Behind the scenes: Endo/exocytosis in the acquisition of metastatic traits

Research output: Contribution to journalReview articlepeer-review

Abstract

Alterations of endo/exocytic proteins have long been associated with malignant transformation, and genes encoding membrane trafficking proteins have been identified as bona fide drivers of tumorigenesis. Focusing on the mechanisms underlying the impact of endo/exocytic proteins in cancer, a scenario emerges in which altered trafficking routes/networks appear to be preferentially involved in the acquisition of prometastatic traits. This involvement in metastasis frequently occurs through the integration of programs leading to migratory/invasive phenotypes, survival and resistance to environmental stresses, epithelial-to-mesenchymal transition, and the emergence of cancer stem cells. These findings might have important implications in the clinical setting for the development of metastasis-specific drugs and for patient stratification to optimize the use of available therapies.

Original languageEnglish
Pages (from-to)1813-1817
Number of pages5
JournalCancer Research
Volume77
Issue number8
DOIs
Publication statusPublished - Apr 15 2017

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Behind the scenes: Endo/exocytosis in the acquisition of metastatic traits'. Together they form a unique fingerprint.

Cite this