Abstract
Thirty duodenal ulcer patients were given either pirenzepine, 100 mg daily, or cimetidine, 1 g daily, for 6 weeks, in double-blind conditions. Before and after treatment gastric mucin fractions in the gastric juice were measured and a 'mucoprotective index' was calculated. No significant changes in the index were found after pirenzepine treatment, whereas a highly significant decrease (P <0.001) was observed after cimetidine treatment. The healing rate at endoscopical control was 60% with pirenzepine and 53% with cimetidine. The results show that pirenzepine is as effective as cimetidine in the treatment of duodenal ulcer. Furthermore pirenzepine promotes healing of peptic ulcer without affecting mucosal protective factors.
| Original language | English |
|---|---|
| Pages (from-to) | 714-718 |
| Number of pages | 5 |
| Journal | Current Therapeutic Research |
| Volume | 27 |
| Issue number | 5 |
| Publication status | Published - 1980 |
ASJC Scopus subject areas
- Medicine(all)
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Guslandi, M., Testoni, P. A., & Fesce, E. (1980). Behaviour of gastric mucin during pirenzepine treatment: A double-blind controlled study versus cimetidine. Current Therapeutic Research, 27(5), 714-718.