Best practice in the administration of analgesia in postoncological surgery

Juan P. Cata, Javier Lasala, Dario Bugada

Research output: Contribution to journalArticlepeer-review


The rationale for using multimodal analgesia after any major surgery is achievement of adequate analgesia while avoiding the unwanted effects of large doses of any analgesic, in particular opioids. There are two reasons why we can hypothesize that multimodal analgesia might have a significant impact on cancer-related outcomes in the context of oncological orthopedic surgery. First, because multimodal analgesia is a key component of enhanced-recovery pathways and can accelerate return to intended oncological therapy. And second, because some of the analgesic used in multimodal analgesia (i.e., COX inhibitors, local analgesics and dexamethasone) can induce apoptosis in cancer cells and/or diminish the inflammatory response during surgery which itself can facilitate tumor growth.

Original languageEnglish
Pages (from-to)273-284
Number of pages12
JournalPain Management
Issue number4
Publication statusPublished - 2015


  • cancer
  • enhanced recovery
  • multimodal analgesia
  • surgery
  • survival

ASJC Scopus subject areas

  • Medicine(all)


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