Beneficial electrophysiological effects of trimetazidine in patients with postischemic chronic heart failure

Michela Cera, Anna Salerno, Gabriele Fragasso, Claudia Montanaro, Chiara Gardini, Giovanni Marinosci, Francesco Arioli, Roberto Spoladore, Alberto Facchini, Cosmo Godino, Alberto Margonato

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of the study was to assess whether trimetazidine (TMZ) could affect dispersion of atrial depolarization and ventricular repolarization. Corrected QT interval (QTc), QTc dispersion (QTc-d), Tpeak-Tend, and Tpeak-Tend dispersion (Tpeak-Tend-d) were measured in 30 patients with chronic heart failure (CHF) before and 6 months after randomization to conventional therapy plus TMZ (17 patients) or conventional therapy alone (13 patients). After 6 months, QTc was significantly reduced in both groups, whereas QT-peak was increased only in control group. Tpeak-Tend-d decreased (from 63.53 ± 24.73 to 42.35 ± 21.07 milliseconds, P =.006) only in TMZ group. When subgrouped according to CHF etiology, only ischemic patients on TMZ showed Tpeak-Tend-d reduction (65.00 ± 27.14 vs 36.67 ± 11.55 milliseconds, P =.001 in ischemic patients; 60.00 ± 20.00 vs 56.00 ± 33.86 milliseconds, P = NS, in nonischemic). These electrophysiological properties indicate an undiscovered mechanism of action of TMZ, which could be useful in conditions at risk of major arrhythmias.

Original languageEnglish
Pages (from-to)24-30
Number of pages7
JournalJournal of Cardiovascular Pharmacology and Therapeutics
Volume15
Issue number1
DOIs
Publication statusPublished - Mar 2010

Keywords

  • Electrophysiological effect
  • Heart failure
  • Tpeak-Tend dispersion
  • Trimetazidine
  • Ventricular repolarization

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Cardiology and Cardiovascular Medicine

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