Beneficial effects of adaptive servo-ventilation on natriuretic peptides and diastolic function in acute heart failure patients with preserved ejection fraction and sleep-disordered breathing

E D'Elia; P Ferrero; C Vittori; A Iacovoni; A Grosu; M Gori; V Duino; S Perlini; Michele Senni

doi:10.1007/s11325-018-1681-z

Beneficial effects of adaptive servo-ventilation on natriuretic peptides and diastolic function in acute heart failure patients with preserved ejection fraction and sleep-disordered breathing

E D'Elia, P Ferrero, C Vittori, A Iacovoni, A Grosu, M Gori, V Duino, S Perlini, Michele Senni

Research output: Contribution to journal › Article › peer-review

Abstract

PURPOSE: Adaptive servo-ventilation (ASV) is a ventilator algorithm able to correct breathing through anticyclic support of breathing in patients with central sleep apnea (CSA). So far, very few data exist regarding the role of ASV on acute heart failure with preserved ejection fraction (HFpEF). METHODS: We performed a single-center prospective, randomized, case-control study in consecutive acute HFpEF (left ventricle ejection fraction, LVEF ≥ 45%) patients with sleep-disordered breathing (SDB, apnea-hypopnea index, AHI > 15/h) and prevalence of CSA. RESULTS: We included ten consecutive patients randomized for ASV on top of standard therapy for acute heart failure (group 1) versus standard care alone (group 2). ASV therapy significantly reduced AHI and CSA. An improvement in cardiac diastolic function was seen in group 1 compared to group 2 (E/E' 17.5 to 9.6, p

Original language	English
Pages (from-to)	287-291
Number of pages	5
Journal	Sleep and Breathing
Volume	23
Issue number	1
DOIs	https://doi.org/10.1007/s11325-018-1681-z
Publication status	Published - Mar 2019

Keywords

Adaptive servo-ventilation
Central sleep apnea
Diastolic function
Heart failure with preserved ejection fraction
Right ventricle
Acute Disease
Aged
Case-Control Studies
Comorbidity
Continuous Positive Airway Pressure/*methods
Diastole/*physiology
Echocardiography
Female
Heart Failure/physiopathology/*therapy
Humans
Male
Middle Aged
Natriuretic Peptide, Brain/*blood
Prospective Studies
Sleep Apnea Syndromes/physiopathology/*therapy
Sleep Apnea, Central/physiopathology/*therapy
Stroke Volume/*physiology
Ventricular Function, Right/physiology

Access to Document

10.1007/s11325-018-1681-z

https://pubmed.ncbi.nlm.nih.gov/29948858

Cite this

D'Elia, E., Ferrero, P., Vittori, C., Iacovoni, A., Grosu, A., Gori, M., Duino, V., Perlini, S., & Senni, M. (2019). Beneficial effects of adaptive servo-ventilation on natriuretic peptides and diastolic function in acute heart failure patients with preserved ejection fraction and sleep-disordered breathing. Sleep and Breathing, 23(1), 287-291. https://doi.org/10.1007/s11325-018-1681-z

D'Elia, E, Ferrero, P, Vittori, C, Iacovoni, A, Grosu, A, Gori, M, Duino, V, Perlini, S & Senni, M 2019, 'Beneficial effects of adaptive servo-ventilation on natriuretic peptides and diastolic function in acute heart failure patients with preserved ejection fraction and sleep-disordered breathing', Sleep and Breathing, vol. 23, no. 1, pp. 287-291. https://doi.org/10.1007/s11325-018-1681-z

@article{27802cb439814bb7b5f2eaeb2999ed87,

title = "Beneficial effects of adaptive servo-ventilation on natriuretic peptides and diastolic function in acute heart failure patients with preserved ejection fraction and sleep-disordered breathing",

abstract = "PURPOSE: Adaptive servo-ventilation (ASV) is a ventilator algorithm able to correct breathing through anticyclic support of breathing in patients with central sleep apnea (CSA). So far, very few data exist regarding the role of ASV on acute heart failure with preserved ejection fraction (HFpEF). METHODS: We performed a single-center prospective, randomized, case-control study in consecutive acute HFpEF (left ventricle ejection fraction, LVEF ≥ 45%) patients with sleep-disordered breathing (SDB, apnea-hypopnea index, AHI > 15/h) and prevalence of CSA. RESULTS: We included ten consecutive patients randomized for ASV on top of standard therapy for acute heart failure (group 1) versus standard care alone (group 2). ASV therapy significantly reduced AHI and CSA. An improvement in cardiac diastolic function was seen in group 1 compared to group 2 (E/E' 17.5 to 9.6, p ",

