Beta-glucan- or rice bran-enriched foods: A comparative crossover clinical trial on lipidic pattern in mildly hypercholesterolemic men

M. Rondanelli, A. Opizzi, F. Monteferrario, C. Klersy, R. Cazzola, B. Cestaro

Research output: Contribution to journalArticlepeer-review


Background/ Objectives:There has been growing interest in using dietary intervention to improve the lipid profile. This work aims at analyzing the effects and the comparison of the enrichment of a diet with beta-glucans or rice bran in mildly hypercholesterolemic men.Subjects/Methods:The subjects initially consumed a 3-week Step 1 American Heart Association diet with rice bran-enriched foods. After this adaptation period, volunteers were randomly assigned to follow a crossover, controlled trial that consisted of two treatment with beta-glucan- or rice bran-enriched foods, each of 4 weeks, with a 3-week wash-out, like the adaptation period, between periods. Fasted blood samples were collected on days 0, 21, 49, 70 and 98 in both study arms for measuring low-density lipoprotein (LDL)-cholesterol (primary outcome), total cholesterol, high-density lipoprotein (HDL)-cholesterol, triglycerides, apolipoprotein (apo) A-I, apo B and glucose levels.Results:Twenty-four men (mean age: 50.35.3, mean body mass index: 24.91.9) completed the 14-week trial. Subjects in the 3-week adaptation period experienced significant reductions in the mean level of LDL cholesterol, total cholesterol, total cholesterol/HDL cholesterol, LDL cholesterol/HDL cholesterol, apo A-I, apo A-I/apo B and glucose. During the intervention diet periods, a difference was found between treatment groups for the mean change in LDL (0.21 (95% confidence interval (CI): 0.02-0.40), P0.033) and total cholesterol (0.34 (95% CI: 0.20-0.47), P0.001). Other parameters evaluated were not significantly affected by the diet consumed.Conclusions:The results of the present crossover clinical trial showed that beta-glucan-enriched foods are more effective in lowering serum LDL levels, compared with rice bran-enriched foods.

Original languageEnglish
Pages (from-to)864-871
Number of pages8
JournalEuropean Journal of Clinical Nutrition
Issue number7
Publication statusPublished - Jul 2011


  • barley
  • beta-glucan
  • dietary fiber
  • rice bran
  • serum cholesterol

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


Dive into the research topics of 'Beta-glucan- or rice bran-enriched foods: A comparative crossover clinical trial on lipidic pattern in mildly hypercholesterolemic men'. Together they form a unique fingerprint.

Cite this