Abstract
Thirty duodenal ulcer patients were given either pirenzepine, 100 mg daily, or cimetidine, 1 g daily, for 6 weeks, in double-blind conditions. Before and after treatment gastric mucin fractions in the gastric juice were measured and a 'mucoprotective index' was calculated. No significant changes in the index were found after pirenzepine treatment, whereas a highly significant decrease (P <0.001) was observed after cimetidine treatment. The healing rate at endoscopical control was 60% with pirenzepine and 53% with cimetidine. The results show that pirenzepine is as effective as cimetidine in the treatment of duodenal ulcer. Furthermore pirenzepine promotes healing of peptic ulcer without affecting mucosal protective factors.
| Original language | English |
|---|---|
| Pages (from-to) | 714-718 |
| Number of pages | 5 |
| Journal | Current Therapeutic Research |
| Volume | 27 |
| Issue number | 5 |
| Publication status | Published - 1980 |
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Behaviour of gastric mucin during pirenzepine treatment : A double-blind controlled study versus cimetidine. / Guslandi, M.; Testoni, P. A.; Fesce, E.
In: Current Therapeutic Research, Vol. 27, No. 5, 1980, p. 714-718.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Behaviour of gastric mucin during pirenzepine treatment
T2 - A double-blind controlled study versus cimetidine
AU - Guslandi, M.
AU - Testoni, P. A.
AU - Fesce, E.
PY - 1980
Y1 - 1980
N2 - Thirty duodenal ulcer patients were given either pirenzepine, 100 mg daily, or cimetidine, 1 g daily, for 6 weeks, in double-blind conditions. Before and after treatment gastric mucin fractions in the gastric juice were measured and a 'mucoprotective index' was calculated. No significant changes in the index were found after pirenzepine treatment, whereas a highly significant decrease (P <0.001) was observed after cimetidine treatment. The healing rate at endoscopical control was 60% with pirenzepine and 53% with cimetidine. The results show that pirenzepine is as effective as cimetidine in the treatment of duodenal ulcer. Furthermore pirenzepine promotes healing of peptic ulcer without affecting mucosal protective factors.
AB - Thirty duodenal ulcer patients were given either pirenzepine, 100 mg daily, or cimetidine, 1 g daily, for 6 weeks, in double-blind conditions. Before and after treatment gastric mucin fractions in the gastric juice were measured and a 'mucoprotective index' was calculated. No significant changes in the index were found after pirenzepine treatment, whereas a highly significant decrease (P <0.001) was observed after cimetidine treatment. The healing rate at endoscopical control was 60% with pirenzepine and 53% with cimetidine. The results show that pirenzepine is as effective as cimetidine in the treatment of duodenal ulcer. Furthermore pirenzepine promotes healing of peptic ulcer without affecting mucosal protective factors.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018885656&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0018885656
VL - 27
SP - 714
EP - 718
JO - Current Therapeutic Research - Clinical and Experimental
JF - Current Therapeutic Research - Clinical and Experimental
SN - 0011-393X
IS - 5
ER -