Below Safety Limits, Every Unit of Glomerular Filtration Rate Counts: Assessing the Relationship Between Renal Function and Cancer-specific Mortality in Renal Cell Carcinoma

Alessandro Antonelli, Andrea Minervini, Marco Sandri, Roberto Bertini, Riccardo Bertolo, Marco Carini, Maria Furlan, Alessandro Larcher, Guglielmo Mantica, Andrea Mari, Francesco Montorsi, Carlotta Palumbo, Francesco Porpiglia, Paola Romagnani, Claudio Simeone, Carlo Terrone, Umberto Capitanio

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: The hypothesis that renal function could influence oncological outcomes is supported by anecdotal literature. Objective: To determine whether estimated glomerular filtration rate (eGFR) is related to cancer-specific mortality (CSM) in patients who had undergone surgery for renal cell carcinoma (RCC). Design, setting, and participants: A retrospective analysis of 3457 patients who underwent radical (39%) or partial nephrectomy (61%) for cT1–2 RCC between 1990 and 2015. Outcome measurements and statistical analysis: The eGFR was calculated by the Chronic Kidney Disease Epidemiology Collaboration equation. CSM was analyzed in a multivariable competing-risk framework, estimating the subdistribution hazard ratio (SHR) accounting for deaths from other causes. The relationship between eGFR and CSM was investigated from multiple statistical approaches—extended Cox regression with eGFR incorporated as a time-dependent covariate, landmark analysis, and joint modeling. Other predictors were selected by competing-risk random forest method and backward elimination. Results and limitations: The relationship between eGFR and CSM was graphically described by a linear spline, i.e. a continuous piecewise linear function with two lines joined by a knot. For eGFR treated as a time-dependent covariate, the knot was located at 65 ml/min; at landmark analysis with eGFR at the baseline, 12 mo, and last functional follow-up, the knots were 85, 60, and 65 ml/min, respectively. In multivariable competing-risk analysis, CSM was associated with eGFR only for values of eGFR below these cutoffs, with SHRs for every 10 ml/min of reduction in eGFR of 1.25 (p = 0.003), 1.16 (p = 0.028), 1.44 (p = 0.02), and 1.16 (p = 0.042), corresponding to time-dependent eGFR, and eGFR at baseline, 12 mo, and last functional follow-up, respectively. Joint modeling confirmed these results. A retrospective design with inherent biases in data collection represents a limitation. Conclusions: In patients undergoing surgery for RCC, renal function should be preserved in order to improve cancer-related survival. Patient summary: The relationship between renal function and probability of dying due to renal cancer is complex. The present study found a correlation between glomerular filtration rate and cancer specific mortality that could reconsider the oncological role of renal function in patients undergoing surgery for renal cancer. We investigate the correlation between preserved renal function during surgery and cancer-specific survival for renal cancer. Analyzing 3457 patients submitted to surgery, we found a linear and inverse correlation between estimated glomerular filtration rate (eGFR) and cancer-related mortality only for values of eGFR below certain limits.

Original languageEnglish
Pages (from-to)661-667
JournalEuropean Urology
Volume74
Issue number5
DOIs
Publication statusPublished - 2018

Fingerprint

Kidney Neoplasms
Glomerular Filtration Rate
Renal Cell Carcinoma
Safety
Mortality
Neoplasms
Kidney
Joints
Survival
Nephrectomy
Chronic Renal Insufficiency

Keywords

  • Cancer-specific mortality
  • Estimated glomerular filtration rate
  • Partial nephrectomy
  • Prognosis
  • Radical nephrectomy
  • Renal cell carcinoma
  • Renal function

ASJC Scopus subject areas

  • Urology

Cite this

Below Safety Limits, Every Unit of Glomerular Filtration Rate Counts : Assessing the Relationship Between Renal Function and Cancer-specific Mortality in Renal Cell Carcinoma. / Antonelli, Alessandro; Minervini, Andrea; Sandri, Marco; Bertini, Roberto; Bertolo, Riccardo; Carini, Marco; Furlan, Maria; Larcher, Alessandro; Mantica, Guglielmo; Mari, Andrea; Montorsi, Francesco; Palumbo, Carlotta; Porpiglia, Francesco; Romagnani, Paola; Simeone, Claudio; Terrone, Carlo; Capitanio, Umberto.

In: European Urology, Vol. 74, No. 5, 2018, p. 661-667.

