Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 2038-2052 |
| Number of pages | 15 |
| Journal | Clin. Neurophysiol. |
| Volume | 130 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2019 |
Keywords
- Alzheimer's disease
- Compensatory mechanisms
- Event-related potentials
- Transcranial direct current stimulation
- Working memory
- adult
- aged
- alpha rhythm
- Alzheimer disease
- Article
- behavior change
- beta rhythm
- brain electrophysiology
- clinical article
- cognition
- controlled study
- dorsolateral prefrontal cortex
- electroencephalogram
- event related potential
- evoked cortical response
- female
- human
- male
- nerve excitability
- neuromodulation
- pilot study
- priority journal
- sham procedure
- task performance
- theta rhythm
- transcranial direct current stimulation
- very elderly
- working memory
Fingerprint
Dive into the research topics of 'Behavioural and electrophysiological modulations induced by transcranial direct current stimulation in healthy elderly and Alzheimer's disease patients: A pilot study: Clinical Neurophysiology'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
Behavioural and electrophysiological modulations induced by transcranial direct current stimulation in healthy elderly and Alzheimer's disease patients: A pilot study : Clinical Neurophysiology. / Cespón, J.; Rodella, C.; Miniussi, C.; Pellicciari, M.C.
In: Clin. Neurophysiol., Vol. 130, No. 11, 2019, p. 2038-2052.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Behavioural and electrophysiological modulations induced by transcranial direct current stimulation in healthy elderly and Alzheimer's disease patients: A pilot study
T2 - Clinical Neurophysiology
AU - Cespón, J.
AU - Rodella, C.
AU - Miniussi, C.
AU - Pellicciari, M.C.
N1 - Cited By :1 Export Date: 10 February 2020 CODEN: CNEUF Correspondence Address: Cespón, J.; Cognitive Neuroscience Section, IRCCS Centro San Giovanni di Dio Fatebenefratelli, Via Pilastroni, 4, Italy; email: jesuscespon@gmail.com Funding details: GR-2011-02349998 Funding details: 655423-NIBSAD Funding text 1: This study was funded by the Italian Ministry of Health GR-2011-02349998 to MCP and the European Commission Marie-Skłodowska Curie Actions, Individual Fellowships; 655423-NIBSAD to JC. References: Antal, A., Alekseichuk, I., Bikson, M., Brockmöller, J., Brunoni, A.R., Chen, R., Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines (2017) Clin Neurophysiol, 128 (9), pp. 1774-1809; Antonenko, D., Külzow, N., Sousa, A., Prehn, K., Grittner, U., Flöel, A., Neuronal and behavioral effects of multi-day brain stimulation and memory training (2018) Neurobiol Aging, 61, pp. 245-254; Au, J., Karsten, C., Buschkuehl, M., Jaeggi, S.M., Optimizing transcranial direct current stimulation protocols to promote long-term learning (2017) J Cogn Enhanc, 1, pp. 65-72; Baddeley, A., Working memory: looking back and looking forward (2003) Nat Rev Neurosci, 4, pp. 829-839; Baudic, S., Dalla Barba, G., Thibaudet, M.C., Smagghec, A., Remyd, P., Traykov, L., Executive function deficits in early Alzheimer's disease and their relations with episodic memory (2006) Arch Clin Neuropsychol, 21, pp. 15-21; Benjamini, Y., Hochberg, Y., Controlling the false discovery rate: a practical and powerful approach to multiple testing (1995) J R Stat Soc Ser B, 57, pp. 289-300; Benwell, C.S.Y., Learmonth, G., Miniussi, C., Harvey, M., Thut, G., Non-linear effects of transcranial direct current stimulation as a function of individual baseline performance: Evidence from biparietal tDCS influence on lateralized attention bias (2015) Cortex, 69, pp. 152-165; Bergmann, T.O., Karabanov, A., Hartwigsen, G., Thielscher, A., Siebner, H.R., Combining non-invasive transcranial brain stimulation with neuroimaging and electrophysiology: Current approaches and future perspectives (2016) Neuroimage, 140, pp. 4-19; Berryhill, M.E., Jones, K.T., tDCS