Benefits and drawbacks of open partial horizontal laryngectomies, part A: Early- to intermediate-stage glottic carcinoma

Giovanni Succo, Erika Crosetti, Andy Bertolin, Marco Lucioni, Alessandra Caracciolo, Valentina Panetta, Andrea Elio Sprio, Giovanni Nicolao Berta, Giuseppe Rizzotto

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Laryngeal squamous cell carcinoma (SCC) accounts for 1.9% of cancers worldwide. Most of these are diagnosed in the early stages (T1-T2, and N0). For these, a larynx preserving/conserving option is preferable. Beyond transoral laser microsurgery (TLM), open partial horizontal laryngectomy is a function-sparing surgical technique used to treat laryngeal SCC. Methods: We retrospectively analyzed the clinical outcomes of 216 patients who underwent open partial horizontal laryngectomy for glottic cT2 laryngeal cancer. Results: Five-year overall survival (OS), disease-specific survival (DFS), locoregional control, local control, laryngeal function preservation, and laryngectomy-free survival rates were 93.1%, 98.0%, 97.1%, 97.5%, 97.8%, and 98.5%, respectively. Disease controls were significantly affected by previous treatment and type of surgery used. Conclusion: Although TLM for cT2 laryngeal cancer with unimpaired vocal cord mobility still represents a sound option, open partial horizontal laryngectomy offers higher local control and laryngeal preservation rates for selected patients with impaired mobility of vocal cords combined with involvement of the paraglottic space.

Original languageEnglish
JournalHead and Neck
DOIs
Publication statusAccepted/In press - 2015

Keywords

  • Glottis cancer
  • Laryngeal cancer
  • Open partial laryngectomy
  • Supracricoid partial laryngectomy
  • Supratracheal partial laryngectomy
  • TNM staging

ASJC Scopus subject areas

  • Otorhinolaryngology

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