High blood pressure, vascular damage (VD) and glomerular sclerosis (GS) are frequently found in Berger's IgA nephropathy (BN). In the present study the relationships among GS, VD and blood pressure were assessed in 50 patients with biopsy-proved NB and normal renal function. GS was found in 62% of patients and was not related to the grade of VD: GS was present in 5/15 patients without VD and affected more than 15% of glomeruli in 7 patients with minimal VD. GS was not related to the blood pressure levels: 9 of 19 patients (47%) with GS affecting more than 15% of glomeruli were normotensive. VD was more frequent in hypertensive than in normotensive patients, but was often present in the normotensive group: 18 of 28 patients with a VD grade 1-2 were normotensive. VD was not related to the patients' age nor to the duration of nephropathy. Moreover in 34 patients the relationships among GS, VD, blood pressure and plasma renin activity (PRA) were assessed. While hypertensive patients showed low-normal PRA levels, 7 normotensive patients had insignificantly high PRA levels. In PRA normotensive patients GS was not present, while VD was absent in 5 patients and minimal in 2 patients. We conclude that in BN the inflammatory lesion of the mesangium may affect the secretory function of the juxtaglomerular apparatus. Moreover hypertension does not appear to be the only responsible factor for VD. GS is not related to VD and may be the result of continuing immunological glomerular damage.
|Translated title of the contribution||Bergers's nephropathy: Relations between histologic aspects, arterial hypertension and renin plasma activity|
|Number of pages||4|
|Publication status||Published - 1981|
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