selectively improves working memory in older adults with more education (2012) Neurosci Lett, 521 (2), pp. 148-151; Boggio, P.S., Khoury, L.P., Martins, D.C., Martins, O.E., de Macedo, E.C., Fregni, F., Temporal cortex direct current stimulation enhances performance on a visual recognition memory task in Alzheimer disease (2009) J Neurol Neurosurg Psychiatry, 80 (4), pp. 444-447; Bortoletto, M., Pellicciari, M.C., Rodella, C., Miniussi, C., The interaction with task-induced activity is more important than polarization: a tDCS study (2015) Brain Stimul, 8 (2), pp. 269-276; Bracco, L., Giovannelli, F., Bessi, V., Borgheresi, A., Di Tullio, A., Sorbi, S., Zaccara, G., Cincotta, M., Mild cognitive impairment: loss of linguistic task-induced changes in motor cortex excitability (2009) Neurology, 72 (10), pp. 928-934; Button, K.S., Ioannidis, J.P., Mokrysz, C., Nosek, B.A., Flint, J., Robinson, E.S., Munafò, M.R., Power failure: why small sample size undermines the reliability of neuroscience (2013) Nat Rev Neurosci, 14 (5), pp. 365-376; Bystad, M., Grønli, O., Rasmussen, I.D., Gundersen, N., Nordvang, L., Wang-Iversen, H., Transcranial direct current stimulation as a memory enhancer in patients with Alzheimer's disease: a randomized, placebo-controlled trial (2016) Alzheimers Res Ther, 8 (1), p. 13; Cespón, J., Galdo-Álvarez, S., Pereiro, A.X., Díaz, F., Differences between mild cognitive impairment subtypes as indicated by event-related potential correlates of cognitive and motor processes in a Simon task (2015) J Alzheimers Dis, 43 (2), pp. 631-647; Cespón, J., Miniussi, C., Pellicciari, M.C., Interventional programmes to improve cognition during healthy and pathological ageing: cortical modulations and evidence for brain plasticity (2018) Ageing Res Rev, 43, pp. 81-98; Cespón, J., Rodella, C., Rossini, P., Miniussi, C., Pellicciari, M.C., Anodal transcranial direct current stimulation promotes frontal compensatory mechanisms in healthy elderly subjects (2017) Front Aging Neurosci, 9, p. 420; Chan, R.C., Shum, D., Toulopoulou, T., Chen, E.Y., Assessment of executive functions: review of instruments and identification of critical issues (2008) Arch Clin Neuropsychol, 23 (2), pp. 201-216; Cid-Fernández, S., Lindín, M., Díaz, F., Stimulus-locked lateralized readiness potential and performance: useful markers for differentiating between amnestic subtypes of mild cognitive impairment (2017) J Prev Alzheimers Dis, 4 (1), pp. 21-28; Cohen, J., Statistical power analysis for the behavioral sciences (1988), Routledge Academic New York, NY; Cotelli, M., Manenti, R., Brambilla, M., Petesi, M., Rosini, S., Ferrari, C., Zanetti, O., Miniussi, C., Anodal tDCS during face-name associations memory training in Alzheimer's patients (2014) Front Aging Neurosci, 6, p. 38; Creutzfeldt, O.D., Fromm, G.H., Kapp, H., Influence of transcortical dc currents on cortical neuronal activity (1962) Exp Neurol, 5, pp. 436-452; Daffner, K.R., Chong, H., Sun, X., Tarbi, E.C., Riis, J.L., McGinnis, S.M., Holcomb, P.J., Mechanisms underlying age- and performance differences in working memory (2011) J Cogn Neurosci, 23, pp. 1298-1314; Davis, S.W., Kragel, J.E., Madden, D.J., Cabeza, R., The architecture of cross-hemispheric communication in the aging brain: linking behavior to functional and structural connectivity (2012) Cereb Cortex, 22 (1), pp. 232-242; De Putter, L.M., Vanderhasselt, M.A., Baeken, C., De Raedt, R., Koster, E.H., Combining tDCS and working memory training to down regulate state rumination: a single-session double blind sham controlled trial (2015) Cogn Ther Res, 39 (6), pp. 754-765; Diamond, A., Executive functions (2013) Annu Rev Psychol, 64, pp. 135-168; Di Lazzaro, V., Oliviero, A., Pilato, F., Saturno, E., Dileone, M., Marra, C., Daniele, A., Tonali, P.A., Motor cortex hyperexcitability to transcranial magnetic stimulation in Alzheimer's disease (2004) J Neurol