Research output: Contribution to journalArticle

Antonelli, A, Minervini, A, Sandri, M, Bertini, R, Bertolo, R, Carini, M, Furlan, M, Larcher, A, Mantica, G, Mari, A, Montorsi, F, Palumbo, C, Porpiglia, F, Romagnani, P, Simeone, C, Terrone, C & Capitanio, U 2018, 'Below Safety Limits, Every Unit of Glomerular Filtration Rate Counts: Assessing the Relationship Between Renal Function and Cancer-specific Mortality in Renal Cell Carcinoma', European Urology, vol. 74, no. 5, pp. 661-667. https://doi.org/10.1016/j.eururo.2018.07.029
Antonelli, Alessandro ; Minervini, Andrea ; Sandri, Marco ; Bertini, Roberto ; Bertolo, Riccardo ; Carini, Marco ; Furlan, Maria ; Larcher, Alessandro ; Mantica, Guglielmo ; Mari, Andrea ; Montorsi, Francesco ; Palumbo, Carlotta ; Porpiglia, Francesco ; Romagnani, Paola ; Simeone, Claudio ; Terrone, Carlo ; Capitanio, Umberto. / Below Safety Limits, Every Unit of Glomerular Filtration Rate Counts : Assessing the Relationship Between Renal Function and Cancer-specific Mortality in Renal Cell Carcinoma. In: European Urology. 2018 ; Vol. 74, No. 5. pp. 661-667.
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abstract = "Background: The hypothesis that renal function could influence oncological outcomes is supported by anecdotal literature. Objective: To determine whether estimated glomerular filtration rate (eGFR) is related to cancer-specific mortality (CSM) in patients who had undergone surgery for renal cell carcinoma (RCC). Design, setting, and participants: A retrospective analysis of 3457 patients who underwent radical (39{\%}) or partial nephrectomy (61{\%}) for cT1–2 RCC between 1990 and 2015. Outcome measurements and statistical analysis: The eGFR was calculated by the Chronic Kidney Disease Epidemiology Collaboration equation. CSM was analyzed in a multivariable competing-risk framework, estimating the subdistribution hazard ratio (SHR) accounting for deaths from other causes. The relationship between eGFR and CSM was investigated from multiple statistical approaches—extended Cox regression with eGFR incorporated as a time-dependent covariate, landmark analysis, and joint modeling. Other predictors were selected by competing-risk random forest method and backward elimination. Results and limitations: The relationship between eGFR and CSM was graphically described by a linear spline, i.e. a continuous piecewise linear function with two lines joined by a knot. For eGFR treated as a time-dependent covariate, the knot was located at 65 ml/min; at landmark analysis with eGFR at the baseline, 12 mo, and last functional follow-up, the knots were 85, 60, and 65 ml/min, respectively. In multivariable competing-risk analysis, CSM was associated with eGFR only for values of eGFR below these cutoffs, with SHRs for every 10 ml/min of reduction in eGFR of 1.25 (p = 0.003), 1.16 (p = 0.028), 1.44 (p = 0.02), and 1.16 (p = 0.042), corresponding to time-dependent eGFR, and eGFR at baseline, 12 mo, and last functional follow-up, respectively. Joint modeling confirmed these results. A retrospective design with inherent biases in data collection represents a limitation. Conclusions: In patients undergoing surgery for RCC, renal function should be preserved in order to improve cancer-related survival. Patient summary: The relationship between renal function and probability of dying due to renal cancer is complex. The present study found a correlation between glomerular filtration rate and cancer specific mortality that could reconsider the oncological role of renal function in patients undergoing surgery for renal cancer. We investigate the correlation between preserved renal function during surgery and cancer-specific survival for renal cancer. Analyzing 3457 patients submitted to surgery, we found a linear and inverse correlation between estimated glomerular filtration rate (eGFR) and cancer-related mortality only for values of eGFR below certain limits.",
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TY - JOUR

T1 - Below Safety Limits, Every Unit of Glomerular Filtration Rate Counts

T2 - Assessing the Relationship Between Renal Function and Cancer-specific Mortality in Renal Cell Carcinoma

