BEL-2, an extended-spectrum β-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa

Laurent Poirel, Jean Denis Docquier, Filomena De Luca, Annemie Verlinde, Louis Ide, Gian Maria Rossolini, Patrice Nordmann

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A Pseudomonas aeruginosa isolate recovered in Belgium produced a novel extended-spectrum ß-lactamase, BEL-2, differing from BEL-1 by a single Leu162Phe substitution. That modification significantly altered the kinetic properties of the enzyme, increasing its affinity for expanded-spectrum cephalosporins. The blaBEL-2 gene was identified from a P. aeruginosa isolate clonally related to another blaBEL-1-positive isolate.

Original languageEnglish
Pages (from-to)533-535
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume54
Issue number1
DOIs
Publication statusPublished - Jan 2010

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Cephalosporins
Pseudomonas aeruginosa
Belgium
Enzymes
Genes

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

BEL-2, an extended-spectrum β-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. / Poirel, Laurent; Docquier, Jean Denis; De Luca, Filomena; Verlinde, Annemie; Ide, Louis; Rossolini, Gian Maria; Nordmann, Patrice.

In: Antimicrobial Agents and Chemotherapy, Vol. 54, No. 1, 01.2010, p. 533-535.

Research output: Contribution to journalArticle

Poirel, Laurent ; Docquier, Jean Denis ; De Luca, Filomena ; Verlinde, Annemie ; Ide, Louis ; Rossolini, Gian Maria ; Nordmann, Patrice. / BEL-2, an extended-spectrum β-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa. In: Antimicrobial Agents and Chemotherapy. 2010 ; Vol. 54, No. 1. pp. 533-535.
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