Benzodiazepines: Relationship between pharmacological activity in the rat and in vivo receptor binding

T. Mennini, S. Cotecchia, S. Caccia, S. Garattini

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

When given at ED50 antileptazol several benzodiazepines displace 3H-Diazepam bound in vivo to rat brain by about 50%, in spite of the differences between pharmacological potencies and metabolism. No displacement is found in cerebellum, even when the concentrations of displacing drugs are comparable. The possibility of the presence of multiple benzodiazepine receptors in brain and cerebellum is discussed in relation with their pharmacological activity.

Original languageEnglish
Pages (from-to)529-532
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume16
Issue number4
DOIs
Publication statusPublished - 1982

Fingerprint

Benzodiazepines
Cerebellum
Rats
Brain
Pharmacology
GABA-A Receptors
Diazepam
Metabolism
Pharmaceutical Preparations

Keywords

  • Antileptazol activity
  • Anxiolytic effect
  • Benzodiazepine receptors
  • Camazepam
  • Clobazam
  • Diazepam
  • In vivo receptor binding
  • Oxazepam
  • Temazepam

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Benzodiazepines : Relationship between pharmacological activity in the rat and in vivo receptor binding. / Mennini, T.; Cotecchia, S.; Caccia, S.; Garattini, S.

In: Pharmacology, Biochemistry and Behavior, Vol. 16, No. 4, 1982, p. 529-532.

Research output: Contribution to journalArticle

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