AU - Antonelli, Alessandro

AU - Minervini, Andrea

AU - Sandri, Marco

AU - Bertini, Roberto

AU - Bertolo, Riccardo

AU - Carini, Marco

AU - Furlan, Maria

AU - Larcher, Alessandro

AU - Mantica, Guglielmo

AU - Mari, Andrea

AU - Montorsi, Francesco

AU - Palumbo, Carlotta

AU - Porpiglia, Francesco

AU - Romagnani, Paola

AU - Simeone, Claudio

AU - Terrone, Carlo

AU - Capitanio, Umberto

PY - 2018

Y1 - 2018

N2 - Background: The hypothesis that renal function could influence oncological outcomes is supported by anecdotal literature. Objective: To determine whether estimated glomerular filtration rate (eGFR) is related to cancer-specific mortality (CSM) in patients who had undergone surgery for renal cell carcinoma (RCC). Design, setting, and participants: A retrospective analysis of 3457 patients who underwent radical (39%) or partial nephrectomy (61%) for cT1–2 RCC between 1990 and 2015. Outcome measurements and statistical analysis: The eGFR was calculated by the Chronic Kidney Disease Epidemiology Collaboration equation. CSM was analyzed in a multivariable competing-risk framework, estimating the subdistribution hazard ratio (SHR) accounting for deaths from other causes. The relationship between eGFR and CSM was investigated from multiple statistical approaches—extended Cox regression with eGFR incorporated as a time-dependent covariate, landmark analysis, and joint modeling. Other predictors were selected by competing-risk random forest method and backward elimination. Results and limitations: The relationship between eGFR and CSM was graphically described by a linear spline, i.e. a continuous piecewise linear function with two lines joined by a knot. For eGFR treated as a time-dependent covariate, the knot was located at 65 ml/min; at landmark analysis with eGFR at the baseline, 12 mo, and last functional follow-up, the knots were 85, 60, and 65 ml/min, respectively. In multivariable competing-risk analysis, CSM was associated with eGFR only for values of eGFR below these cutoffs, with SHRs for every 10 ml/min of reduction in eGFR of 1.25 (p = 0.003), 1.16 (p = 0.028), 1.44 (p = 0.02), and 1.16 (p = 0.042), corresponding to time-dependent eGFR, and eGFR at baseline, 12 mo, and last functional follow-up, respectively. Joint modeling confirmed these results. A retrospective design with inherent biases in data collection represents a limitation. Conclusions: In patients undergoing surgery for RCC, renal function should be preserved in order to improve cancer-related survival. Patient summary: The relationship between renal function and probability of dying due to renal cancer is complex. The present study found a correlation between glomerular filtration rate and cancer specific mortality that could reconsider the oncological role of renal function in patients undergoing surgery for renal cancer. We investigate the correlation between preserved renal function during surgery and cancer-specific survival for renal cancer. Analyzing 3457 patients submitted to surgery, we found a linear and inverse correlation between estimated glomerular filtration rate (eGFR) and cancer-related mortality only for values of eGFR below certain limits.

AB - Background: The hypothesis that renal function could influence oncological outcomes is supported by anecdotal literature. Objective: To determine whether estimated glomerular filtration rate (eGFR) is related to cancer-specific mortality (CSM) in patients who had undergone surgery for renal cell carcinoma (RCC). Design, setting, and participants: A retrospective analysis of 3457 patients who underwent radical (39%) or partial nephrectomy (61%) for cT1–2 RCC between 1990 and 2015. Outcome measurements and statistical analysis: The eGFR was calculated by the Chronic Kidney Disease Epidemiology Collaboration equation. CSM was analyzed in a multivariable competing-risk framework, estimating the subdistribution hazard ratio (SHR) accounting for deaths from other causes. The relationship between eGFR and CSM was investigated from multiple statistical approaches—extended Cox regression with eGFR incorporated as a time-dependent covariate, landmark analysis, and joint modeling. Other predictors were selected by competing-risk random forest method and backward elimination. Results and limitations: The relationship between eGFR and CSM was graphically described by a linear spline, i.e. a continuous piecewise linear function with two lines joined by a knot. For eGFR treated as a time-dependent covariate, the knot was located at 65 ml/min; at landmark analysis with eGFR at the baseline, 12 mo, and last functional follow-up, the knots were 85, 60, and 65 ml/min, respectively. In multivariable competing-risk analysis, CSM was associated with eGFR only for values of eGFR below these cutoffs, with SHRs for every 10 ml/min of reduction in eGFR of 1.25 (p = 0.003), 1.16 (p = 0.028), 1.44 (p = 0.02), and 1.16 (p = 0.042), corresponding to time-dependent eGFR, and eGFR at baseline, 12 mo, and last functional follow-up, respectively. Joint modeling confirmed these results. A retrospective design with inherent biases in data collection represents a limitation. Conclusions: In patients undergoing surgery for RCC, renal function should be preserved in order to improve cancer-related survival. Patient summary: The relationship between renal function and probability of dying due to renal cancer is complex. The present study found a correlation between glomerular filtration rate and cancer specific mortality that could reconsider the oncological role of renal function in patients undergoing surgery for renal cancer. We investigate the correlation between preserved renal function during surgery and cancer-specific survival for renal cancer. Analyzing 3457 patients submitted to surgery, we found a linear and inverse correlation between estimated glomerular filtration rate (eGFR) and cancer-related mortality only for values of eGFR below certain limits.

KW - Cancer-specific mortality

KW - Estimated glomerular filtration rate

KW - Partial nephrectomy

KW - Prognosis

KW - Radical nephrectomy

KW - Renal cell carcinoma

KW - Renal function

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