Benefits and drawbacks of open partial horizontal laryngectomies, part A: Early- to intermediate-stage glottic carcinoma

Giovanni Succo, Erika Crosetti, Andy Bertolin, Marco Lucioni, Alessandra Caracciolo, Valentina Panetta, Andrea Elio Sprio, Giovanni Nicolao Berta, Giuseppe Rizzotto

Research output: Contribution to journalArticle

Abstract

Background: Laryngeal squamous cell carcinoma (SCC) accounts for 1.9% of cancers worldwide. Most of these are diagnosed in the early stages (T1-T2, and N0). For these, a larynx preserving/conserving option is preferable. Beyond transoral laser microsurgery (TLM), open partial horizontal laryngectomy is a function-sparing surgical technique used to treat laryngeal SCC. Methods: We retrospectively analyzed the clinical outcomes of 216 patients who underwent open partial horizontal laryngectomy for glottic cT2 laryngeal cancer. Results: Five-year overall survival (OS), disease-specific survival (DFS), locoregional control, local control, laryngeal function preservation, and laryngectomy-free survival rates were 93.1%, 98.0%, 97.1%, 97.5%, 97.8%, and 98.5%, respectively. Disease controls were significantly affected by previous treatment and type of surgery used. Conclusion: Although TLM for cT2 laryngeal cancer with unimpaired vocal cord mobility still represents a sound option, open partial horizontal laryngectomy offers higher local control and laryngeal preservation rates for selected patients with impaired mobility of vocal cords combined with involvement of the paraglottic space.

Original languageEnglish
JournalHead and Neck
DOIs
Publication statusAccepted/In press - 2015

Fingerprint

Laryngectomy
Tongue
Carcinoma
Laryngeal Neoplasms
Microsurgery
Vocal Cords
Squamous Cell Carcinoma
Lasers
Survival
Larynx
Survival Rate
Neoplasms
Therapeutics

Keywords

  • Glottis cancer
  • Laryngeal cancer
  • Open partial laryngectomy
  • Supracricoid partial laryngectomy
  • Supratracheal partial laryngectomy
  • TNM staging

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Benefits and drawbacks of open partial horizontal laryngectomies, part A : Early- to intermediate-stage glottic carcinoma. / Succo, Giovanni; Crosetti, Erika; Bertolin, Andy; Lucioni, Marco; Caracciolo, Alessandra; Panetta, Valentina; Sprio, Andrea Elio; Berta, Giovanni Nicolao; Rizzotto, Giuseppe.

In: Head and Neck, 2015.

Research output: Contribution to journalArticle

Succo, Giovanni ; Crosetti, Erika ; Bertolin, Andy ; Lucioni, Marco ; Caracciolo, Alessandra ; Panetta, Valentina ; Sprio, Andrea Elio ; Berta, Giovanni Nicolao ; Rizzotto, Giuseppe. / Benefits and drawbacks of open partial horizontal laryngectomies, part A : Early- to intermediate-stage glottic carcinoma. In: Head and Neck. 2015.
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abstract = "Background: Laryngeal squamous cell carcinoma (SCC) accounts for 1.9{\%} of cancers worldwide. Most of these are diagnosed in the early stages (T1-T2, and N0). For these, a larynx preserving/conserving option is preferable. Beyond transoral laser microsurgery (TLM), open partial horizontal laryngectomy is a function-sparing surgical technique used to treat laryngeal SCC. Methods: We retrospectively analyzed the clinical outcomes of 216 patients who underwent open partial horizontal laryngectomy for glottic cT2 laryngeal cancer. Results: Five-year overall survival (OS), disease-specific survival (DFS), locoregional control, local control, laryngeal function preservation, and laryngectomy-free survival rates were 93.1{\%}, 98.0{\%}, 97.1{\%}, 97.5{\%}, 97.8{\%}, and 98.5{\%}, respectively. Disease controls were significantly affected by previous treatment and type of surgery used. Conclusion: Although TLM for cT2 laryngeal cancer with unimpaired vocal cord mobility still represents a sound option, open partial horizontal laryngectomy offers higher local control and laryngeal preservation rates for selected patients with impaired mobility of vocal cords combined with involvement of the paraglottic space.",
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AU - Succo, Giovanni

AU - Crosetti, Erika

AU - Bertolin, Andy

AU - Lucioni, Marco

AU - Caracciolo, Alessandra

AU - Panetta, Valentina

AU - Sprio, Andrea Elio

AU - Berta, Giovanni Nicolao

AU - Rizzotto, Giuseppe

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