Beta-Adrenoceptor Antagonists and Antianginal Drugs

Research output: Contribution to journalArticlepeer-review


The Side Effects of Drugs Annuals is a series of volumes in which the adverse effects of drugs and adverse reactions to them are surveyed. The series supplements the contents of Meyler's Side Effects of Drugs: the International Encyclopedia of Adverse Drug Reactions and Interactions. This review of the 2014 publications on beta-adrenoceptor antagonists and antianginal drugs covers beta-adrenoceptor antagonists (esmolol, levobunolol, nebivolol, and propranolol, timolol), the potassium channel activator nicorandil, and calcium channel blockers (amlodipine, nicardipine, nifedipine, and verapamil). Highlights include reports of the maternal and pregnancy risk and hepatorenal syndrome after beta-blocker exposure, delirium associated with the use of esmolol, severe bradyarrhythmias with levobunolol and nebivolol, metabolism and electrolyte imbalance in patient treated with nebivolol and propranolol, dermatological effects with the use of propranolol, light-headedness with timolol. Moreover, the review reports cases of methaemoglobinaemia and corneal ulceration with nicorandil. Cases of breast cancer, gingival overgrowth, pulmonary edema, intestinal obstruction, severe hypotension, overdose and poisoning with the use of calcium channel blockers (amlodipine, nifedipine and verapamil) have been described.

Original languageEnglish
JournalSide Effects of Drugs Annual
Publication statusAccepted/In press - 2015


  • Adverse reactions
  • Amlodipine
  • Antianginal drugs
  • Beta-adrenoceptor antagonists
  • Calcium channel blockers
  • Esmolol
  • Levobunolol
  • Nevibolol
  • Nicardipine
  • Nicorandil
  • Nifedipine
  • Propranolol
  • Timolol
  • Verapamil

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Drug guides


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