Neurosurg Psychiatry., 75 (4), pp. 555-559; Dockery, C.A., Hueckel-Weng, R., Birbaumer, N., Plewnia, C., Enhancement of planning ability by transcranial direct current stimulation (2009) J Neurosci, 29, pp. 7271-7279; Engel, A.K., Fries, P., Beta-band oscillations - signalling the status quo? (2010) Curr Opin Neurobiol, 20, pp. 156-165; Fertonani, A., Miniussi, C., Transcranial electrical stimulation: what we know and do not know about mechanisms (2017) Neuroscientist, 23 (2), pp. 109-123; Ferreri, F., Pasqualetti, P., Määttä, S., Ponzo, D., Guerra, A., Bressi, F., Chiovenda, P., Rossini, P.M., Motor cortex excitability in Alzheimer's disease: a transcranial magnetic stimulation follow-up study (2011) Neurosci Lett., 492 (2), pp. 94-98; Finnigan, S., O'Connell, R.G., Cummins, T.D., Broughton, M., Robertson, I.H., ERP measures indicate both attention and working memory encoding decrements in aging (2011) Psychophysiology, 48 (5), pp. 601-611; Folstein, M.F., Folstein, S.E., McHugh, P.R., “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician (1975) J Psychiatr Res, 12 (3), pp. 189-198; Fregni, F., Boggio, P.S., Nitsche, M., Bermpohl, F., Antal, A., Feredoes, E., Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory (2005) Exp Brain Res, 166, pp. 23-30; Friedman, D., Kazmerski, V., Fabiani, M., An overview of age-related changes in the scalp distribution of P3b (1997) Electroencephalogr Clin Neurophysiol, 104 (6), pp. 498-513; Hall, A.M., Throesch, B.T., Buckingham, S.C., Markwardt, S.J., Peng, Y., Wang, Q., Hoffman, D.A., Roberson, E.D., Tau-dependent Kv4.2 depletion and dendritic hyperexcitability in a mouse model of Alzheimer's disease (2015) J Neurosci., 35, pp. 6221-6230; Hasselmo, M.E., The role of acetylcholine in learning and memory (2006) Curr Opin Neurobiol, 16 (6), pp. 710-715; Heinen, K., Sagliano, L., Candini, M., Husain, M., Cappelletti, M., Zokaei, N., Cathodal transcranial direct current stimulation over posterior parietal cortex enhances distinct aspects of visual working memory (2016) Neuropsychologia, 87, pp. 35-42; Hill, A.T., Fitzgerald, P.B., Hoy, K.E., Effects of anodal transcranial direct current stimulation on working memory: a systematic review and meta-analysis of findings from healthy and neuropsychiatric populations (2016) Brain Stimul, 9 (2), pp. 197-208; Horvath, J.C., Carter, O., Forte, J.D., Transcranial direct current stimulation: five important issues we aren't discussing (but probably should be) (2014) Front Syst Neurosci, 8, p. 2; Hsu, T.Y., Juan, C.H., Tseng, P., Individual differences and state-dependent responses in transcranial direct current stimulation (2016) Front Hum Neurosci, 10, p. 643; Hsu, W.Y., Ku, Y., Zanto, T.P., Gazzaley, A., Effects of non-invasive brain stimulation on cognitive function in healthy aging and Alzheimer's disease: a systematic review and meta-analysis (2015) Neurobiol Aging, 36 (8), pp. 2348-2359; Itthipuripat, S., Wessel, J.R., Aron, A., Frontal theta is a signature of successful working memory manipulation (2013) Exp Brain Res, 224 (2), pp. 255-262; Jantz, T.K., Katz, B., Reuter-Lorenz, P.A., Uncertainty and promise: the effects of transcranial direct current stimulation on working memory (2016) Curr Behav Neurosci Rep, 3 (2), pp. 109-121; Jones, K.T., Stephens, J.A., Alam, M., Bikson, M., Berryhill, M.E., Longitudinal neurostimulation in older adults improves working memory (2015) PLoS One, 10 (4); Kamijo, K., Hayashi, Y., Sakai, T., Yahiro, T., Tanaka, K., Nishihira, Y., Acute effects of aerobic exercise on cognitive function in older adults (2009) J Gerontol B Psychol Sci Soc Sci, 64 (3), pp. 356-363; Keeser, D., Padberg, F., Reisinger, E., Pogarell, O., Kirsch, V., Palm, U., Prefrontal direct current stimulation modulates resting EEG and event-related potentials in healthy subjects: a standardized low resolution tomography (sLORETA) study (2011) Neuroimage, 55 (2), pp. 644-657; Khedr, E.M., Ahmed, M.A., Darwish, E.S., Ali, A.M., The relationship between motor cortex excitability and severity of Alzheimer's disease: a transcranial magnetic stimulation study (2011) Clin Neurophysiol, 41 (3), pp. 107-113; Khedr, E.M., El Gamal, N.F., El-Fetoh, N.A., Khalifa, H., Ahmed, E.M., Ali, A.M., Noaman, M., Karim, A.A., A double-blind randomized clinical trial on the efficacy of cortical direct current stimulation for the treatment of Alzheimer's disease (2014) Front. Aging Neurosci., 6, p. 275; Kirova, A.