Behaviour of gastric mucin during pirenzepine treatment

A double-blind controlled study versus cimetidine

M. Guslandi, P. A. Testoni, E. Fesce

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Thirty duodenal ulcer patients were given either pirenzepine, 100 mg daily, or cimetidine, 1 g daily, for 6 weeks, in double-blind conditions. Before and after treatment gastric mucin fractions in the gastric juice were measured and a 'mucoprotective index' was calculated. No significant changes in the index were found after pirenzepine treatment, whereas a highly significant decrease (P <0.001) was observed after cimetidine treatment. The healing rate at endoscopical control was 60% with pirenzepine and 53% with cimetidine. The results show that pirenzepine is as effective as cimetidine in the treatment of duodenal ulcer. Furthermore pirenzepine promotes healing of peptic ulcer without affecting mucosal protective factors.

Original languageEnglish
Pages (from-to)714-718
Number of pages5
JournalCurrent Therapeutic Research
Volume27
Issue number5
Publication statusPublished - 1980

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Gastric Mucins
Pirenzepine
Cimetidine
Double-Blind Method
Duodenal Ulcer
Therapeutics
Gastric Juice
Peptic Ulcer

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Behaviour of gastric mucin during pirenzepine treatment : A double-blind controlled study versus cimetidine. / Guslandi, M.; Testoni, P. A.; Fesce, E.

In: Current Therapeutic Research, Vol. 27, No. 5, 1980, p. 714-718.

Research output: Contribution to journalArticle

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