Below Safety Limits, Every Unit of Glomerular Filtration Rate Counts: Assessing the Relationship Between Renal Function and Cancer-specific Mortality in Renal Cell Carcinoma

A Antonelli, A Minervini, M Sandri, R Bertini, R Bertolo, M Carini, M Furlan, A Larcher, G Mantica, A Mari, F Montorsi, C Palumbo, F Porpiglia, P Romagnani, C Simeone, C Terrone, U Capitanio

Research output: Contribution to journalArticle

Abstract

Background: The hypothesis that renal function could influence oncological outcomes is supported by anecdotal literature. Objective: To determine whether estimated glomerular filtration rate (eGFR) is related to cancer-specific mortality (CSM) in patients who had undergone surgery for renal cell carcinoma (RCC). Design, setting, and participants: A retrospective analysis of 3457 patients who underwent radical (39%) or partial nephrectomy (61%) for cT1–2 RCC between 1990 and 2015. Outcome measurements and statistical analysis: The eGFR was calculated by the Chronic Kidney Disease Epidemiology Collaboration equation. CSM was analyzed in a multivariable competing-risk framework, estimating the subdistribution hazard ratio (SHR) accounting for deaths from other causes. The relationship between eGFR and CSM was investigated from multiple statistical approaches—extended Cox regression with eGFR incorporated as a time-dependent covariate, landmark analysis, and joint modeling. Other predictors were selected by competing-risk random forest method and backward elimination. Results and limitations: The relationship between eGFR and CSM was graphically described by a linear spline, i.e. a continuous piecewise linear function with two lines joined by a knot. For eGFR treated as a time-dependent covariate, the knot was located at 65 ml/min; at landmark analysis with eGFR at the baseline, 12 mo, and last functional follow-up, the knots were 85, 60, and 65 ml/min, respectively. In multivariable competing-risk analysis, CSM was associated with eGFR only for values of eGFR below these cutoffs, with SHRs for every 10 ml/min of reduction in eGFR of 1.25 (p = 0.003), 1.16 (p = 0.028), 1.44 (p = 0.02), and 1.16 (p = 0.042), corresponding to time-dependent eGFR, and eGFR at baseline, 12 mo, and last functional follow-up, respectively. Joint modeling confirmed these results. A retrospective design with inherent biases in data collection represents a limitation. Conclusions: In patients undergoing surgery for RCC, renal function should be preserved in order to improve cancer-related survival. Patient summary: The relationship between renal function and probability of dying due to renal cancer is complex. The present study found a correlation between glomerular filtration rate and cancer specific mortality that could reconsider the oncological role of renal function in patients undergoing surgery for renal cancer. We investigate the correlation between preserved renal function during surgery and cancer-specific survival for renal cancer. Analyzing 3457 patients submitted to surgery, we found a linear and inverse correlation between estimated glomerular filtration rate (eGFR) and cancer-related mortality only for values of eGFR below certain limits. © 2018 European Association of Urology
Original languageEnglish
Pages (from-to)661-667
Number of pages7
JournalEuropean Urology
Volume74
Issue number5
DOIs
Publication statusPublished - 2018

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Kidney Neoplasms
Glomerular Filtration Rate
Renal Cell Carcinoma
Safety
Mortality
Neoplasms
Kidney
Joints
Survival
Nephrectomy
Chronic Renal Insufficiency

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Below Safety Limits, Every Unit of Glomerular Filtration Rate Counts: Assessing the Relationship Between Renal Function and Cancer-specific Mortality in Renal Cell Carcinoma. / Antonelli, A; Minervini, A; Sandri, M; Bertini, R; Bertolo, R; Carini, M; Furlan, M; Larcher, A; Mantica, G; Mari, A; Montorsi, F; Palumbo, C; Porpiglia, F; Romagnani, P; Simeone, C; Terrone, C; Capitanio, U.

In: European Urology, Vol. 74, No. 5, 2018, p. 661-667.

