Beta-oxidation of N-nitrosodiethanolamine in different animal species in vitro and in vivo.

M. Bonfanti, C. Magagnotti, R. Fanelli, L. Airoldi

Research output: Contribution to journalArticle

Abstract

The metabolism of N-nitrosodiethanolamine (NDELA) was studied to assess whether the formation of the beta-oxidized metabolites, N-nitroso(2-hydroxyethyl) (formylmethyl)amine (NHEFMA) and N-nitroso(2-hydroxyethyl)(carboxymethyl)amine (NHECMA), is involved in tumour induction in various animal species with different susceptibilities to NDELA carcinogenicity. In-vitro and in-vivo studies showed that all the animal species considered metabolize NDELA through the beta-oxidation pathway, suggesting that there is no correlation between carcinogenesis by NDELA and its beta-oxidation.

Original languageEnglish
Pages (from-to)91-93
Number of pages3
JournalIARC scientific publications
Issue number84
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Medicine(all)

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    Bonfanti, M., Magagnotti, C., Fanelli, R., & Airoldi, L. (1987). Beta-oxidation of N-nitrosodiethanolamine in different animal species in vitro and in vivo. IARC scientific publications, (84), 91-93.