Beneficial autoimmunity in Type 1 diabetes mellitus

Ehud Hauben, Maria Grazia Roncarolo, Uri Nevo, Michal Schwartz

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The trigger that leads to the pathogenesis of type 1 diabetes is currently unknown. It is well established that the pathophysiology of the disease is biphasic. In the first stage, leukocytes infiltrate the pancreatic islets in a response that does not cause damage. In the second phase, which occurs only in diabetes-prone individuals and strains, autoreactive T cells acquire aggressive potential and destroy the majority of the pancreatic islets. Rodents and humans exhibit a physiological ripple of apoptotic β-cell death shortly after birth, which induces an adaptive autoimmune response towards islet-antigens, both in diabetes-prone non-obese diabetic (NOD) mice and in mice that do not develop diabetes. Here, we propose that the early T cell-mediated autoimmune response towards islet-antigens is physiological, purposeful and beneficial.

Original languageEnglish
Pages (from-to)248-253
Number of pages6
JournalTrends in Immunology
Volume26
Issue number5
DOIs
Publication statusPublished - May 2005

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Autoimmunity
Type 1 Diabetes Mellitus
Islets of Langerhans
T-Lymphocytes
Antigens
Inbred NOD Mouse
Rodentia
Leukocytes
Cell Death
Parturition

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Hauben, E., Roncarolo, M. G., Nevo, U., & Schwartz, M. (2005). Beneficial autoimmunity in Type 1 diabetes mellitus. Trends in Immunology, 26(5), 248-253. https://doi.org/10.1016/j.it.2005.03.004

Beneficial autoimmunity in Type 1 diabetes mellitus. / Hauben, Ehud; Roncarolo, Maria Grazia; Nevo, Uri; Schwartz, Michal.

In: Trends in Immunology, Vol. 26, No. 5, 05.2005, p. 248-253.

Research output: Contribution to journalArticle

Hauben, E, Roncarolo, MG, Nevo, U & Schwartz, M 2005, 'Beneficial autoimmunity in Type 1 diabetes mellitus', Trends in Immunology, vol. 26, no. 5, pp. 248-253. https://doi.org/10.1016/j.it.2005.03.004
Hauben, Ehud ; Roncarolo, Maria Grazia ; Nevo, Uri ; Schwartz, Michal. / Beneficial autoimmunity in Type 1 diabetes mellitus. In: Trends in Immunology. 2005 ; Vol. 26, No. 5. pp. 248-253.
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