Ber-H2 (anti-CD30)-saporin immunotoxin: A new tool for the treatment of Hodgkin's disease and CD30+ lymphoma: In vitro evaluation

P. L. Tazzari; A. Bolognesi; D. De Totero; B. Falini; R. M. Lemoli; M. R. Soria; S. Pileri; M. Gobbi; H. Stein; L. Flenghi; M. F. Martelli; F. Stirpe

Ber-H2 (anti-CD30)-saporin immunotoxin: A new tool for the treatment of Hodgkin's disease and CD30+ lymphoma: In vitro evaluation

P. L. Tazzari, A. Bolognesi, D. De Totero, B. Falini, R. M. Lemoli, M. R. Soria, S. Pileri, M. Gobbi, H. Stein, L. Flenghi, M. F. Martelli, F. Stirpe

Research output: Contribution to journal › Article

Abstract

An immunotoxin containing an anti-CD30 monoclonal antibody (Ber-H2) and saporin, a ribosome-inactivating protein type 1, is described. It specifically inhibits protein synthesis by Hodgkin derived target cell lines with a very high efficiency (IC₅₀ ranging from 5 x 10^-12 M to 5 x 10^-14 M, as saporin), while irrelevant immunotoxins do not. Present results suggest that this immunotoxin could be used for in vivo therapy as well as for ex vivo bone marrow purging in Hodgkin's disease and CD30+ lymphomas.

Original language	English
Pages (from-to)	203-211
Number of pages	9
Journal	British Journal of Haematology
Volume	81
Issue number	2
Publication status	Published - 1992

ASJC Scopus subject areas

Hematology

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Tazzari, P. L., Bolognesi, A., De Totero, D., Falini, B., Lemoli, R. M., Soria, M. R., Pileri, S., Gobbi, M., Stein, H., Flenghi, L., Martelli, M. F., & Stirpe, F. (1992). Ber-H2 (anti-CD30)-saporin immunotoxin: A new tool for the treatment of Hodgkin's disease and CD30+ lymphoma: In vitro evaluation. British Journal of Haematology, 81(2), 203-211.

Ber-H2 (anti-CD30)-saporin immunotoxin : A new tool for the treatment of Hodgkin's disease and CD30+ lymphoma: In vitro evaluation. / Tazzari, P. L.; Bolognesi, A.; De Totero, D.; Falini, B.; Lemoli, R. M.; Soria, M. R.; Pileri, S.; Gobbi, M.; Stein, H.; Flenghi, L.; Martelli, M. F.; Stirpe, F.

In: British Journal of Haematology, Vol. 81, No. 2, 1992, p. 203-211.

Research output: Contribution to journal › Article

Tazzari, P. L. ; Bolognesi, A. ; De Totero, D. ; Falini, B. ; Lemoli, R. M. ; Soria, M. R. ; Pileri, S. ; Gobbi, M. ; Stein, H. ; Flenghi, L. ; Martelli, M. F. ; Stirpe, F. / Ber-H2 (anti-CD30)-saporin immunotoxin : A new tool for the treatment of Hodgkin's disease and CD30+ lymphoma: In vitro evaluation. In: British Journal of Haematology. 1992 ; Vol. 81, No. 2. pp. 203-211.

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abstract = "An immunotoxin containing an anti-CD30 monoclonal antibody (Ber-H2) and saporin, a ribosome-inactivating protein type 1, is described. It specifically inhibits protein synthesis by Hodgkin derived target cell lines with a very high efficiency (IC50 ranging from 5 x 10-12 M to 5 x 10-14 M, as saporin), while irrelevant immunotoxins do not. Present results suggest that this immunotoxin could be used for in vivo therapy as well as for ex vivo bone marrow purging in Hodgkin's disease and CD30+ lymphomas.",

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