Research output: Contribution to journalArticle

Antonelli, A, Minervini, A, Sandri, M, Bertini, R, Bertolo, R, Carini, M, Furlan, M, Larcher, A, Mantica, G, Mari, A, Montorsi, F, Palumbo, C, Porpiglia, F, Romagnani, P, Simeone, C, Terrone, C & Capitanio, U 2018, 'Below Safety Limits, Every Unit of Glomerular Filtration Rate Counts: Assessing the Relationship Between Renal Function and Cancer-specific Mortality in Renal Cell Carcinoma', European Urology, vol. 74, no. 5, pp. 661-667. https://doi.org/10.1016/j.eururo.2018.07.029
Antonelli, A ; Minervini, A ; Sandri, M ; Bertini, R ; Bertolo, R ; Carini, M ; Furlan, M ; Larcher, A ; Mantica, G ; Mari, A ; Montorsi, F ; Palumbo, C ; Porpiglia, F ; Romagnani, P ; Simeone, C ; Terrone, C ; Capitanio, U. / Below Safety Limits, Every Unit of Glomerular Filtration Rate Counts: Assessing the Relationship Between Renal Function and Cancer-specific Mortality in Renal Cell Carcinoma. In: European Urology. 2018 ; Vol. 74, No. 5. pp. 661-667.
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abstract = "Background: The hypothesis that renal function could influence oncological outcomes is supported by anecdotal literature. Objective: To determine whether estimated glomerular filtration rate (eGFR) is related to cancer-specific mortality (CSM) in patients who had undergone surgery for renal cell carcinoma (RCC). Design, setting, and participants: A retrospective analysis of 3457 patients who underwent radical (39{\%}) or partial nephrectomy (61{\%}) for cT1–2 RCC between 1990 and 2015. Outcome measurements and statistical analysis: The eGFR was calculated by the Chronic Kidney Disease Epidemiology Collaboration equation. CSM was analyzed in a multivariable competing-risk framework, estimating the subdistribution hazard ratio (SHR) accounting for deaths from other causes. The relationship between eGFR and CSM was investigated from multiple statistical approaches—extended Cox regression with eGFR incorporated as a time-dependent covariate, landmark analysis, and joint modeling. Other predictors were selected by competing-risk random forest method and backward elimination. Results and limitations: The relationship between eGFR and CSM was graphically described by a linear spline, i.e. a continuous piecewise linear function with two lines joined by a knot. For eGFR treated as a time-dependent covariate, the knot was located at 65 ml/min; at landmark analysis with eGFR at the baseline, 12 mo, and last functional follow-up, the knots were 85, 60, and 65 ml/min, respectively. In multivariable competing-risk analysis, CSM was associated with eGFR only for values of eGFR below these cutoffs, with SHRs for every 10 ml/min of reduction in eGFR of 1.25 (p = 0.003), 1.16 (p = 0.028), 1.44 (p = 0.02), and 1.16 (p = 0.042), corresponding to time-dependent eGFR, and eGFR at baseline, 12 mo, and last functional follow-up, respectively. Joint modeling confirmed these results. A retrospective design with inherent biases in data collection represents a limitation. Conclusions: In patients undergoing surgery for RCC, renal function should be preserved in order to improve cancer-related survival. Patient summary: The relationship between renal function and probability of dying due to renal cancer is complex. The present study found a correlation between glomerular filtration rate and cancer specific mortality that could reconsider the oncological role of renal function in patients undergoing surgery for renal cancer. We investigate the correlation between preserved renal function during surgery and cancer-specific survival for renal cancer. Analyzing 3457 patients submitted to surgery, we found a linear and inverse correlation between estimated glomerular filtration rate (eGFR) and cancer-related mortality only for values of eGFR below certain limits. {\circledC} 2018 European Association of Urology",
author = "A Antonelli and A Minervini and M Sandri and R Bertini and R Bertolo and M Carini and M Furlan and A Larcher and G Mantica and A Mari and F Montorsi and C Palumbo and F Porpiglia and P Romagnani and C Simeone and C Terrone and U Capitanio",
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T1 - Below Safety Limits, Every Unit of Glomerular Filtration Rate Counts: Assessing the Relationship Between Renal Function and Cancer-specific Mortality in Renal Cell Carcinoma

