Beneficial effects of adaptive servo-ventilation on natriuretic peptides and diastolic function in acute heart failure patients with preserved ejection fraction and sleep-disordered breathing

E D'Elia; P Ferrero; C Vittori; A Iacovoni; A Grosu; M Gori; V Duino; S Perlini; Michele Senni

doi:10.1007/s11325-018-1681-z

Beneficial effects of adaptive servo-ventilation on natriuretic peptides and diastolic function in acute heart failure patients with preserved ejection fraction and sleep-disordered breathing

E D'Elia, P Ferrero, C Vittori, A Iacovoni, A Grosu, M Gori, V Duino, S Perlini, Michele Senni

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE: Adaptive servo-ventilation (ASV) is a ventilator algorithm able to correct breathing through anticyclic support of breathing in patients with central sleep apnea (CSA). So far, very few data exist regarding the role of ASV on acute heart failure with preserved ejection fraction (HFpEF). METHODS: We performed a single-center prospective, randomized, case-control study in consecutive acute HFpEF (left ventricle ejection fraction, LVEF ≥ 45%) patients with sleep-disordered breathing (SDB, apnea-hypopnea index, AHI > 15/h) and prevalence of CSA. RESULTS: We included ten consecutive patients randomized for ASV on top of standard therapy for acute heart failure (group 1) versus standard care alone (group 2). ASV therapy significantly reduced AHI and CSA. An improvement in cardiac diastolic function was seen in group 1 compared to group 2 (E/E' 17.5 to 9.6, p

Original language	English
Pages (from-to)	287-291
Number of pages	5
Journal	Sleep and Breathing
Volume	23
Issue number	1
DOIs	https://doi.org/10.1007/s11325-018-1681-z
Publication status	Published - Mar 2019

Keywords

Adaptive servo-ventilation
Central sleep apnea
Diastolic function
Heart failure with preserved ejection fraction
Right ventricle
Acute Disease
Aged
Case-Control Studies
Comorbidity
Continuous Positive Airway Pressure/*methods
Diastole/*physiology
Echocardiography
Female
Heart Failure/physiopathology/*therapy
Humans
Male
Middle Aged
Natriuretic Peptide, Brain/*blood
Prospective Studies
Sleep Apnea Syndromes/physiopathology/*therapy
Sleep Apnea, Central/physiopathology/*therapy
Stroke Volume/*physiology
Ventricular Function, Right/physiology

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10.1007/s11325-018-1681-z

https://pubmed.ncbi.nlm.nih.gov/29948858

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D'Elia, E., Ferrero, P., Vittori, C., Iacovoni, A., Grosu, A., Gori, M., Duino, V., Perlini, S., & Senni, M. (2019). Beneficial effects of adaptive servo-ventilation on natriuretic peptides and diastolic function in acute heart failure patients with preserved ejection fraction and sleep-disordered breathing. Sleep and Breathing, 23(1), 287-291. https://doi.org/10.1007/s11325-018-1681-z

Beneficial effects of adaptive servo-ventilation on natriuretic peptides and diastolic function in acute heart failure patients with preserved ejection fraction and sleep-disordered breathing. / D'Elia, E; Ferrero, P; Vittori, C; Iacovoni, A; Grosu, A; Gori, M; Duino, V; Perlini, S; Senni, Michele.

In: Sleep and Breathing, Vol. 23, No. 1, 03.2019, p. 287-291.

Research output: Contribution to journal › Article › peer-review

D'Elia, E, Ferrero, P, Vittori, C, Iacovoni, A, Grosu, A, Gori, M, Duino, V, Perlini, S & Senni, M 2019, 'Beneficial effects of adaptive servo-ventilation on natriuretic peptides and diastolic function in acute heart failure patients with preserved ejection fraction and sleep-disordered breathing', Sleep and Breathing, vol. 23, no. 1, pp. 287-291. https://doi.org/10.1007/s11325-018-1681-z

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abstract = "PURPOSE: Adaptive servo-ventilation (ASV) is a ventilator algorithm able to correct breathing through anticyclic support of breathing in patients with central sleep apnea (CSA). So far, very few data exist regarding the role of ASV on acute heart failure with preserved ejection fraction (HFpEF). METHODS: We performed a single-center prospective, randomized, case-control study in consecutive acute HFpEF (left ventricle ejection fraction, LVEF ≥ 45%) patients with sleep-disordered breathing (SDB, apnea-hypopnea index, AHI > 15/h) and prevalence of CSA. RESULTS: We included ten consecutive patients randomized for ASV on top of standard therapy for acute heart failure (group 1) versus standard care alone (group 2). ASV therapy significantly reduced AHI and CSA. An improvement in cardiac diastolic function was seen in group 1 compared to group 2 (E/E' 17.5 to 9.6, p ",

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AU - Vittori, C

AU - Iacovoni, A

AU - Grosu, A

AU - Gori, M

AU - Duino, V

AU - Perlini, S

AU - Senni, Michele

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