-M., Bays, R.B., Lagalwar, S., Working memory and executive function decline across normal aging, mild cognitive impairment, and Alzheimer's disease (2015) BioMed Res Int, 2015, pp. 1-9; Kim, J.H., Kim, D.W., Chang, W.H., Kim, Y.H., Kim, K., Im, C.H., Inconsistent outcomes of transcranial direct current stimulation can originate from anatomical differences among individuals: electric field stimulation using individual MRI data (2014) Neurosci Lett, 564, pp. 6-10; Klimesch, W., EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis (1999) Brain Res Rev, 29, pp. 169-195; Klimesch, W., Schack, B., Sauseng, P., The functional significance of theta and upper alpha oscillations (2005) Exp Psychol, 52 (2), pp. 99-108; Kumar, S., Zomorrodi, R., Ghazala, Z., Goodman, M.S., Blumberger, D.M., Cheam, A., Extent of dorsolateral prefrontal cortex plasticity and its association with working memory in patients with Alzheimer disease (2017) JAMA Psychiatry, 74 (12), pp. 1266-1274; Lefaucheur, J.P., Antal, A., Ayache, S.S., Benninger, D.H., Brunelin, J., Cogiamanian, F., Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS) (2017) Clin Neurophysiol, 128 (1), pp. 56-92; Levy, R., Goldman-Rakic, P.S., Segregation of working memory functions within the dorsolateral prefrontal cortex (2000) Exp Brain Res, 133, pp. 23-32; Li, B.-Y., Tang, H.-D., Chen, S.-D., Retrieval deficiency in brain activity of working memory in amnestic mild cognitive impairment patients: a brain event-related potentials study (2016) Front Aging Neurosci, 8, p. 54; List, J., Kübke, J.C., Lindenberg, R., Külzow, N., Kerti, L., Witte, V., Flöel, A., Relationship between excitability, plasticity and thickness of the motor cortex in older adults (2013) Neuroimage, 83, pp. 809-816; López Zunini, R.A., Knoefel, F., Lord, C., Dzuali, F., Breau, M., Sweet, L., Goubran, R., Taler, V., Event-related potentials elicited during working memory are altered in mild cognitive impairment (2016) Int J Psychophysiol, 109, pp. 1-8; Mangia, A.L., Pirini, M., Cappello, A., Transcranial direct current stimulation and power spectral parameters: a tDCS/EEG co-registration study (2014) Front Hum Neurosci, 8, p. 601; McDonald, J.H., Handbook of Biological Statistics (2014), 3rd ed. Sparky House Publishing Baltimore, Maryland; McEvoy, L.K., Pellouchoud, E., Smith, M.E., Gevins, A., Neurophysiological signals of working memory in normal aging (2001) Cogn Brain Res, 11 (3), pp. 363-376; McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., Stadlan, E.M., Clinical diagnosis of Alzheimer's disease. Report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer's disease (1984) Neurology, 34 (7); Miller, J., Berger, B., Sauseng, P., Anodal transcranial direct current stimulation (tDCS) increases frontal-midline theta activity in the human EEG: a preliminary investigation of non-invasive stimulation (2015) Neurosci Lett, 588, pp. 114-119; Miniussi, C., Cappa, S.F., Cohen, L.G., Floel, A., Fregni, F., Nitsche, M.A., Efficacy of repetitive transcranial magnetic stimulation/transcranial direct current stimulation in cognitive neurorehabilitation (2008) Brain Stimul, 1 (4), pp. 326-336; Miniussi, C., Harris, J.A., Ruzzoli, M., Modelling non-invasive brain stimulation in cognitive neuroscience (2013) Neurosci Biobehav Rev, 37 (8), pp. 1702-1712; Miyake, A., Friedman, N.P., The nature and organization