AU - Antonelli, A

AU - Minervini, A

AU - Sandri, M

AU - Bertini, R

AU - Bertolo, R

AU - Carini, M

AU - Furlan, M

AU - Larcher, A

AU - Mantica, G

AU - Mari, A

AU - Montorsi, F

AU - Palumbo, C

AU - Porpiglia, F

AU - Romagnani, P

AU - Simeone, C

AU - Terrone, C

AU - Capitanio, U

PY - 2018

Y1 - 2018

N2 - Background: The hypothesis that renal function could influence oncological outcomes is supported by anecdotal literature. Objective: To determine whether estimated glomerular filtration rate (eGFR) is related to cancer-specific mortality (CSM) in patients who had undergone surgery for renal cell carcinoma (RCC). Design, setting, and participants: A retrospective analysis of 3457 patients who underwent radical (39%) or partial nephrectomy (61%) for cT1–2 RCC between 1990 and 2015. Outcome measurements and statistical analysis: The eGFR was calculated by the Chronic Kidney Disease Epidemiology Collaboration equation. CSM was analyzed in a multivariable competing-risk framework, estimating the subdistribution hazard ratio (SHR) accounting for deaths from other causes. The relationship between eGFR and CSM was investigated from multiple statistical approaches—extended Cox regression with eGFR incorporated as a time-dependent covariate, landmark analysis, and joint modeling. Other predictors were selected by competing-risk random forest method and backward elimination. Results and limitations: The relationship between eGFR and CSM was graphically described by a linear spline, i.e. a continuous piecewise linear function with two lines joined by a knot. For eGFR treated as a time-dependent covariate, the knot was located at 65 ml/min; at landmark analysis with eGFR at the baseline, 12 mo, and last functional follow-up, the knots were 85, 60, and 65 ml/min, respectively. In multivariable competing-risk analysis, CSM was associated with eGFR only for values of eGFR below these cutoffs, with SHRs for every 10 ml/min of reduction in eGFR of 1.25 (p = 0.003), 1.16 (p = 0.028), 1.44 (p = 0.02), and 1.16 (p = 0.042), corresponding to time-dependent eGFR, and eGFR at baseline, 12 mo, and last functional follow-up, respectively. Joint modeling confirmed these results. A retrospective design with inherent biases in data collection represents a limitation. Conclusions: In patients undergoing surgery for RCC, renal function should be preserved in order to improve cancer-related survival. Patient summary: The relationship between renal function and probability of dying due to renal cancer is complex. The present study found a correlation between glomerular filtration rate and cancer specific mortality that could reconsider the oncological role of renal function in patients undergoing surgery for renal cancer. We investigate the correlation between preserved renal function during surgery and cancer-specific survival for renal cancer. Analyzing 3457 patients submitted to surgery, we found a linear and inverse correlation between estimated glomerular filtration rate (eGFR) and cancer-related mortality only for values of eGFR below certain limits. © 2018 European Association of Urology

AB - Background: The hypothesis that renal function could influence oncological outcomes is supported by anecdotal literature. Objective: To determine whether estimated glomerular filtration rate (eGFR) is related to cancer-specific mortality (CSM) in patients who had undergone surgery for renal cell carcinoma (RCC). Design, setting, and participants: A retrospective analysis of 3457 patients who underwent radical (39%) or partial nephrectomy (61%) for cT1–2 RCC between 1990 and 2015. Outcome measurements and statistical analysis: The eGFR was calculated by the Chronic Kidney Disease Epidemiology Collaboration equation. CSM was analyzed in a multivariable competing-risk framework, estimating the subdistribution hazard ratio (SHR) accounting for deaths from other causes. The relationship between eGFR and CSM was investigated from multiple statistical approaches—extended Cox regression with eGFR incorporated as a time-dependent covariate, landmark analysis, and joint modeling. Other predictors were selected by competing-risk random forest method and backward elimination. Results and limitations: The relationship between eGFR and CSM was graphically described by a linear spline, i.e. a continuous piecewise linear function with two lines joined by a knot. For eGFR treated as a time-dependent covariate, the knot was located at 65 ml/min; at landmark analysis with eGFR at the baseline, 12 mo, and last functional follow-up, the knots were 85, 60, and 65 ml/min, respectively. In multivariable competing-risk analysis, CSM was associated with eGFR only for values of eGFR below these cutoffs, with SHRs for every 10 ml/min of reduction in eGFR of 1.25 (p = 0.003), 1.16 (p = 0.028), 1.44 (p = 0.02), and 1.16 (p = 0.042), corresponding to time-dependent eGFR, and eGFR at baseline, 12 mo, and last functional follow-up, respectively. Joint modeling confirmed these results. A retrospective design with inherent biases in data collection represents a limitation. Conclusions: In patients undergoing surgery for RCC, renal function should be preserved in order to improve cancer-related survival. Patient summary: The relationship between renal function and probability of dying due to renal cancer is complex. The present study found a correlation between glomerular filtration rate and cancer specific mortality that could reconsider the oncological role of renal function in patients undergoing surgery for renal cancer. We investigate the correlation between preserved renal function during surgery and cancer-specific survival for renal cancer. Analyzing 3457 patients submitted to surgery, we found a linear and inverse correlation between estimated glomerular filtration rate (eGFR) and cancer-related mortality only for values of eGFR below certain limits. © 2018 European Association of Urology

U2 - 10.1016/j.eururo.2018.07.029

DO - 10.1016/j.eururo.2018.07.029

M3 - Article

VL - 74

SP - 661

EP - 667

JO - European Urology

JF - European Urology

SN - 0302-2838

IS - 5

ER -