Beta-endorphin concentrations in the peripheral blood mononuclear cells of migraine and tension-type headache patients

Massimo Leone, Domenico D'amico, Gennaro Bussone, Paola Sacerdote, Alberto E. Panerai

Research output: Contribution to journalArticlepeer-review

Abstract

Levels of b-endorphin in peripheral blood mononuclear cells have been studied as a new approach to investigating opioid tone in migraine and tension-type headache. Sixty-one patients with migraine without aura, 39 with migraine with aura and 23 with episodic tension-type headache were compared with 37 healthy controls. Peripheral blood samples were taken from patients not enduring headache attacks and not undergoing prophylactic treatment. A significant reduction in peripheral blood mononuclear cell b-endorphin concentrations was observed in migraine patients with and without aura, but not in tension-type headache patients. Altered transmitter modulation to peripheral blood mononuclear cells may be the cause of this alteration, which could be part of a more diffuse opioid system derangement in migraine subjects.

Original languageEnglish
Pages (from-to)155-157
Number of pages3
JournalCephalalgia
Volume12
Issue number3
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Clinical Neurology

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