Beta-amyloid plasma levels in adolescents with anorexia nervosa of the restrictive type

Elisa Conti, Renata Nacinovich, Monica Bomba, Maria E. Raggi, Francesca Neri, Carlo Ferrarese, Lucio Tremolizzo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Reduced plasma leptin and elevated homocysteine (Hcy) are known to lead to increased β-amyloid (Aβ) production, besides being hallmarks of anorexia nervosa (AN) of the restrictive type. AN subjects display several neuropsychiatric manifestations, which may entail Aβ-mediated altered synaptic functions. The aim of this study consisted in assessing Aβ plasma levels in AN patients. Methods: A total of 24 adolescent female AN outpatients were recruited together with 12 age-comparable healthy controls. For each subject we assessed Aβ40 and leptin plasma levels, as well as APOE genotype. Hcy plasma levels were also determined in AN patients who underwent clinical characterization, including the Eating Disorder Inventory-3 (EDI-3), the Children's Depression Inventory (CDI) and the estimation of the speed of BMI loss (DPI, disease progression index). Results: Plasma Aβ40 levels were similar between patients and controls, while a marked reduction was observed for leptin (∼80%) in AN patients. Aβ40 plasma levels failed to correlate with leptin, while a linear correlation was present with Hcy (r = 0.50, p <0.03). Examined clinical features were not related with Aβ40 plasma levels, with the only exception of the DPI (r = 0.47, p <0.03). Conclusion: This exploratory study does not support a significant role for altered Aβ production in AN-associated dysfunctions. Further studies are required to clarify whether exceptions to this conclusion can be drawn for those patients expressing significantly elevated Hcy plasma levels or for those progressing more rapidly.

Original languageEnglish
Pages (from-to)154-157
Number of pages4
JournalNeuropsychobiology
Volume71
Issue number3
DOIs
Publication statusPublished - Jun 1 2015

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Anorexia Nervosa
Amyloid
Homocysteine
Leptin
Disease Progression
Equipment and Supplies
Outpatients
Genotype
Depression

Keywords

  • Anorexia nervosa
  • Homocysteine
  • Plasma leptin
  • β-Amyloid

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Neuropsychology and Physiological Psychology
  • Biological Psychiatry

Cite this

Conti, E., Nacinovich, R., Bomba, M., Raggi, M. E., Neri, F., Ferrarese, C., & Tremolizzo, L. (2015). Beta-amyloid plasma levels in adolescents with anorexia nervosa of the restrictive type. Neuropsychobiology, 71(3), 154-157. https://doi.org/10.1159/000381399

Beta-amyloid plasma levels in adolescents with anorexia nervosa of the restrictive type. / Conti, Elisa; Nacinovich, Renata; Bomba, Monica; Raggi, Maria E.; Neri, Francesca; Ferrarese, Carlo; Tremolizzo, Lucio.

In: Neuropsychobiology, Vol. 71, No. 3, 01.06.2015, p. 154-157.

Research output: Contribution to journalArticle

Conti, E, Nacinovich, R, Bomba, M, Raggi, ME, Neri, F, Ferrarese, C & Tremolizzo, L 2015, 'Beta-amyloid plasma levels in adolescents with anorexia nervosa of the restrictive type', Neuropsychobiology, vol. 71, no. 3, pp. 154-157. https://doi.org/10.1159/000381399
Conti E, Nacinovich R, Bomba M, Raggi ME, Neri F, Ferrarese C et al. Beta-amyloid plasma levels in adolescents with anorexia nervosa of the restrictive type. Neuropsychobiology. 2015 Jun 1;71(3):154-157. https://doi.org/10.1159/000381399
Conti, Elisa ; Nacinovich, Renata ; Bomba, Monica ; Raggi, Maria E. ; Neri, Francesca ; Ferrarese, Carlo ; Tremolizzo, Lucio. / Beta-amyloid plasma levels in adolescents with anorexia nervosa of the restrictive type. In: Neuropsychobiology. 2015 ; Vol. 71, No. 3. pp. 154-157.
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