Beneficial effects of adaptive servo-ventilation on natriuretic peptides and diastolic function in acute heart failure patients with preserved ejection fraction and sleep-disordered breathing

E D'Elia, P Ferrero, C Vittori, A Iacovoni, A Grosu, M Gori, V Duino, S Perlini, Michele Senni

Research output: Contribution to journalArticle


PURPOSE: Adaptive servo-ventilation (ASV) is a ventilator algorithm able to correct breathing through anticyclic support of breathing in patients with central sleep apnea (CSA). So far, very few data exist regarding the role of ASV on acute heart failure with preserved ejection fraction (HFpEF). METHODS: We performed a single-center prospective, randomized, case-control study in consecutive acute HFpEF (left ventricle ejection fraction, LVEF ≥ 45%) patients with sleep-disordered breathing (SDB, apnea-hypopnea index, AHI > 15/h) and prevalence of CSA. RESULTS: We included ten consecutive patients randomized for ASV on top of standard therapy for acute heart failure (group 1) versus standard care alone (group 2). ASV therapy significantly reduced AHI and CSA. An improvement in cardiac diastolic function was seen in group 1 compared to group 2 (E/E' 17.5 to 9.6, p 
Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalSleep and Breathing
Issue number1
Publication statusPublished - Mar 2019



  • Adaptive servo-ventilation
  • Central sleep apnea
  • Diastolic function
  • Heart failure with preserved ejection fraction
  • Right ventricle
  • Acute Disease
  • Aged
  • Case-Control Studies
  • Comorbidity
  • Continuous Positive Airway Pressure/*methods
  • Diastole/*physiology
  • Echocardiography
  • Female
  • Heart Failure/physiopathology/*therapy
  • Humans
  • Male
  • Middle Aged
  • Natriuretic Peptide, Brain/*blood
  • Prospective Studies
  • Sleep Apnea Syndromes/physiopathology/*therapy
  • Sleep Apnea, Central/physiopathology/*therapy
  • Stroke Volume/*physiology
  • Ventricular Function, Right/physiology

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