Abstract
When given at ED50 antileptazol several benzodiazepines displace 3H-Diazepam bound in vivo to rat brain by about 50%, in spite of the differences between pharmacological potencies and metabolism. No displacement is found in cerebellum, even when the concentrations of displacing drugs are comparable. The possibility of the presence of multiple benzodiazepine receptors in brain and cerebellum is discussed in relation with their pharmacological activity.
Original language | English |
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Pages (from-to) | 529-532 |
Number of pages | 4 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 16 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1982 |
Keywords
- Antileptazol activity
- Anxiolytic effect
- Benzodiazepine receptors
- Camazepam
- Clobazam
- Diazepam
- In vivo receptor binding
- Oxazepam
- Temazepam
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology