Beta-glucan- or rice bran-enriched foods: A comparative crossover clinical trial on lipidic pattern in mildly hypercholesterolemic men

M. Rondanelli, A. Opizzi, F. Monteferrario, C. Klersy, R. Cazzola, B. Cestaro

Research output: Contribution to journalArticle

Abstract

Background/ Objectives:There has been growing interest in using dietary intervention to improve the lipid profile. This work aims at analyzing the effects and the comparison of the enrichment of a diet with beta-glucans or rice bran in mildly hypercholesterolemic men.Subjects/Methods:The subjects initially consumed a 3-week Step 1 American Heart Association diet with rice bran-enriched foods. After this adaptation period, volunteers were randomly assigned to follow a crossover, controlled trial that consisted of two treatment with beta-glucan- or rice bran-enriched foods, each of 4 weeks, with a 3-week wash-out, like the adaptation period, between periods. Fasted blood samples were collected on days 0, 21, 49, 70 and 98 in both study arms for measuring low-density lipoprotein (LDL)-cholesterol (primary outcome), total cholesterol, high-density lipoprotein (HDL)-cholesterol, triglycerides, apolipoprotein (apo) A-I, apo B and glucose levels.Results:Twenty-four men (mean age: 50.35.3, mean body mass index: 24.91.9) completed the 14-week trial. Subjects in the 3-week adaptation period experienced significant reductions in the mean level of LDL cholesterol, total cholesterol, total cholesterol/HDL cholesterol, LDL cholesterol/HDL cholesterol, apo A-I, apo A-I/apo B and glucose. During the intervention diet periods, a difference was found between treatment groups for the mean change in LDL (0.21 (95% confidence interval (CI): 0.02-0.40), P0.033) and total cholesterol (0.34 (95% CI: 0.20-0.47), P0.001). Other parameters evaluated were not significantly affected by the diet consumed.Conclusions:The results of the present crossover clinical trial showed that beta-glucan-enriched foods are more effective in lowering serum LDL levels, compared with rice bran-enriched foods.

Original languageEnglish
Pages (from-to)864-871
Number of pages8
JournalEuropean Journal of Clinical Nutrition
Volume65
Issue number7
DOIs
Publication statusPublished - Jul 2011

Fingerprint

Fortified Food
beta-Glucans
Cross-Over Studies
Apolipoprotein A-I
Cholesterol
Clinical Trials
LDL Cholesterol
HDL Cholesterol
Diet
Apolipoproteins B
LDL Lipoproteins
Confidence Intervals
Glucose
Volunteers
Triglycerides
Body Mass Index
Lipids
Oryza
Therapeutics
Serum

Keywords

  • barley
  • beta-glucan
  • dietary fiber
  • rice bran
  • serum cholesterol

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Beta-glucan- or rice bran-enriched foods : A comparative crossover clinical trial on lipidic pattern in mildly hypercholesterolemic men. / Rondanelli, M.; Opizzi, A.; Monteferrario, F.; Klersy, C.; Cazzola, R.; Cestaro, B.

In: European Journal of Clinical Nutrition, Vol. 65, No. 7, 07.2011, p. 864-871.

Research output: Contribution to journalArticle

@article{8f6e175f365b471f99c65c26cb3fa565,
title = "Beta-glucan- or rice bran-enriched foods: A comparative crossover clinical trial on lipidic pattern in mildly hypercholesterolemic men",
abstract = "Background/ Objectives:There has been growing interest in using dietary intervention to improve the lipid profile. This work aims at analyzing the effects and the comparison of the enrichment of a diet with beta-glucans or rice bran in mildly hypercholesterolemic men.Subjects/Methods:The subjects initially consumed a 3-week Step 1 American Heart Association diet with rice bran-enriched foods. After this adaptation period, volunteers were randomly assigned to follow a crossover, controlled trial that consisted of two treatment with beta-glucan- or rice bran-enriched foods, each of 4 weeks, with a 3-week wash-out, like the adaptation period, between periods. Fasted blood samples were collected on days 0, 21, 49, 70 and 98 in both study arms for measuring low-density lipoprotein (LDL)-cholesterol (primary outcome), total cholesterol, high-density lipoprotein (HDL)-cholesterol, triglycerides, apolipoprotein (apo) A-I, apo B and glucose levels.Results:Twenty-four men (mean age: 50.35.3, mean body mass index: 24.91.9) completed the 14-week trial. Subjects in the 3-week adaptation period experienced significant reductions in the mean level of LDL cholesterol, total cholesterol, total cholesterol/HDL cholesterol, LDL cholesterol/HDL cholesterol, apo A-I, apo A-I/apo B and glucose. During the intervention diet periods, a difference was found between treatment groups for the mean change in LDL (0.21 (95{\%} confidence interval (CI): 0.02-0.40), P0.033) and total cholesterol (0.34 (95{\%} CI: 0.20-0.47), P0.001). Other parameters evaluated were not significantly affected by the diet consumed.Conclusions:The results of the present crossover clinical trial showed that beta-glucan-enriched foods are more effective in lowering serum LDL levels, compared with rice bran-enriched foods.",
keywords = "barley, beta-glucan, dietary fiber, rice bran, serum cholesterol",
author = "M. Rondanelli and A. Opizzi and F. Monteferrario and C. Klersy and R. Cazzola and B. Cestaro",
year = "2011",
month = "7",
doi = "10.1038/ejcn.2011.48",
language = "English",
volume = "65",
pages = "864--871",
journal = "European Journal of Clinical Nutrition",
issn = "0954-3007",
publisher = "Nature Publishing Group",
number = "7",

