Behavioural and demographic factors associated with occurrence of non-melanoma skin cancer in organ transplant recipients

Luca Fania, Damiano Abeni, Ilaria Esposito, Gionata Spagnoletti, Franco Citterio, Jacopo Romagnoli, Marina Castriota, Francesco Ricci, Francesca Moro, Francesca Perino, Cinzia Mazzanti, Clara De Simone, Ketty Peris

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Non-melanoma skin cancers (NMSC) are the most common epithelial malignancies in organ transplantation recipients (OTRs). In Italy, incidence rates of post- transplantation NMSC are approximately 5% after 5 years and 10% after 10 years since organ transplantation. The objective was to describe risk factors associated with NMSC in a cohort of renal and liver transplant recipients, in a single-center longitudinal study.

METHODS: Renal and liver transplant patients, who underwent transplantation between June 1985 and December 2015, were visited for the first time or followed-up in a dedicated outpatient clinic every six months until July 2016.

RESULTS: We included 356 renal and 76 liver transplant patients. 108 OTRs (25.6%) presented 299 NMSC. 74 patients developed actinic keratosis (17.1%), 36 patients squamous cell carcinoma (8.5%), and 52 patients basal cell carcinoma (12.3%). Time from transplantation and kidney transplant were the main risk factors for NMSC. Higher incidences of all NMSC were observed in patients >60 years, males and smokers, while decreased incidences were detected in individuals with higher educational levels. Multiple logistic regression models confirmed that male gender (RR 3.3, P=0.001), cigarette smoking (RR 2.0, P=0.026), light eye color (RR 2.9, P=0.001), and family history of cancer (RR 1.8, P=0.042) were independently associated with NMSC.

CONCLUSIONS: Dermatological follow-up is important in OTRs, due to the higher risk of tumors and mainly NMSC. Clinical and environmental factors, including cigarette smoking, are useful in characterizing OTR with higher risk of NMSC.

Original languageEnglish
JournalGiornale Italiano di Dermatologia e Venereologia
DOIs
Publication statusE-pub ahead of print - Sep 24 2018

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Skin Neoplasms
Demography
Transplants
Organ Transplantation
Kidney
Liver
Incidence
Transplantation
Logistic Models
Smoking
Eye Color
Actinic Keratosis
Transplant Recipients
Neoplasms
Basal Cell Carcinoma
Ambulatory Care Facilities
Kidney Transplantation
Italy
Longitudinal Studies
Squamous Cell Carcinoma

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Behavioural and demographic factors associated with occurrence of non-melanoma skin cancer in organ transplant recipients. / Fania, Luca; Abeni, Damiano; Esposito, Ilaria; Spagnoletti, Gionata; Citterio, Franco; Romagnoli, Jacopo; Castriota, Marina; Ricci, Francesco; Moro, Francesca; Perino, Francesca; Mazzanti, Cinzia; De Simone, Clara; Peris, Ketty.

In: Giornale Italiano di Dermatologia e Venereologia, 24.09.2018.

Research output: Contribution to journalArticle

Fania, Luca ; Abeni, Damiano ; Esposito, Ilaria ; Spagnoletti, Gionata ; Citterio, Franco ; Romagnoli, Jacopo ; Castriota, Marina ; Ricci, Francesco ; Moro, Francesca ; Perino, Francesca ; Mazzanti, Cinzia ; De Simone, Clara ; Peris, Ketty. / Behavioural and demographic factors associated with occurrence of non-melanoma skin cancer in organ transplant recipients. In: Giornale Italiano di Dermatologia e Venereologia. 2018.
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abstract = "BACKGROUND: Non-melanoma skin cancers (NMSC) are the most common epithelial malignancies in organ transplantation recipients (OTRs). In Italy, incidence rates of post- transplantation NMSC are approximately 5{\%} after 5 years and 10{\%} after 10 years since organ transplantation. The objective was to describe risk factors associated with NMSC in a cohort of renal and liver transplant recipients, in a single-center longitudinal study.METHODS: Renal and liver transplant patients, who underwent transplantation between June 1985 and December 2015, were visited for the first time or followed-up in a dedicated outpatient clinic every six months until July 2016.RESULTS: We included 356 renal and 76 liver transplant patients. 108 OTRs (25.6{\%}) presented 299 NMSC. 74 patients developed actinic keratosis (17.1{\%}), 36 patients squamous cell carcinoma (8.5{\%}), and 52 patients basal cell carcinoma (12.3{\%}). Time from transplantation and kidney transplant were the main risk factors for NMSC. Higher incidences of all NMSC were observed in patients >60 years, males and smokers, while decreased incidences were detected in individuals with higher educational levels. Multiple logistic regression models confirmed that male gender (RR 3.3, P=0.001), cigarette smoking (RR 2.0, P=0.026), light eye color (RR 2.9, P=0.001), and family history of cancer (RR 1.8, P=0.042) were independently associated with NMSC.CONCLUSIONS: Dermatological follow-up is important in OTRs, due to the higher risk of tumors and mainly NMSC. Clinical and environmental factors, including cigarette smoking, are useful in characterizing OTR with higher risk of NMSC.",
author = "Luca Fania and Damiano Abeni and Ilaria Esposito and Gionata Spagnoletti and Franco Citterio and Jacopo Romagnoli and Marina Castriota and Francesco Ricci and Francesca Moro and Francesca Perino and Cinzia Mazzanti and {De Simone}, Clara and Ketty Peris",
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T1 - Behavioural and demographic factors associated with occurrence of non-melanoma skin cancer in organ transplant recipients

