Beneficial effect of oestrogen on exercise-induced myocardial ischaemia in women with coronary artery disease

G. M C Rosano, P. M. Sarrel, P. A. Poole-Wilson, P. Collins

Research output: Contribution to journalArticle

Abstract

Oestradiol-17β causes relaxation of isolated coronary arteries and increases blood flow in several vascular beds in human beings and animals. Oestrogen replacement therapy is associated with a lower incidence of cardiovascular disease, but the acute effects of Oestradiol-17β on myocardial ischaemia are unknown. We have studied the acute effect of sublingual oestradiol-17β on exercise-induced myocardial ischaemia in eleven women (mean age 58 [SD 8] years) with coronary artery disease. The women did two treadmill exercise tests on separate days; 40 min before the test they took sublingual oestradiol-17β (1 mg) or placebo, in random order. Plasma Oestradiol-17β concentrations were confirmed to be higher after sublingual oestradiol-17β than after placebo (2531 [1192] vs 155 [168] pmol/L, p

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalLancet
Volume342
Issue number8864
DOIs
Publication statusPublished - Jul 17 1993

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ASJC Scopus subject areas

  • Medicine(all)

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