Behavioural data on dermorphins in mice

Stefano Puglisi-Allegra, Claudio Castellano, Umberto Filibeck, Alberto Oliverio, Pietro Melchiorri

Research output: Contribution to journalArticlepeer-review

Abstract

Dermorphin, an opioid peptide occuring in amphibian skin, exerted a depressive effect on locomotor activity of C57B1/6 mice and an analgesic effect when injected intravenously. Intracerebroventricular injections of dermorphin enhanced locomotor activity and resulted in analgesia. A stimulating effect of intracerebroventricular administration on locomotor activity was also induced by shorter homologues of dermorphin and [D-Ala2, Leu5]enkephalinamide, while β-endorphin produced a depression. It is suggested that dermorphin acts on central receptor populations activated by morphine and enkephalins.

Original languageEnglish
Pages (from-to)223-227
Number of pages5
JournalEuropean Journal of Pharmacology
Volume82
Issue number3-4
DOIs
Publication statusPublished - Aug 27 1982

Keywords

  • Analgesia
  • Dermorphin
  • Endogenous opioids
  • Locomotor activity
  • Mice

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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