Beta-endorphin levels are reduced in peripheral blood mononuclear cells of cluster headache patients

M. Leone, P. Sacerdote, D. D'Amico, A. E. Panerai, G. Bussone

Research output: Contribution to journalArticlepeer-review

Abstract

Opioid system hypofunction has been postulated in cluster headache (CH) on the basis of reduced opioid levels found in the cerebrospinal fluid (CSF). In this study beta-endorphin levels were monitored in the peripheral blood mononuclear cells of 65 episodic CH patients (32 in remission and 33 in cluster period) and 50 healthy controls. Beta-endorphin levels were significantly lower than controls in CH patients experiencing both phases of the illness (ANOVA, p <0.0001). The persistence of this abnormality during pain-free remission suggests a primary alteration in the regulation of beta-endorphin in peripheral blood mononuclear cells. We speculate that these findings reflect reduced CNS levels of beta-endorphin in CH.

Original languageEnglish
Pages (from-to)413-416
Number of pages4
JournalCephalalgia
Volume13
Issue number6
DOIs
Publication statusPublished - 1993

Keywords

  • beta-endorphin
  • cluster headache
  • lymphocytes
  • pain

ASJC Scopus subject areas

  • Clinical Neurology

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