Benzydamine inhibits the release of tumor necrosis factor-α and monocyte chemotactic protein-1 by Candida albicans-stimulated human peripheral blood cells

M. Sironi, C. Milanese, A. Vecchi, L. Polenzani, A. Guglielmotti, I. Coletta, C. Landolfi, L. Soldo, A. Mantovani, M. Pinza

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Benzydamine is a non-steroidal antiinflammatory drug, devoid of activity on arachidonic acid metabolism, which is extensively used as a topical drug in inflammatory conditions, particularly for the treatment of bacterial vaginosis and Candida albicans-sustained vaginitis. In the present study the effects of benzydamine on the production of several inflammatory cytokines were examined in cultures of Candida albicans-stimulated human mononuclear cells. Benzydamine (6.25-50 μM) inhibited Candida-induced tumor necrosis factor-α and, to a lesser extent, interleukin-1β production, whereas it did not affect interleukin-6 release. Benzydamine also blocked monocyte chemotactic protein-1 secretion, but it did not affect interleukin-8 production. Unlike benzydamine, ibuprofen and naproxen, two non-steroidal antiinflammatory drugs also used topically, were unable to suppress inflammatory lymphokine production from Candida-activated mononuclear cells. These data suggest that benzydamine may be effective in local Candida infections at least in part by suppressing inflammatory cytokine and monokine production in the vaginal mucosa and consequently decreasing their levels in vaginal secretions.

Original languageEnglish
Pages (from-to)118-122
Number of pages5
JournalInternational Journal of Clinical & Laboratory Research
Volume27
Issue number2
Publication statusPublished - Jul 1997

Fingerprint

Benzydamine
Candida
Chemokine CCL2
Candida albicans
Blood Cells
Blood
Tumor Necrosis Factor-alpha
Cells
Anti-Inflammatory Agents
Pharmaceutical Preparations
Monokines
Cytokines
Vaginitis
Bacterial Vaginosis
Naproxen
Lymphokines
Ibuprofen
Interleukin-8
Interleukin-1
Arachidonic Acid

Keywords

  • Antiinflammatory drug
  • Candida albicans
  • Chemokines
  • Interleukins
  • Vaginitis

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Benzydamine inhibits the release of tumor necrosis factor-α and monocyte chemotactic protein-1 by Candida albicans-stimulated human peripheral blood cells. / Sironi, M.; Milanese, C.; Vecchi, A.; Polenzani, L.; Guglielmotti, A.; Coletta, I.; Landolfi, C.; Soldo, L.; Mantovani, A.; Pinza, M.

In: International Journal of Clinical & Laboratory Research, Vol. 27, No. 2, 07.1997, p. 118-122.

Research output: Contribution to journalArticle

Sironi, M. ; Milanese, C. ; Vecchi, A. ; Polenzani, L. ; Guglielmotti, A. ; Coletta, I. ; Landolfi, C. ; Soldo, L. ; Mantovani, A. ; Pinza, M. / Benzydamine inhibits the release of tumor necrosis factor-α and monocyte chemotactic protein-1 by Candida albicans-stimulated human peripheral blood cells. In: International Journal of Clinical & Laboratory Research. 1997 ; Vol. 27, No. 2. pp. 118-122.
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