BEL-2, an extended-spectrum β-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa

Laurent Poirel, Jean Denis Docquier, Filomena De Luca, Annemie Verlinde, Louis Ide, Gian Maria Rossolini, Patrice Nordmann

Research output: Contribution to journalArticlepeer-review

Abstract

A Pseudomonas aeruginosa isolate recovered in Belgium produced a novel extended-spectrum ß-lactamase, BEL-2, differing from BEL-1 by a single Leu162Phe substitution. That modification significantly altered the kinetic properties of the enzyme, increasing its affinity for expanded-spectrum cephalosporins. The blaBEL-2 gene was identified from a P. aeruginosa isolate clonally related to another blaBEL-1-positive isolate.

Original languageEnglish
Pages (from-to)533-535
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume54
Issue number1
DOIs
Publication statusPublished - Jan 2010

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

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