AU - Fania, Luca

AU - Abeni, Damiano

AU - Esposito, Ilaria

AU - Spagnoletti, Gionata

AU - Citterio, Franco

AU - Romagnoli, Jacopo

AU - Castriota, Marina

AU - Ricci, Francesco

AU - Moro, Francesca

AU - Perino, Francesca

AU - Mazzanti, Cinzia

AU - De Simone, Clara

AU - Peris, Ketty

PY - 2018/9/24

Y1 - 2018/9/24

N2 - BACKGROUND: Non-melanoma skin cancers (NMSC) are the most common epithelial malignancies in organ transplantation recipients (OTRs). In Italy, incidence rates of post- transplantation NMSC are approximately 5% after 5 years and 10% after 10 years since organ transplantation. The objective was to describe risk factors associated with NMSC in a cohort of renal and liver transplant recipients, in a single-center longitudinal study.METHODS: Renal and liver transplant patients, who underwent transplantation between June 1985 and December 2015, were visited for the first time or followed-up in a dedicated outpatient clinic every six months until July 2016.RESULTS: We included 356 renal and 76 liver transplant patients. 108 OTRs (25.6%) presented 299 NMSC. 74 patients developed actinic keratosis (17.1%), 36 patients squamous cell carcinoma (8.5%), and 52 patients basal cell carcinoma (12.3%). Time from transplantation and kidney transplant were the main risk factors for NMSC. Higher incidences of all NMSC were observed in patients >60 years, males and smokers, while decreased incidences were detected in individuals with higher educational levels. Multiple logistic regression models confirmed that male gender (RR 3.3, P=0.001), cigarette smoking (RR 2.0, P=0.026), light eye color (RR 2.9, P=0.001), and family history of cancer (RR 1.8, P=0.042) were independently associated with NMSC.CONCLUSIONS: Dermatological follow-up is important in OTRs, due to the higher risk of tumors and mainly NMSC. Clinical and environmental factors, including cigarette smoking, are useful in characterizing OTR with higher risk of NMSC.

AB - BACKGROUND: Non-melanoma skin cancers (NMSC) are the most common epithelial malignancies in organ transplantation recipients (OTRs). In Italy, incidence rates of post- transplantation NMSC are approximately 5% after 5 years and 10% after 10 years since organ transplantation. The objective was to describe risk factors associated with NMSC in a cohort of renal and liver transplant recipients, in a single-center longitudinal study.METHODS: Renal and liver transplant patients, who underwent transplantation between June 1985 and December 2015, were visited for the first time or followed-up in a dedicated outpatient clinic every six months until July 2016.RESULTS: We included 356 renal and 76 liver transplant patients. 108 OTRs (25.6%) presented 299 NMSC. 74 patients developed actinic keratosis (17.1%), 36 patients squamous cell carcinoma (8.5%), and 52 patients basal cell carcinoma (12.3%). Time from transplantation and kidney transplant were the main risk factors for NMSC. Higher incidences of all NMSC were observed in patients >60 years, males and smokers, while decreased incidences were detected in individuals with higher educational levels. Multiple logistic regression models confirmed that male gender (RR 3.3, P=0.001), cigarette smoking (RR 2.0, P=0.026), light eye color (RR 2.9, P=0.001), and family history of cancer (RR 1.8, P=0.042) were independently associated with NMSC.CONCLUSIONS: Dermatological follow-up is important in OTRs, due to the higher risk of tumors and mainly NMSC. Clinical and environmental factors, including cigarette smoking, are useful in characterizing OTR with higher risk of NMSC.

U2 - 10.23736/S0392-0488.18.06099-6

DO - 10.23736/S0392-0488.18.06099-6

M3 - Article

C2 - 30251802

JO - Giornale Italiano di Dermatologia e Venereologia

JF - Giornale Italiano di Dermatologia e Venereologia

SN - 0392-0488

ER -