keywords = "Adaptive servo-ventilation, Central sleep apnea, Diastolic function, Heart failure with preserved ejection fraction, Right ventricle, Acute Disease, Aged, Case-Control Studies, Comorbidity, Continuous Positive Airway Pressure/*methods, Diastole/*physiology, Echocardiography, Female, Heart Failure/physiopathology/*therapy, Humans, Male, Middle Aged, Natriuretic Peptide, Brain/*blood, Prospective Studies, Sleep Apnea Syndromes/physiopathology/*therapy, Sleep Apnea, Central/physiopathology/*therapy, Stroke Volume/*physiology, Ventricular Function, Right/physiology",

author = "E D'Elia and P Ferrero and C Vittori and A Iacovoni and A Grosu and M Gori and V Duino and S Perlini and Michele Senni",

year = "2019",

month = mar,

doi = "10.1007/s11325-018-1681-z",

language = "English",

volume = "23",

pages = "287--291",

journal = "Sleep and Breathing",

issn = "1520-9512",

publisher = "Springer Verlag",

number = "1",

}

TY - JOUR

T1 - Beneficial effects of adaptive servo-ventilation on natriuretic peptides and diastolic function in acute heart failure patients with preserved ejection fraction and sleep-disordered breathing

AU - D'Elia, E

AU - Ferrero, P

AU - Vittori, C

AU - Iacovoni, A

AU - Grosu, A

AU - Gori, M

AU - Duino, V

AU - Perlini, S

AU - Senni, Michele

PY - 2019/3

Y1 - 2019/3

N2 - PURPOSE: Adaptive servo-ventilation (ASV) is a ventilator algorithm able to correct breathing through anticyclic support of breathing in patients with central sleep apnea (CSA). So far, very few data exist regarding the role of ASV on acute heart failure with preserved ejection fraction (HFpEF). METHODS: We performed a single-center prospective, randomized, case-control study in consecutive acute HFpEF (left ventricle ejection fraction, LVEF ≥ 45%) patients with sleep-disordered breathing (SDB, apnea-hypopnea index, AHI > 15/h) and prevalence of CSA. RESULTS: We included ten consecutive patients randomized for ASV on top of standard therapy for acute heart failure (group 1) versus standard care alone (group 2). ASV therapy significantly reduced AHI and CSA. An improvement in cardiac diastolic function was seen in group 1 compared to group 2 (E/E' 17.5 to 9.6, p

AB - PURPOSE: Adaptive servo-ventilation (ASV) is a ventilator algorithm able to correct breathing through anticyclic support of breathing in patients with central sleep apnea (CSA). So far, very few data exist regarding the role of ASV on acute heart failure with preserved ejection fraction (HFpEF). METHODS: We performed a single-center prospective, randomized, case-control study in consecutive acute HFpEF (left ventricle ejection fraction, LVEF ≥ 45%) patients with sleep-disordered breathing (SDB, apnea-hypopnea index, AHI > 15/h) and prevalence of CSA. RESULTS: We included ten consecutive patients randomized for ASV on top of standard therapy for acute heart failure (group 1) versus standard care alone (group 2). ASV therapy significantly reduced AHI and CSA. An improvement in cardiac diastolic function was seen in group 1 compared to group 2 (E/E' 17.5 to 9.6, p

KW - Adaptive servo-ventilation

KW - Central sleep apnea

KW - Diastolic function

KW - Heart failure with preserved ejection fraction

KW - Right ventricle

KW - Acute Disease

KW - Aged

KW - Case-Control Studies

KW - Comorbidity

KW - Continuous Positive Airway Pressure/methods

KW - Diastole/physiology

KW - Echocardiography

KW - Female

KW - Heart Failure/physiopathology/therapy

KW - Humans

KW - Male

KW - Middle Aged

KW - Natriuretic Peptide, Brain/blood

KW - Prospective Studies

KW - Sleep Apnea Syndromes/physiopathology/therapy

KW - Sleep Apnea, Central/physiopathology/therapy

KW - Stroke Volume/physiology

KW - Ventricular Function, Right/physiology

U2 - 10.1007/s11325-018-1681-z

DO - 10.1007/s11325-018-1681-z

M3 - Article

VL - 23

SP - 287

EP - 291

JO - Sleep and Breathing

JF - Sleep and Breathing

SN - 1520-9512

IS - 1

ER -

Beneficial effects of adaptive servo-ventilation on natriuretic peptides and diastolic function in acute heart failure patients with preserved ejection fraction and sleep-disordered breathing

Abstract

Keywords

Access to Document

Fingerprint

Cite this