Benzodiazepines: Relationship between pharmacological activity in the rat and in vivo receptor binding

T. Mennini, S. Cotecchia, S. Caccia, S. Garattini

Research output: Contribution to journalArticlepeer-review

Abstract

When given at ED50 antileptazol several benzodiazepines displace 3H-Diazepam bound in vivo to rat brain by about 50%, in spite of the differences between pharmacological potencies and metabolism. No displacement is found in cerebellum, even when the concentrations of displacing drugs are comparable. The possibility of the presence of multiple benzodiazepine receptors in brain and cerebellum is discussed in relation with their pharmacological activity.

Original languageEnglish
Pages (from-to)529-532
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume16
Issue number4
DOIs
Publication statusPublished - 1982

Keywords

  • Antileptazol activity
  • Anxiolytic effect
  • Benzodiazepine receptors
  • Camazepam
  • Clobazam
  • Diazepam
  • In vivo receptor binding
  • Oxazepam
  • Temazepam

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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