TY - JOUR
T1 - Behavioral sensitization to WIN55212.2 in rats pretreated with heroin
AU - Pontieri, Francesco E.
AU - Monnazzi, Paola
AU - Scontrini, Alessandra
AU - Buttarelli, Francesca R.
AU - Patacchioli, Francesca R.
PY - 2001/4/13
Y1 - 2001/4/13
N2 - There is evidence of similarities and interactions between central opioid and cannabinoid system with reference to drug reinforcement and abuse. Here we demonstrate that repeated injection of heroin produces behavioral sensitization towards administration of the synthetic cannabinoid receptor agonist WIN55212.2 in the rat. These effects were blocked by both the cannabinoid antagonist SR141716A and the opioid antagonist naloxone. These findings suggest that repeated exposure to heroin produces neuroadaptative changes in brain circuits that contribute to mediate the behavioral consequences of acute administration of WIN55212.2. The present results expand our knowledge on the interactions between central opioid and cannabinoid systems with respect to drug abuse.
AB - There is evidence of similarities and interactions between central opioid and cannabinoid system with reference to drug reinforcement and abuse. Here we demonstrate that repeated injection of heroin produces behavioral sensitization towards administration of the synthetic cannabinoid receptor agonist WIN55212.2 in the rat. These effects were blocked by both the cannabinoid antagonist SR141716A and the opioid antagonist naloxone. These findings suggest that repeated exposure to heroin produces neuroadaptative changes in brain circuits that contribute to mediate the behavioral consequences of acute administration of WIN55212.2. The present results expand our knowledge on the interactions between central opioid and cannabinoid systems with respect to drug abuse.
KW - Behavior
KW - Drug abuse
KW - Heroin
KW - Sensitization
KW - WIN55212.2
UR - http://www.scopus.com/inward/record.url?scp=0035853507&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035853507&partnerID=8YFLogxK
U2 - 10.1016/S0006-8993(01)02158-8
DO - 10.1016/S0006-8993(01)02158-8
M3 - Article
C2 - 11292463
AN - SCOPUS:0035853507
VL - 898
SP - 178
EP - 180
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -