Benefits of multistrain bacteria formulations for health

L. Laterza, G. Gibiino, F. Scaldaferri, A. Gasbarrini

Research output: Contribution to journalArticle

Abstract

Gut microbiota dysfunction is associated with multiple gastrointestinal and extra-gastrointestinal diseases, thus the possibility of its modulation with prebiotics, probiotics and symbiotics has gained interest in the last years. Many probiotics are available on the market and products characterized by combination of multiple strains have been proposed as particularly effective. However, evidences supporting their efficacy are often inadequate and not homogenous. We reviewed available data on clinical efficacy of multistrain probiotics and symbiotics in gastrointestinal diseases in adults, focusing on data from randomised, double-blind, placebo-controlled clinical trials. Twenty-nine multistrain products satisfied inclusion criteria. The principal areas of application are irritable bowel syndrome, Helicobacter pylori eradication and antibiotic-associated diarrhoea. The most represented probiotic species in the different probiotic formulations was L. acidophilus. The combination of L. paracasei, L. plantarum, L. acidophilus, L. delbrueckii subsp. bulgaricus, B. longum, B. infantis, B. breve and S. thermophilus (VSL#3) showed the highest number of RCTs.

Original languageEnglish
Pages (from-to)531-546
Number of pages16
JournalJournal of Functional Foods
Volume47
DOIs
Publication statusPublished - Aug 1 2018

Fingerprint

Probiotics
probiotics
Bacteria
bacteria
Health
Gastrointestinal Diseases
digestive system diseases
Prebiotics
Helicobacter pylori
Irritable Bowel Syndrome
Controlled Clinical Trials
prebiotics
intestinal microorganisms
placebos
clinical trials
Diarrhea
diarrhea
antibiotics
Placebos
Anti-Bacterial Agents

Keywords

  • Gastrointestinal disease
  • Gut microbiota
  • H. pylori
  • Irritable bowel syndrome
  • Multistrain probiotics
  • VSL#3

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Benefits of multistrain bacteria formulations for health. / Laterza, L.; Gibiino, G.; Scaldaferri, F.; Gasbarrini, A.

In: Journal of Functional Foods, Vol. 47, 01.08.2018, p. 531-546.

Research output: Contribution to journalArticle

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