This case report describes a woman affected by typical, probable Progressive Supranuclear Palsy (PSP) precedeed and associated to behavioural and psychological symptoms in dementia (BPSD). The onset of psychiatric disorders has been earlier, about thirty years before extrapyramidal syndrome. At the age of 61, she presented cognitive impairment and the first appearance of neurological signs of PSP. At the time of observation, the patient had 55 score at PSP rating scale and showed a persecutory and guilty delusion associated with hallucinations and disperceptions. She had neuropsychological impairment, in particularly long-term memory loss, deficit of working memory, executive functions and attention. Based on this case, we suggest the possibility of pathogenetic correlation between cognitive, extrapyramidal and psychiatric disorders. The imbalance of dopaminergic system could be implicated in BPSD and extrapyramidal syndrome and this could represent a common biochemical basis. The extrapyramidal syndrome could be caused by the degeneration of D2 receptors which are located in basal ganglia, while cognitive impairment could be connected with interruptions of striatal-thalamic-cortical pathways. The dopaminergic imbalance which derives from neuronal loss could also influence other dopaminergic receptors (D3 and D4), implicated in the outcome of psychiatric and behavioural symptoms.
|Number of pages||9|
|Journal||Nuova Rivista di Neurologia|
|Publication status||Published - Jan 2003|
ASJC Scopus subject areas
- Clinical Neurology