of individual differences in Executive functions: four general conclusions (2012) Curr Dir Psychol Sci, 21 (1), pp. 8-14; Miyake, A., Friedman, N.P., Emerson, M.J., Witzki, A.H., Howerter, A., Wager, T.D., The unity and diversity of executive functions and their contributions to complex “Frontal Lobe” tasks: a latent variable analysis (2000) Cogn Psychol, 41 (1), pp. 49-100; Moliadze, V., Atalay, D., Antal, A., Paulus, W., Close to threshold transcranial electrical stimulation preferentially activates inhibitory networks before switching to excitation with higher intensities (2012) Brain Stimul, 5 (4), pp. 505-511; Motohashi, N., Yamaguchi, M., Fujii, T., Kitahara, Y., Mood and cognitive function following repeated transcranial direct current stimulation in healthy volunteers: a preliminary report (2013) Neurosci Res, 77 (1), pp. 64-69; Mylius, V., Jung, M., Menzler, K., Haag, A., Khader, P.H., Oertel, W.H., Effects of transcranial direct current stimulation on pain perception and working memory (2012) Eur J Pain, 16 (7), pp. 974-982; Nilsson, J., Lebedev, A.V., Rydstrom, A., Lovden, M., Direct current stimulation does little to improve the outcome of working memory training in older adults (2017) Psychol Sci, 28, pp. 907-920; Nitsche, M.A., Paulus, W., Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation (2000) J Physiol, 527 (3), pp. 633-639; Nitsche, M.A., Paulus, W., Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans (2001) Neurology, 57, pp. 1899-1901; O'Brien, J.L., Edwards, J.D., Maxfield, N.D., Peronto, C.L., Williams, V.A., Lister, J.J., Cognitive training and selective attention in the aging brain: an electrophysiological study (2013) Clin Neurophysiol, 124, pp. 2198-2208; Oldfield, R.C., The assessment and analysis of handedness: the Edinburgh inventory (1971) Neuropsychologia, 9, pp. 97-113; Palop, J.J., Chin, J., Roberson, E.D., Wang, J., Thwin, M.T., Bien-Ly, N., Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease (2007) Neuron, 55, pp. 697-711; Park, D.C., Lautenschlager, G., Hedden, T., Davidson, N.S., Smith, A.D., Smith, P.K., Models of visuospatial and verbal memory across the adult life span (2002) Psychol Aging, 17, pp. 299-320; Park, S.H., Seo, J.H., Kim, Y.H., Ko, M.H., Long-term effects of transcranial direct current stimulation combined with computer-assisted cognitive training in healthy older adults (2014) Neuroreport, 25 (2), pp. 122-126; Patel, S.H., Azzam, P.N., Characterization of N200 and P300: selected studies of the event-related potential (2005) Int J Med Sci, 2, pp. 147-154; Pavlov, Y.G., Kotchoubey, B., EEG correlates of working memory performance in females (2017) BMC Neurosci, 18 (1), p. 26; Peich, M.C., Husain, M., Bays, P.M., Age-related decline of precision and binding in visual working memory (2013) Psychol Aging, 28, pp. 729-743; Pellicciari, M.C., Miniussi, C., Transcranial direct current stimulation in neurodegenerative disorders (2018) J ECT; Pennisi, G., Ferri, R., Lanza, G., Cantone, M., Pennisi, M., Puglisi, V., Transcranial magnetic stimulation in Alzheimer's disease: a neurophysiological marker of cortical hyperexcitability (2011) J Neural Transm, 118, p. 587; Polich, J., Updating P300: an integrative theory of P3a and P3b (2007) Clin Neurophysiol, 118 (10), pp. 2128-2148; Polich, J., Corey-Bloom, J., Alzheimer's disease and P300: review and evaluation of task and modality (2005) Curr Alzheimer Res, 5, pp. 515-525; Ramos-Goicoa, M., Galdo-Álvarez, S., Díaz, F., Zurrón, M., Effect of normal aging and of mild cognitive impairment on event-related potentials to a Stroop color-word task (2016) J Alzheimers Dis, 52 (4), pp. 1487-1501; Rossini, P.M., Rossi, S., Babiloni, C., Polich, J., Clinical neurophysiology of aging brain: from normal aging to neurodegeneration (2007) Prog Neurobiol, 83 (6), pp. 375-400; Saliasi, E., Geerligs, L., Lorist, M.M., Maurits, N.M., The relationship