}

TY - JOUR

T1 - Beta-glucan- or rice bran-enriched foods

T2 - A comparative crossover clinical trial on lipidic pattern in mildly hypercholesterolemic men

AU - Rondanelli, M.

AU - Opizzi, A.

AU - Monteferrario, F.

AU - Klersy, C.

AU - Cazzola, R.

AU - Cestaro, B.

PY - 2011/7

Y1 - 2011/7

N2 - Background/ Objectives:There has been growing interest in using dietary intervention to improve the lipid profile. This work aims at analyzing the effects and the comparison of the enrichment of a diet with beta-glucans or rice bran in mildly hypercholesterolemic men.Subjects/Methods:The subjects initially consumed a 3-week Step 1 American Heart Association diet with rice bran-enriched foods. After this adaptation period, volunteers were randomly assigned to follow a crossover, controlled trial that consisted of two treatment with beta-glucan- or rice bran-enriched foods, each of 4 weeks, with a 3-week wash-out, like the adaptation period, between periods. Fasted blood samples were collected on days 0, 21, 49, 70 and 98 in both study arms for measuring low-density lipoprotein (LDL)-cholesterol (primary outcome), total cholesterol, high-density lipoprotein (HDL)-cholesterol, triglycerides, apolipoprotein (apo) A-I, apo B and glucose levels.Results:Twenty-four men (mean age: 50.35.3, mean body mass index: 24.91.9) completed the 14-week trial. Subjects in the 3-week adaptation period experienced significant reductions in the mean level of LDL cholesterol, total cholesterol, total cholesterol/HDL cholesterol, LDL cholesterol/HDL cholesterol, apo A-I, apo A-I/apo B and glucose. During the intervention diet periods, a difference was found between treatment groups for the mean change in LDL (0.21 (95% confidence interval (CI): 0.02-0.40), P0.033) and total cholesterol (0.34 (95% CI: 0.20-0.47), P0.001). Other parameters evaluated were not significantly affected by the diet consumed.Conclusions:The results of the present crossover clinical trial showed that beta-glucan-enriched foods are more effective in lowering serum LDL levels, compared with rice bran-enriched foods.

AB - Background/ Objectives:There has been growing interest in using dietary intervention to improve the lipid profile. This work aims at analyzing the effects and the comparison of the enrichment of a diet with beta-glucans or rice bran in mildly hypercholesterolemic men.Subjects/Methods:The subjects initially consumed a 3-week Step 1 American Heart Association diet with rice bran-enriched foods. After this adaptation period, volunteers were randomly assigned to follow a crossover, controlled trial that consisted of two treatment with beta-glucan- or rice bran-enriched foods, each of 4 weeks, with a 3-week wash-out, like the adaptation period, between periods. Fasted blood samples were collected on days 0, 21, 49, 70 and 98 in both study arms for measuring low-density lipoprotein (LDL)-cholesterol (primary outcome), total cholesterol, high-density lipoprotein (HDL)-cholesterol, triglycerides, apolipoprotein (apo) A-I, apo B and glucose levels.Results:Twenty-four men (mean age: 50.35.3, mean body mass index: 24.91.9) completed the 14-week trial. Subjects in the 3-week adaptation period experienced significant reductions in the mean level of LDL cholesterol, total cholesterol, total cholesterol/HDL cholesterol, LDL cholesterol/HDL cholesterol, apo A-I, apo A-I/apo B and glucose. During the intervention diet periods, a difference was found between treatment groups for the mean change in LDL (0.21 (95% confidence interval (CI): 0.02-0.40), P0.033) and total cholesterol (0.34 (95% CI: 0.20-0.47), P0.001). Other parameters evaluated were not significantly affected by the diet consumed.Conclusions:The results of the present crossover clinical trial showed that beta-glucan-enriched foods are more effective in lowering serum LDL levels, compared with rice bran-enriched foods.

KW - barley

KW - beta-glucan

KW - dietary fiber

KW - rice bran

KW - serum cholesterol

UR - http://www.scopus.com/inward/record.url?scp=79960083988&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960083988&partnerID=8YFLogxK

U2 - 10.1038/ejcn.2011.48

DO - 10.1038/ejcn.2011.48

M3 - Article

C2 - 21505506

VL - 65

SP - 864

EP - 871

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

SN - 0954-3007

IS - 7

ER -