Abstract
Therapy for ischaemic congestive heart failure has been well documented in patients with angina. The goal of this study was to compare the benefit of revascularization in patients with and without chest pain. A series of 180 patients with ischaemic heart failure symptoms (New York Heart Association III-IV class) and low ejection fraction (28±9%) were recruited and followed for 3 years. Group A, 97/180 patients, had chest pain. Group B, 83/180 patients, did not have angina. The two groups did not differ with respect to known determinants of postinfarction prognosis. The relative presence of viable tissue versus scar was defined by Thallium-201 uptake. Intraoperative mortality was 5 and 7% in Groups A and B (P=not significant); in particular, in both groups, it was lower when only patients with mostly viable myocardium were considered. At 6 months, the presence of viable myocardium was highly predictive of improvement of heart failure symptoms and wall motion abnormalities. At 3 years, revascularized patients of Group A with mostly viable myocardium had a survival of 89% compared to 87% for corresponding Group B patients (P=not significant). In conclusion, similarly to patients with angina, patients with left ventricular dysfunction, maintained viability and without anginal symptoms may benefit from coronary revascularization.
| Original language | English |
|---|---|
| Pages (from-to) | 9-15 |
| Number of pages | 7 |
| Journal | Interactive Cardiovascular and Thoracic Surgery |
| Volume | 1 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Sep 2002 |
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Keywords
- Ischemic heart failure
- Prognosis
- Revascularization
- Viability
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Pulmonary and Respiratory Medicine
- Surgery
Cite this
Beneficial effects of coronary revascularization in patients with ischaemic left ventricular dysfunction with and without anginal symptoms. / Gimelli, Alessia; Neto, J. A M; Marcassa, Claudio; Ferrazzi, Paolo; Glauber, Mattia; Marzullo, Paolo.
In: Interactive Cardiovascular and Thoracic Surgery, Vol. 1, No. 1, 09.2002, p. 9-15.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Beneficial effects of coronary revascularization in patients with ischaemic left ventricular dysfunction with and without anginal symptoms
AU - Gimelli, Alessia
AU - Neto, J. A M
AU - Marcassa, Claudio
AU - Ferrazzi, Paolo
AU - Glauber, Mattia
AU - Marzullo, Paolo
PY - 2002/9
Y1 - 2002/9
N2 - Therapy for ischaemic congestive heart failure has been well documented in patients with angina. The goal of this study was to compare the benefit of revascularization in patients with and without chest pain. A series of 180 patients with ischaemic heart failure symptoms (New York Heart Association III-IV class) and low ejection fraction (28±9%) were recruited and followed for 3 years. Group A, 97/180 patients, had chest pain. Group B, 83/180 patients, did not have angina. The two groups did not differ with respect to known determinants of postinfarction prognosis. The relative presence of viable tissue versus scar was defined by Thallium-201 uptake. Intraoperative mortality was 5 and 7% in Groups A and B (P=not significant); in particular, in both groups, it was lower when only patients with mostly viable myocardium were considered. At 6 months, the presence of viable myocardium was highly predictive of improvement of heart failure symptoms and wall motion abnormalities. At 3 years, revascularized patients of Group A with mostly viable myocardium had a survival of 89% compared to 87% for corresponding Group B patients (P=not significant). In conclusion, similarly to patients with angina, patients with left ventricular dysfunction, maintained viability and without anginal symptoms may benefit from coronary revascularization.
AB - Therapy for ischaemic congestive heart failure has been well documented in patients with angina. The goal of this study was to compare the benefit of revascularization in patients with and without chest pain. A series of 180 patients with ischaemic heart failure symptoms (New York Heart Association III-IV class) and low ejection fraction (28±9%) were recruited and followed for 3 years. Group A, 97/180 patients, had chest pain. Group B, 83/180 patients, did not have angina. The two groups did not differ with respect to known determinants of postinfarction prognosis. The relative presence of viable tissue versus scar was defined by Thallium-201 uptake. Intraoperative mortality was 5 and 7% in Groups A and B (P=not significant); in particular, in both groups, it was lower when only patients with mostly viable myocardium were considered. At 6 months, the presence of viable myocardium was highly predictive of improvement of heart failure symptoms and wall motion abnormalities. At 3 years, revascularized patients of Group A with mostly viable myocardium had a survival of 89% compared to 87% for corresponding Group B patients (P=not significant). In conclusion, similarly to patients with angina, patients with left ventricular dysfunction, maintained viability and without anginal symptoms may benefit from coronary revascularization.
KW - Ischemic heart failure
KW - Prognosis
KW - Revascularization
KW - Viability
UR - http://www.scopus.com/inward/record.url?scp=0345258028&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0345258028&partnerID=8YFLogxK
U2 - 10.1016/S1569-9293(02)00002-6
DO - 10.1016/S1569-9293(02)00002-6
M3 - Article
VL - 1
SP - 9
EP - 15
JO - Interactive Cardiovascular and Thoracic Surgery
JF - Interactive Cardiovascular and Thoracic Surgery
SN - 1569-9293
IS - 1
ER -