Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 2038-2052 |
| Number of pages | 15 |
| Journal | Clin. Neurophysiol. |
| Volume | 130 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2019 |
Keywords
- Alzheimer's disease
- Compensatory mechanisms
- Event-related potentials
- Transcranial direct current stimulation
- Working memory
- adult
- aged
- alpha rhythm
- Alzheimer disease
- Article
- behavior change
- beta rhythm
- brain electrophysiology
- clinical article
- cognition
- controlled study
- dorsolateral prefrontal cortex
- electroencephalogram
- event related potential
- evoked cortical response
- female
- human
- male
- nerve excitability
- neuromodulation
- pilot study
- priority journal
- sham procedure
- task performance
- theta rhythm
- transcranial direct current stimulation
- very elderly
- working memory
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Behavioural and electrophysiological modulations induced by transcranial direct current stimulation in healthy elderly and Alzheimer's disease patients: A pilot study : Clinical Neurophysiology. / Cespón, J.; Rodella, C.; Miniussi, C. et al.
In: Clin. Neurophysiol., Vol. 130, No. 11, 2019, p. 2038-2052.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Behavioural and electrophysiological modulations induced by transcranial direct current stimulation in healthy elderly and Alzheimer's disease patients: A pilot study
T2 - Clinical Neurophysiology
AU - Cespón, J.
AU - Rodella, C.
AU - Miniussi, C.
AU - Pellicciari, M.C.
N1 - Cited By :1 Export Date: 10 February 2020 CODEN: CNEUF Correspondence Address: Cespón, J.; Cognitive Neuroscience Section, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni, 4, Italy; email: jesuscespon@gmail.com Funding details: GR-2011-02349998 Funding details: 655423-NIBSAD Funding text 1: This study was funded by the Italian Ministry of Health GR-2011-02349998 to MCP and the European Commission Marie-Skłodowska Curie Actions, Individual Fellowships; 655423-NIBSAD to JC. 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PY - 2019
Y1 - 2019
N2 - Objective: To investigate whether anodal and cathodal transcranial direct current stimulation (tDCS) can modify cognitive performance and neural activity in healthy elderly and Alzheimer's disease (AD) patients. Methods: Fourteen healthy elderly and twelve AD patients performed a working memory task during an electroencephalogram recording before and after receiving anodal, cathodal, and sham tDCS over the left dorsolateral prefrontal cortex. Behavioural performance, event-related potentials (P200, P300) and evoked cortical oscillations were studied as correlates of working memory. Results: Anodal tDCS increased P200 and P300 amplitudes in healthy elderly. Cathodal tDCS increased P200 amplitude and frontal theta activity between 150 and 300 ms in AD patients. Improved working memory after anodal tDCS correlated with increased P300 in healthy elderly. In AD patients, slight tendencies between enhanced working memory and increased P200 after cathodal tDCS were observed. Conclusions: Functional neural modulations were promoted by anodal tDCS in healthy elderly and by cathodal tDCS in AD patients. Significance: Interaction between tDCS polarity and the neural state (e.g., hyper-excitability exhibited by AD patients) suggests that appropriate tDCS parameters (in terms of tDCS polarity) to induce behavioural improvements should be chosen based on the participant's characteristics. Future studies using higher sample sizes should confirm and extend the present findings. © 2019 International Federation of Clinical Neurophysiology
AB - Objective: To investigate whether anodal and cathodal transcranial direct current stimulation (tDCS) can modify cognitive performance and neural activity in healthy elderly and Alzheimer's disease (AD) patients. Methods: Fourteen healthy elderly and twelve AD patients performed a working memory task during an electroencephalogram recording before and after receiving anodal, cathodal, and sham tDCS over the left dorsolateral prefrontal cortex. Behavioural performance, event-related potentials (P200, P300) and evoked cortical oscillations were studied as correlates of working memory. Results: Anodal tDCS increased P200 and P300 amplitudes in healthy elderly. Cathodal tDCS increased P200 amplitude and frontal theta activity between 150 and 300 ms in AD patients. Improved working memory after anodal tDCS correlated with increased P300 in healthy elderly. In AD patients, slight tendencies between enhanced working memory and increased P200 after cathodal tDCS were observed. Conclusions: Functional neural modulations were promoted by anodal tDCS in healthy elderly and by cathodal tDCS in AD patients. Significance: Interaction between tDCS polarity and the neural state (e.g., hyper-excitability exhibited by AD patients) suggests that appropriate tDCS parameters (in terms of tDCS polarity) to induce behavioural improvements should be chosen based on the participant's characteristics. Future studies using higher sample sizes should confirm and extend the present findings. © 2019 International Federation of Clinical Neurophysiology
KW - Alzheimer's disease
KW - Compensatory mechanisms
KW - Event-related potentials
KW - Transcranial direct current stimulation
KW - Working memory
KW - adult
KW - aged
KW - alpha rhythm
KW - Alzheimer disease
KW - Article
KW - behavior change
KW - beta rhythm
KW - brain electrophysiology
KW - clinical article
KW - cognition
KW - controlled study
KW - dorsolateral prefrontal cortex
KW - electroencephalogram
KW - event related potential
KW - evoked cortical response
KW - female
KW - human
KW - male
KW - nerve excitability
KW - neuromodulation
KW - pilot study
KW - priority journal
KW - sham procedure
KW - task performance
KW - theta rhythm
KW - transcranial direct current stimulation
KW - very elderly
KW - working memory
U2 - 10.1016/j.clinph.2019.08.016
DO - 10.1016/j.clinph.2019.08.016
M3 - Article
VL - 130
SP - 2038
EP - 2052
JO - Clin. Neurophysiol.
JF - Clin. Neurophysiol.
SN - 1388-2457
IS - 11
ER -