ESPRESSIONE E DISTRIBUZIONE DELLE INTEGRINE BETA-1 (VLA) NEL RENE UMANO

Translated title of the contribution: Beta-1 integrins in normal human kidney: Expression and distribution pattern

A. Baraldi, L. Furci, A. Di Felice, D. Maccari, M. Ballestri, S. Perrone, G. Zambruno, E. Lusvarghi

Research output: Contribution to journalArticle

Abstract

The expression of α1-6 subunits of the β1 (VLA, Very Late Activation) integrin family was studied in normal human kidney using an amplified immunofluorescence technique. On glomeruli, α1, α2, α3 subunits showed a mesangial-endothelial distribution pattern, while α5 and α6 were present only on the endothelia. α3β1 was the dominant integrin on glomerular capillary wall, being polarized on basolateral surfaces of podocyte foot processes. On the endothelia of arterioles and peritubular capillaries, all subunits but α4 were present. Our results confirm and complete the phenotypical characterization of β1 integrins in kidney: further studies are needed to ascertain a possible role for these molecules in renal diseases.

Translated title of the contributionBeta-1 integrins in normal human kidney: Expression and distribution pattern
Original languageItalian
Pages (from-to)233-238
Number of pages6
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Volume11
Issue number4
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Nephrology

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    Baraldi, A., Furci, L., Di Felice, A., Maccari, D., Ballestri, M., Perrone, S., Zambruno, G., & Lusvarghi, E. (1994). ESPRESSIONE E DISTRIBUZIONE DELLE INTEGRINE BETA-1 (VLA) NEL RENE UMANO. Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia, 11(4), 233-238.