between P3 amplitude and working memory performance differs in young and older adults (2013) PLoS One, 8 (5); Scala, F., Fusco, S., Ripoli, C., Piacentini, R., Li Puma, D.D., Spinelli, M., Laezza, F., D'Ascenzo, M., Intraneuronal Abeta accumulation induces hippocampal neuron hyperexcitability through A-type K(+) current inhibition mediated by activation of caspases and GSK-3 (2015) Neurobiol Aging., 36, pp. 886-900; Schneider-Garces, N.J., Gordon, B.A., Brumback-Peltz, C.R., Shin, E., Lee, Y., Sutton, B.P., Maclin, E.L., Fabiani, M., Span, CRUNCH, and beyond: working memory capacity and the aging brain (2010) J Cogn Neurosci, 22, pp. 655-669; Sellers, K.K., Mellin, J.M., Lustenberger, C.M., Boyle, M.R., Lee, W.H., Peterchev, A.V., Transcranial direct current stimulation (tDCS) of frontal cortex decreases performance on the WAIS-IV intelligence test (2015) Behav Brain Res, 290, pp. 32-44; Silvanto, J., Muggleton, N., Walsh, V., State-dependency in brain stimulation studies of perception and cognition (2008) Trends Cogn Sci, 12, pp. 447-454; Stephens, J.A., Berryhill, M.E., Older adults improve on everyday tasks after working memory training and neurostimulation (2016) Brain Stimul, 9, pp. 553-559; Suemoto, C.K., Apolinario, D., Nakamura-Palacios, E.M., Lopes, L., Leite, R.E., Sales, M.C., Effects of a non-focal plasticity protocol in apathy in moderate Alzheimer's disease: a randomized, double-blind, sham-controlled trial (2014) Brain Stimul, 7, pp. 308-313; Summers, J.J., Kang, N., Cauraugh, J.H., Does transcranial direct current stimulation enhance cognitive and motor functions in the ageing brain? A systematic review and meta-analysis (2016) Ageing Res Rev, 25, pp. 42-54; Tatti, E., Rossi, S., Innocenti, I., Rossi, A., Santarnecchi, E., Non-invasive brain stimulation of the aging brain: State of the art and future perspectives (2016) Ageing Res Rev, 29, pp. 66-89; Tseng, P., Hsu, T.Y., Chang, C.F., Tzeng, O.J., Hung, D.L., Muggleton, N.G., Unleashing potential: transcranial direct current stimulation over the right posterior parietal cortex improves change detection in low-performing individuals (2012) J Neurosci, 32 (31), pp. 10554-10561; Tusch, E.S., Brittany, R.A., Ryan, E., Holcomb, P.J., Mohammed, A.H., Daffner, K.R., Changes in neural activity underlying working memory after computerized cognitive training in older adults (2016) Front Aging Neurosci, 8, p. 255; Wang, R., Kamezawa, R., Watanabe, A., Iramina, K., EEG alpha power change during working memory encoding in adults with different memory performance levels (2017) Conf Proc IEEE Eng Med Biol Soc, pp. 982-985; Weintraub, S., Wicklund, A.H., Salmon, D.P., The neuropsychological profile of Alzheimer disease (2012) Cold Spring Harb Perspect Med, 2 (4); Wild-Wall, N., Falkenstein, M., Gajewski, P.D., Age-related differences in working memory performance in a 2-back task (2011) Front Psychol, 2, p. 186; Wilhelm, O., Hildebrandt, A., Oberauer, K., What is working memory capacity, and how can we measure it? (2013) Front Psychol, 4, p. 433; Woods, A.J., Antal, A., Bikson, M., Boggio, P.S., Brunoni, A.R., Celnik, P., A technical guide to tDCS, and related non-invasive brain stimulation tools (2016) Clin Neurophysiol, 127, pp. 1031-1048; Zakrzewska, M.Z., Brzezicka, A., Working memory capacity as a moderator of load-related frontal midline theta variability in Sternberg task (2014) Front Hum Neurosci, 8, p. 399; Zhao, X., Zhou, R., Fu, L., Working memory updating function training influenced brain activity (2013) PLoS One, 8 (8); Zurrón, M., Lindín, M., Cespón, J., Cid-Fernández, S., Galdo-Álvarez, S., Ramos-Goicoa, M., Effect of mild cognitive impairment on event-related potentials (ERP) parameters related to executive control tasks (2018) Front Psychol, 9, p. 842
PY - 2019
Y1 - 2019
