TY - JOUR
T1 - Behavioural data on dermorphins in mice
AU - Puglisi-Allegra, Stefano
AU - Castellano, Claudio
AU - Filibeck, Umberto
AU - Oliverio, Alberto
AU - Melchiorri, Pietro
PY - 1982/8/27
Y1 - 1982/8/27
N2 - Dermorphin, an opioid peptide occuring in amphibian skin, exerted a depressive effect on locomotor activity of C57B1/6 mice and an analgesic effect when injected intravenously. Intracerebroventricular injections of dermorphin enhanced locomotor activity and resulted in analgesia. A stimulating effect of intracerebroventricular administration on locomotor activity was also induced by shorter homologues of dermorphin and [D-Ala2, Leu5]enkephalinamide, while β-endorphin produced a depression. It is suggested that dermorphin acts on central receptor populations activated by morphine and enkephalins.
AB - Dermorphin, an opioid peptide occuring in amphibian skin, exerted a depressive effect on locomotor activity of C57B1/6 mice and an analgesic effect when injected intravenously. Intracerebroventricular injections of dermorphin enhanced locomotor activity and resulted in analgesia. A stimulating effect of intracerebroventricular administration on locomotor activity was also induced by shorter homologues of dermorphin and [D-Ala2, Leu5]enkephalinamide, while β-endorphin produced a depression. It is suggested that dermorphin acts on central receptor populations activated by morphine and enkephalins.
KW - Analgesia
KW - Dermorphin
KW - Endogenous opioids
KW - Locomotor activity
KW - Mice
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U2 - 10.1016/0014-2999(82)90518-0
DO - 10.1016/0014-2999(82)90518-0
M3 - Article
C2 - 7128688
AN - SCOPUS:0019967278
VL - 82
SP - 223
EP - 227
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 3-4
ER -