Behaviour of several 'progression markers' during the HIV-Ab seroconversion period. Comparison with later stages

P. Cordiali Fei, A. Massa, G. Prignano, M. Pietravalle, L. Alemanno, G. Vitelli, G. Palamara, A. Giglio, G. M. Gandolfo, G. Gentili, F. Caprilli, F. Ameglio

Research output: Contribution to journalArticlepeer-review


Two acute phase reactants, four cytokines, five soluble factors and lymphocyte subpopulations have been simultaneously evaluated in 16 subjects before and closely after the HIV-Ab seroconversion time. The same variables have also been determined in 50 HIV-Ab-negative high risk subjects, in 36 CDC II-III and in 30 CDC IV patients, utilizing a mixed longitudinal epidemiological model. The results show significant variations of few parameters in the early phases (increase: sCD8, β-2-Microglobulin, sIL-2R, sCD23, Neopterin, IFN-α; decrease: CD4+ lymphocytes). In the course of the disease, many others parameters progressively increase (IFN-ρ, IL-4, IL-6, acid-α1-glycoprotein, α1-antitrypsin) or decrease (B- and T-lymphocytes). Ferritin, in particular, highly increases only in CDC IV stage. These data may be useful to monitor patients during the entire course of their disease and to suggest the time elapsed from seroconversion.

Original languageEnglish
Pages (from-to)57-64
Number of pages8
JournalJournal of Biological Regulators and Homeostatic Agents
Issue number2
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Endocrinology
  • Physiology
  • Immunology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)


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