Beta-interferon, retinoids and tamoxifen combination in advanced breast cancer

F. Recchia, S. Rea, S. De Filippis, M. Rosselli, G. Corrao, A. Gulino, G. Sica

Research output: Contribution to journalArticlepeer-review


Purpose: To investigate, in patients with metastatic breast cancer (MBC), a combination of retinoids, beta-interferon (β-IFN) and tamoxifen (TAM). Patients and Methods: This trial was conducted from January 1987 to June 1992 in 85 consecutive patients with MBC. All patients had been treated for metastatic disease: 43 patients received chemotherapy, 35 received hormone therapy and 7 received both. Forty-nine patients, with a better prognosis, and a longer disease-free survival (DFS) were treated with β-IFN 1 x 106 IU/m2 subcutaneously three times a week, TAM 10 mg TID, retinyl palmitate (R) 50,000 IU BID. Thirty-six patients with shorter DFS, were first treated with 8 courses of chemotherapy followed, in responders, by β-IFN, R and TAM. Results: With a median follow-up of 7 years (minimum 4 years) 59% of 85 evaluable patients responded, 20% had stabilization of disease and 21% progressed. Median response duration was 43 months. Median survival was 28 months and 25% of patients were alive after 9 years. Toxicity of biological therapy was moderate. Conclusions: Our data show that β-IFN, TAM and R combination is effective as salvage therapy in patients with MBC.

Original languageEnglish
Pages (from-to)203-208
Number of pages6
JournalClinica Terapeutica
Issue number3
Publication statusPublished - May 1998


  • Chemotherapy
  • Interferon
  • Metastatic breast cancer
  • Retinoids
  • Tamoxifen

ASJC Scopus subject areas

  • Medicine(all)


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