Abstract
Opioid system hypofunction has been postulated in cluster headache (CH) on the basis of reduced opioid levels found in the cerebrospinal fluid (CSF). In this study beta-endorphin levels were monitored in the peripheral blood mononuclear cells of 65 episodic CH patients (32 in remission and 33 in cluster period) and 50 healthy controls. Beta-endorphin levels were significantly lower than controls in CH patients experiencing both phases of the illness (ANOVA, p <0.0001). The persistence of this abnormality during pain-free remission suggests a primary alteration in the regulation of beta-endorphin in peripheral blood mononuclear cells. We speculate that these findings reflect reduced CNS levels of beta-endorphin in CH.
| Original language | English |
|---|---|
| Pages (from-to) | 413-416 |
| Number of pages | 4 |
| Journal | Cephalalgia |
| Volume | 13 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1993 |
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Keywords
- beta-endorphin
- cluster headache
- lymphocytes
- pain
ASJC Scopus subject areas
- Clinical Neurology
Cite this
Beta-endorphin levels are reduced in peripheral blood mononuclear cells of cluster headache patients. / Leone, M.; Sacerdote, P.; D'Amico, D.; Panerai, A. E.; Bussone, G.
In: Cephalalgia, Vol. 13, No. 6, 1993, p. 413-416.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Beta-endorphin levels are reduced in peripheral blood mononuclear cells of cluster headache patients
AU - Leone, M.
AU - Sacerdote, P.
AU - D'Amico, D.
AU - Panerai, A. E.
AU - Bussone, G.
PY - 1993
Y1 - 1993
N2 - Opioid system hypofunction has been postulated in cluster headache (CH) on the basis of reduced opioid levels found in the cerebrospinal fluid (CSF). In this study beta-endorphin levels were monitored in the peripheral blood mononuclear cells of 65 episodic CH patients (32 in remission and 33 in cluster period) and 50 healthy controls. Beta-endorphin levels were significantly lower than controls in CH patients experiencing both phases of the illness (ANOVA, p <0.0001). The persistence of this abnormality during pain-free remission suggests a primary alteration in the regulation of beta-endorphin in peripheral blood mononuclear cells. We speculate that these findings reflect reduced CNS levels of beta-endorphin in CH.
AB - Opioid system hypofunction has been postulated in cluster headache (CH) on the basis of reduced opioid levels found in the cerebrospinal fluid (CSF). In this study beta-endorphin levels were monitored in the peripheral blood mononuclear cells of 65 episodic CH patients (32 in remission and 33 in cluster period) and 50 healthy controls. Beta-endorphin levels were significantly lower than controls in CH patients experiencing both phases of the illness (ANOVA, p <0.0001). The persistence of this abnormality during pain-free remission suggests a primary alteration in the regulation of beta-endorphin in peripheral blood mononuclear cells. We speculate that these findings reflect reduced CNS levels of beta-endorphin in CH.
KW - beta-endorphin
KW - cluster headache
KW - lymphocytes
KW - pain
UR - http://www.scopus.com/inward/record.url?scp=0027717260&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027717260&partnerID=8YFLogxK
U2 - 10.1046/j.1468-2982.1993.1306413.x
DO - 10.1046/j.1468-2982.1993.1306413.x
M3 - Article
C2 - 8313456
AN - SCOPUS:0027717260
VL - 13
SP - 413
EP - 416
JO - Cephalalgia
JF - Cephalalgia
SN - 0333-1024
IS - 6
ER -