Berberine improves reproductive features in obese Caucasian women with polycystic ovary syndrome independently of changes of insulin sensitivity

Francesco Orio, Giovanna Muscogiuri, Stefano Palomba, Silvia Savastano, Alessio Volpe, Marcello Orio, Giorgio Colarieti, Giovanni Battista La Sala, Annamaria Colao, Francesca Marciano, Antonio Ascione, Pietro Putignano

Research output: Contribution to journalArticle

Abstract

Background and aims: Berberine (BBR) is an isoquinoline derivative alkaloid isolated from Rhizoma Coptidis traditionally used as anti diarrheic and, more recently, as hypolipidemic and insulin sensitizer agent. Thus, BBR could represent a potential therapeutic option for patients with polycystic ovary syndrome (PCOS). The aim of this study was to evaluate the clinical, metabolic and hormonal effects of BBR in PCOS women. Methods: Fifty oligoamenorrheic PCOS obese women and 50 age and Body Mass Index (BMI) matched healthy controls were enrolled. PCOS women received BBR treatment (500mg, 2 times daily) for 6 months. Clinical and biochemical parameters were assessed before and after the treatment period. Results: Total testosterone (p

Original languageEnglish
Journale-SPEN Journal
Volume8
Issue number5
DOIs
Publication statusPublished - Oct 2013

Keywords

  • Berberine
  • BMI
  • FAI
  • Insulin resistance
  • PCOS
  • Testosterone

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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    Orio, F., Muscogiuri, G., Palomba, S., Savastano, S., Volpe, A., Orio, M., Colarieti, G., La Sala, G. B., Colao, A., Marciano, F., Ascione, A., & Putignano, P. (2013). Berberine improves reproductive features in obese Caucasian women with polycystic ovary syndrome independently of changes of insulin sensitivity. e-SPEN Journal, 8(5). https://doi.org/10.1016/j.clnme.2013.07.002