Abstract
When given at ED50 antileptazol several benzodiazepines displace 3H-Diazepam bound in vivo to rat brain by about 50%, in spite of the differences between pharmacological potencies and metabolism. No displacement is found in cerebellum, even when the concentrations of displacing drugs are comparable. The possibility of the presence of multiple benzodiazepine receptors in brain and cerebellum is discussed in relation with their pharmacological activity.
| Original language | English |
|---|---|
| Pages (from-to) | 529-532 |
| Number of pages | 4 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 16 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1982 |
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Keywords
- Antileptazol activity
- Anxiolytic effect
- Benzodiazepine receptors
- Camazepam
- Clobazam
- Diazepam
- In vivo receptor binding
- Oxazepam
- Temazepam
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
Cite this
Benzodiazepines : Relationship between pharmacological activity in the rat and in vivo receptor binding. / Mennini, T.; Cotecchia, S.; Caccia, S.; Garattini, S.
In: Pharmacology, Biochemistry and Behavior, Vol. 16, No. 4, 1982, p. 529-532.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Benzodiazepines
T2 - Relationship between pharmacological activity in the rat and in vivo receptor binding
AU - Mennini, T.
AU - Cotecchia, S.
AU - Caccia, S.
AU - Garattini, S.
PY - 1982
Y1 - 1982
N2 - When given at ED50 antileptazol several benzodiazepines displace 3H-Diazepam bound in vivo to rat brain by about 50%, in spite of the differences between pharmacological potencies and metabolism. No displacement is found in cerebellum, even when the concentrations of displacing drugs are comparable. The possibility of the presence of multiple benzodiazepine receptors in brain and cerebellum is discussed in relation with their pharmacological activity.
AB - When given at ED50 antileptazol several benzodiazepines displace 3H-Diazepam bound in vivo to rat brain by about 50%, in spite of the differences between pharmacological potencies and metabolism. No displacement is found in cerebellum, even when the concentrations of displacing drugs are comparable. The possibility of the presence of multiple benzodiazepine receptors in brain and cerebellum is discussed in relation with their pharmacological activity.
KW - Antileptazol activity
KW - Anxiolytic effect
KW - Benzodiazepine receptors
KW - Camazepam
KW - Clobazam
KW - Diazepam
KW - In vivo receptor binding
KW - Oxazepam
KW - Temazepam
UR - http://www.scopus.com/inward/record.url?scp=0020083059&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020083059&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(82)90409-9
DO - 10.1016/0091-3057(82)90409-9
M3 - Article
C2 - 6122216
AN - SCOPUS:0020083059
VL - 16
SP - 529
EP - 532
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 4
ER -