Behavioural and biochemical effects of the tremorgenic mycotoxin verruculogen

L. Intorre; F. Fornai; M. G. Alessandri; L. Lenzi; G. U. Corsini; G. Soldani

Behavioural and biochemical effects of the tremorgenic mycotoxin verruculogen

L. Intorre, F. Fornai, M. G. Alessandri, L. Lenzi, G. U. Corsini, G. Soldani

Research output: Contribution to journal › Article › peer-review

Abstract

The tremorgenic mycotoxin verruculogen administered intraperitoneally to Wistar rats and C57BL/6N mice produced a tremorgenic syndrome which lasted about 4 h and, although more severe in mice, was similar in both species. Striatal samples collected from animals sacrificed at 1, 4, 24 h and 7 days after treatment showed a significant (P <0.05 at 1 and 4 h) reduction of the dopamine metabolite 3-methoxytyramine (3-MT), while dopamine (DA) and other metabolites such as dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were found not to be significantly modified. The onset and the time course of the behavioural impairment observed are compatible with the duration of the biochemical changes measured in the striatum. A reduction in DA release rather than an effect on intraneuronal DA metabolism might account, at least in part, for the tremorgenic activity of verruculogen.

Original language	English
Pages (from-to)	119-125
Number of pages	7
Journal	Toxicological and Environmental Chemistry
Volume	46
Issue number	1-2
Publication status	Published - 1994

ASJC Scopus subject areas

Environmental Science(all)
Environmental Chemistry
Health, Toxicology and Mutagenesis
Toxicology

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abstract = "The tremorgenic mycotoxin verruculogen administered intraperitoneally to Wistar rats and C57BL/6N mice produced a tremorgenic syndrome which lasted about 4 h and, although more severe in mice, was similar in both species. Striatal samples collected from animals sacrificed at 1, 4, 24 h and 7 days after treatment showed a significant (P <0.05 at 1 and 4 h) reduction of the dopamine metabolite 3-methoxytyramine (3-MT), while dopamine (DA) and other metabolites such as dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were found not to be significantly modified. The onset and the time course of the behavioural impairment observed are compatible with the duration of the biochemical changes measured in the striatum. A reduction in DA release rather than an effect on intraneuronal DA metabolism might account, at least in part, for the tremorgenic activity of verruculogen.",

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T1 - Behavioural and biochemical effects of the tremorgenic mycotoxin verruculogen

AU - Intorre, L.

AU - Fornai, F.

AU - Alessandri, M. G.

AU - Lenzi, L.

AU - Corsini, G. U.

AU - Soldani, G.

PY - 1994

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N2 - The tremorgenic mycotoxin verruculogen administered intraperitoneally to Wistar rats and C57BL/6N mice produced a tremorgenic syndrome which lasted about 4 h and, although more severe in mice, was similar in both species. Striatal samples collected from animals sacrificed at 1, 4, 24 h and 7 days after treatment showed a significant (P <0.05 at 1 and 4 h) reduction of the dopamine metabolite 3-methoxytyramine (3-MT), while dopamine (DA) and other metabolites such as dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were found not to be significantly modified. The onset and the time course of the behavioural impairment observed are compatible with the duration of the biochemical changes measured in the striatum. A reduction in DA release rather than an effect on intraneuronal DA metabolism might account, at least in part, for the tremorgenic activity of verruculogen.

AB - The tremorgenic mycotoxin verruculogen administered intraperitoneally to Wistar rats and C57BL/6N mice produced a tremorgenic syndrome which lasted about 4 h and, although more severe in mice, was similar in both species. Striatal samples collected from animals sacrificed at 1, 4, 24 h and 7 days after treatment showed a significant (P <0.05 at 1 and 4 h) reduction of the dopamine metabolite 3-methoxytyramine (3-MT), while dopamine (DA) and other metabolites such as dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were found not to be significantly modified. The onset and the time course of the behavioural impairment observed are compatible with the duration of the biochemical changes measured in the striatum. A reduction in DA release rather than an effect on intraneuronal DA metabolism might account, at least in part, for the tremorgenic activity of verruculogen.

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