N2 - Objective: To investigate whether anodal and cathodal transcranial direct current stimulation (tDCS) can modify cognitive performance and neural activity in healthy elderly and Alzheimer's disease (AD) patients. Methods: Fourteen healthy elderly and twelve AD patients performed a working memory task during an electroencephalogram recording before and after receiving anodal, cathodal, and sham tDCS over the left dorsolateral prefrontal cortex. Behavioural performance, event-related potentials (P200, P300) and evoked cortical oscillations were studied as correlates of working memory. Results: Anodal tDCS increased P200 and P300 amplitudes in healthy elderly. Cathodal tDCS increased P200 amplitude and frontal theta activity between 150 and 300 ms in AD patients. Improved working memory after anodal tDCS correlated with increased P300 in healthy elderly. In AD patients, slight tendencies between enhanced working memory and increased P200 after cathodal tDCS were observed. Conclusions: Functional neural modulations were promoted by anodal tDCS in healthy elderly and by cathodal tDCS in AD patients. Significance: Interaction between tDCS polarity and the neural state (e.g., hyper-excitability exhibited by AD patients) suggests that appropriate tDCS parameters (in terms of tDCS polarity) to induce behavioural improvements should be chosen based on the participant's characteristics. Future studies using higher sample sizes should confirm and extend the present findings. © 2019 International Federation of Clinical Neurophysiology
AB - Objective: To investigate whether anodal and cathodal transcranial direct current stimulation (tDCS) can modify cognitive performance and neural activity in healthy elderly and Alzheimer's disease (AD) patients. Methods: Fourteen healthy elderly and twelve AD patients performed a working memory task during an electroencephalogram recording before and after receiving anodal, cathodal, and sham tDCS over the left dorsolateral prefrontal cortex. Behavioural performance, event-related potentials (P200, P300) and evoked cortical oscillations were studied as correlates of working memory. Results: Anodal tDCS increased P200 and P300 amplitudes in healthy elderly. Cathodal tDCS increased P200 amplitude and frontal theta activity between 150 and 300 ms in AD patients. Improved working memory after anodal tDCS correlated with increased P300 in healthy elderly. In AD patients, slight tendencies between enhanced working memory and increased P200 after cathodal tDCS were observed. Conclusions: Functional neural modulations were promoted by anodal tDCS in healthy elderly and by cathodal tDCS in AD patients. Significance: Interaction between tDCS polarity and the neural state (e.g., hyper-excitability exhibited by AD patients) suggests that appropriate tDCS parameters (in terms of tDCS polarity) to induce behavioural improvements should be chosen based on the participant's characteristics. Future studies using higher sample sizes should confirm and extend the present findings. © 2019 International Federation of Clinical Neurophysiology
KW - Alzheimer's disease
KW - Compensatory mechanisms
KW - Event-related potentials
KW - Transcranial direct current stimulation
KW - Working memory
KW - adult
KW - aged
KW - alpha rhythm
KW - Alzheimer disease
KW - Article
KW - behavior change
KW - beta rhythm
KW - brain electrophysiology
KW - clinical article
KW - cognition
KW - controlled study
KW - dorsolateral prefrontal cortex
KW - electroencephalogram
KW - event related potential
KW - evoked cortical response
KW - female
KW - human
KW - male
KW - nerve excitability
KW - neuromodulation
KW - pilot study
KW - priority journal
KW - sham procedure
KW - task performance
KW - theta rhythm
KW - transcranial direct current stimulation
KW - very elderly
KW - working memory
U2 - 10.1016/j.clinph.2019.08.016
DO - 10.1016/j.clinph.2019.08.016
M3 - Article
VL - 130
SP - 2038
EP - 2052
JO - Clin. Neurophysiol.
JF - Clin. Neurophysiol.
SN - 1388-2457
IS - 11
ER -