreated with vehicle produced catalepsy. The same dose of heroin in WIN55212.2-pretreated rats was followed by a marked increase of locomotor activity with stereotyped and non-stereotyped behaviors. These effects were blocked by the opioid receptor antagonist, naloxone. These findings indicate that pretreatment with WIN55212.2 produces cross-sensitization to heroin in the rat. These changes might reflect long-lasting changes of receptor population or transcriptional mechanisms in the mesolimbic system.

Original languageEnglish
JournalEuropean Journal of Pharmacology
Volume421
Issue number3
DOIs
Publication statusPublished - Jun 15 2001

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Cannabinoids
Heroin
Artificial Receptors
Cannabinoid Receptor Agonists
Catalepsy
Mesylates
Narcotic Antagonists
Locomotion
Naloxone
Population

Keywords

  • Drug abuse
  • Heroin
  • WIN55212.2

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Behavioral sensitization to heroin by cannabinoid pretreatment in the rat. / Pontieri, Francesco E.; Monnazzi, Paola; Scontrini, Alessandra; Buttarelli, Francesca R.; Patacchioli, Francesca R.

In: European Journal of Pharmacology, Vol. 421, No. 3, 15.06.2001.

Research output: Contribution to journalArticle

Pontieri, Francesco E. ; Monnazzi, Paola ; Scontrini, Alessandra ; Buttarelli, Francesca R. ; Patacchioli, Francesca R. / Behavioral sensitization to heroin by cannabinoid pretreatment in the rat. In: European Journal of Pharmacology. 2001 ; Vol. 421, No. 3.
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