Benzodiazepine receptors': Correlation with pharmacological responses in living animals

Tiziana Mennini; Silvio Garattini

doi:10.1016/0024-3205(82)90094-7

Benzodiazepine receptors': Correlation with pharmacological responses in living animals

Tiziana Mennini, Silvio Garattini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

The data relating the pharmacological activities of benzodiazepines to in vivo occupancy of their receptor sites is reviewed, in the light of the complexity of evaluating pharmacodynamic parameters in living animals. Methodological problems in the measurement of in vivo receptor occupancy and species differences in benzodiazepine metabolism are considered in detail.

Original language	English
Pages (from-to)	2025-2035
Number of pages	11
Journal	Life Sciences
Volume	31
Issue number	19
DOIs	https://doi.org/10.1016/0024-3205(82)90094-7
Publication status	Published - Nov 8 1982

ASJC Scopus subject areas

Pharmacology

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10.1016/0024-3205(82)90094-7

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title = "Benzodiazepine receptors': Correlation with pharmacological responses in living animals",

abstract = "The data relating the pharmacological activities of benzodiazepines to in vivo occupancy of their receptor sites is reviewed, in the light of the complexity of evaluating pharmacodynamic parameters in living animals. Methodological problems in the measurement of in vivo receptor occupancy and species differences in benzodiazepine metabolism are considered in detail.",

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Benzodiazepine receptors': Correlation with pharmacological responses in living animals

Abstract

ASJC Scopus subject areas

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