Benefits and drawbacks of open partial horizontal laryngectomies, part B: Intermediate and selected advanced stage laryngeal carcinoma

Giovanni Succo, Erika Crosetti, Andy Bertolin, Marco Lucioni, Giulia Arrigoni, Valentina Panetta, Andrea E. Sprio, Giovanni N. Berta, Giuseppe Rizzotto

Research output: Contribution to journalArticle

Abstract

Background: Cancer of the larynx in the intermediate/advanced stage still presents a major challenge in terms of controlling the disease and preserving the organ. Among therapeutic options, open partial horizontal laryngectomy is proposed as a function-sparing surgical technique. Methods: We analyzed the clinical outcomes of 555 patients with laryngeal cancer staged pT3 to pT4a who underwent open partial horizontal laryngectomy. Results: Five-year overall survival (OS), disease-free survival (DFS), locoregional control, local control, laryngectomy-free survival, and laryngeal function preservation rates were 84.6%, 84.2%, 86.3%, 90.6%, 93.3%, and 91.2%, respectively. DFS, locoregional control, and laryngeal function preservation rates were significantly affected by pT4a staging (68.1%, 71.7%, and 78.0%, respectively), whereas pN+ influenced only DFS (≤72.6%) and locoregional control (≤79.6%). Conclusions: Open partial horizontal laryngectomy with a modular approach can be considered effective in terms of prognostic and functional results in intermediate-stage and selected advanced-stage laryngeal cancers, even with subglottic extension.

Original languageEnglish
JournalHead and Neck
DOIs
Publication statusAccepted/In press - 2015

Keywords

  • Laryngeal cancer
  • Laryngeal function-sparing protocol
  • Open partial laryngectomy
  • Supracricoid partial laryngectomy
  • Supratracheal partial laryngectomy

ASJC Scopus subject areas

  • Otorhinolaryngology

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